document_title: Contact lens

question_text: when did the first contact lenses come out

question_tokens: when did the first contact lenses come out

text: Contact lens

text: History[edit]

text: Leonardo da Vinci is frequently credited with introducing the idea of contact lenses in his 1508 Codex of the eye, Manual D,[8] wherein he described a method of directly altering corneal power by either submerging the head in a bowl of water or wearing a water-filled glass hemisphere over the eye. Neither idea was practically implementable in da Vinci's time.[9]:9 He did not suggest his idea be used for correcting vision, as he was more interested in learning about the mechanisms of accommodation of the eye.[8]

text: Descartes proposed another idea in 1636—a glass tube filled with liquid placed in direct contact with the cornea. The protruding end was to be composed of clear glass, shaped to correct vision; however, the idea was impracticable since it rendered blinking impossible.

text: In 1801, Thomas Young made a pair of basic contact lenses based on Descartes' model. He used wax to affix water-filled lenses to his eyes, which neutralized its refractive power. He then corrected for it with another pair of lenses.[9]

text: However, like da Vinci's, Young's device was not intended to correct refraction errors. Sir John Herschel, in a footnote of the 1845 edition of the Encyclopedia Metropolitana, posed two ideas for the visual correction: the first "a spherical capsule of glass filled with animal jelly", and "a mould of the cornea" that could be impressed on "some sort of transparent medium".[10] Though Herschel reportedly never tested these ideas, they were both later advanced by several independent inventors such as Hungarian Dallos with István Komáromy (1929)[clarification needed], who perfected a method of making molds from living eyes. This enabled the manufacture of lenses that, for the first time, conformed to the actual shape of the eye.

text: In 1888, German ophthalmologist Adolf Gaston Eugen Fick constructed and fitted the first successful contact lens.[11] While working in Zürich, he described fabricating afocal scleral contact shells, which rested on the less sensitive rim of tissue around the cornea, and experimentally fitting them; initially on rabbits, then on himself, and lastly on a small group of volunteers. These lenses were made from heavy blown glass and were 18–21 mm (0.71–0.83 in) in diameter. Fick filled the empty space between cornea and glass with a dextrose solution. He published his work, "Contactbrille", in the journal Archiv für Augenheilkunde in March 1888.

text: Fick's lens was large and unwieldy, and could only be worn for a couple of hours at a time. August Müller in Kiel, Germany, corrected his own severe myopia with a more convenient blown-glass scleral contact lens of his own manufacture in 1888.[12]

text: Also in 1887, Louis J. Girard invented a similar scleral form of contact lens.[13] Blown-glass scleral lenses remained the only form of contact lens until the 1930s when Perspex/Plexiglas was developed, allowing plastic scleral lenses to be manufactured for the first time. In 1936, optometrist William Feinbloom introduced plastic in lenses, making them lighter and more convenient.[14] These lenses were a combination of glass and plastic. In 1940, German optometrist Heinrich Wöhlk produced fully plastic lenses, based on experiments performed during the 1930s.[citation needed]

text: In 1949, the first "corneal" lenses were developed.[15][16][17][18] These were much smaller than the original scleral lenses, as they sat only on the cornea rather than across all of the visible ocular surface, and could be worn up to sixteen hours a day. Polymethyl methacrylate (PMMA) corneal lenses became the first contact lenses to have mass appeal through the 1960s, as lens designs became more sophisticated with improving manufacturing technology.[citation needed]

text: Early corneal lenses of the 1950s and 60s were relatively expensive and fragile, resulting in the development of a market for contact lens insurance. Replacement Lens Insurance, Inc. (now known as RLI Corp.) phased out its original flagship product in 1994 after contact lenses became more affordable and easier to replace.[citation needed]

text: One major disadvantage of PMMA lenses is that they allow no oxygen to get through to the conjunctiva and cornea, causing a number of adverse and potentially serious clinical effects. By the end of the 1970s and through the 80s and 90s, a range of oxygen-permeable but rigid materials were developed to overcome this problem. Chemist Norman Gaylord played a prominent role in the development of these new oxygen-permeable contact lenses.[19] Collectively, these polymers are referred to as rigid gas permeable or RGP materials or lenses. Though all the above contact lens types—sclerals, PMMAs and RGPs—could be correctly referred to as "rigid" or "hard", the latter term is now used to the original PMMAs, which are still occasionally fitted and worn, whereas "rigid" is a generic term for all these lens types; thus hard lenses (PMMAs) are a subset of rigid contact lenses. Occasionally, the term "gas permeable" is used to describe RGPs, which is somewhat misleading as soft contact lenses are also gas permeable in that they allow oxygen to get through to the ocular surface.

text: The principal breakthrough in soft lenses was made by Czech chemists Otto Wichterle and Drahoslav Lím, who published their work "Hydrophilic gels for biological use" in the journal Nature in 1959.[20] In 1965, National Patent Development Corporation (NPDC) bought the American rights to produce the lenses and then sublicensed the rights to Bausch & Lomb, which started to manufacture them in the United States.[21] The Czech scientists' work led to the launch of the first soft (hydrogel) contact lenses in some countries in the 1960s and the first approval of the Soflens material by the US Food and Drug Administration (FDA) in 1971. These soft lenses were soon prescribed more often than rigid ones, due to the immediate and much greater comfort (rigid lenses require a period of adaptation before full comfort, if any, is achieved). Polymers from which soft lenses are manufactured improved over the next 25 years, primarily in terms of increasing oxygen permeability, by varying the ingredients. In 1972, British optometrist Rishi Agarwal was the first to suggest disposable soft contact lenses.[22][23]

text: In 1998, the first silicone hydrogel contact lenses were released by Ciba Vision in Mexico. These new materials encapsulated the benefits of silicone—which has extremely high oxygen permeability—with the comfort and clinical performance of the conventional hydrogels that had been used for the previous 30 years. These contact lenses were initially advocated primarily for extended (overnight) wear, although more recently, daily (no overnight) wear silicone hydrogels have been launched.

text: In a slightly modified molecule, a polar group is added without changing the structure of the silicone hydrogel. This is referred to as the Tanaka monomer because it was invented and patented by Kyoichi Tanaka of Menicon Co. of Japan in 1979. Second-generation silicone hydrogels, such as galyfilcon A (Acuvue Advance, Vistakon) and senofilcon A (Acuvue Oasys, Vistakon), use the Tanaka monomer. Vistakon improved the Tanaka monomer even further and added other molecules, which serve as an internal wetting agent.[24]

text: Comfilcon A (Biofinity, CooperVision) was the first third-generation polymer. Its patent claims that the material uses two siloxy macromers of different sizes that, when used in combination, produce very high oxygen permeability (for a given water content). Enfilcon A (Avaira, CooperVision) is another third-generation material that is naturally wettable; its water content is 46%.[24]

text: Types[edit]

text: Contact lenses are classified in many different ways: by their primary function, material, wear schedule (how long a lens can be worn), and replacement schedule (how long before a lens needs to be discarded).

text: Functions[edit]

text: Corrective contact lenses[edit]

text: Corrective contact lenses are designed to improve vision, most commonly by correcting refractive error. This is done by directly focusing light so it enters the eye with the proper power for clear vision.

text: A spherical contact lens bends light evenly in every direction (horizontally, vertically, etc.). They are typically used to correct myopia and hypermetropia. A toric contact lens has a different focusing power horizontally than vertically, and as a result can correct for astigmatism. Some spherical rigid lenses can also correct for astigmatism. Because a toric lens must have the proper orientation to correct for a person's astigmatism, such a lens must have additional design characteristics to prevent it from rotating away from the ideal alignment. This can be done by weighting the bottom of the lens or by using other physical characteristics to rotate the lens back into position. Some toric contact lenses have marks or etchings that can assist the eye doctor or the user in fitting the lens. The first disposable toric contact lenses were introduced in 2000 by Vistakon.

text: Correction of presbyopia (a need for a reading prescription different from the prescription needed for distance) presents an additional challenge in the fitting of contact lenses. Two main strategies exist: multifocal lenses and monovision.

text: Multifocal contact lenses (e.g. bifocals or progressives) are comparable to spectacles with bifocals or progressive lenses because they have multiple focal points. Multifocal contact lenses are typically designed for constant viewing through the center of the lens, but some designs do incorporate a shift in lens position to view through the reading power (similar to bifocal glasses).

text: Monovision[25] is the use of single-vision lenses (one focal point per lens) to focus an eye (typically the dominant one) for distance vision and the other for near work. The brain then learns to use this setup to see clearly at all distances. A technique called modified monovision uses multifocal lenses and also specializes one eye for distance and the other for near, thus gaining the benefits of both systems. Alternatively, a person may simply wear reading glasses over their distance contact lenses. Care is advised for persons with a previous history of strabismus and those with significant phorias, who are at risk of eye misalignment under monovision.[26] Studies have shown no adverse effect to driving performance in adapted monovision contact lens wearers.[27]

text: Other types of vision correction[edit]

text: For those with certain color deficiencies, a red-tinted "X-Chrom" contact lens may be used. Although such a lens does not restore normal color vision, it allows some color-blind people to distinguish colors better.[28][29] Red-filtering contact lenses can also be an option for extreme light sensitivity in some visual deficiencies such as achromatopsia.[30]

text: ChromaGen contact lenses have been used and shown to have some limitations with vision at night although otherwise producing significant improvements in color vision.[31] An earlier study showed very significant improvements in color vision and patient satisfaction.[32]

text: Later work that used these ChromaGen lenses with dyslexics in a randomised, double-blind, placebo controlled trial showed highly significant[clarification needed] improvements in reading ability over reading without the lenses.[33] This system has been granted FDA approval for use in the United States.[citation needed]

text: Magnification is another area being researched for future contact lens applications.[34] Embedding of telescopic lenses and electronic components suggests that future uses of contact lenses may become extremely diverse. However, there are still barriers that prevent transition of these technologies, from research and development to practical application and commercial availability.

text: Cosmetic contact lenses[edit]

text: A cosmetic contact lens is designed to change the appearance of the eye. These lenses may also correct refractive error. Although many brands of contact lenses are lightly tinted to make them easier to handle, cosmetic lenses worn to change eye color are far less common, accounting for only 3% of contact lens fits in 2004.[35]

text: In the United States, the FDA labels non-corrective cosmetic contact lenses as decorative contact lenses. Like any contact lens, cosmetic lenses carry risks of mild to serious complications, including ocular redness, irritation and infection.[36]

text: Due to their medical nature, colored contact lenses, similar to regular ones, are illegal to purchase in the United States without a valid prescription. Those with perfect vision can buy color contacts for cosmetic reasons, but they still need their eyes to be measured for a "plano" prescription, meaning one with zero vision correction. This is for safety reasons so the lenses will fit the eye without causing irritation or redness.[37]

text: Some colored contact lenses completely cover the iris, thus dramatically changing eye colour. Other colored contact lenses merely tint the iris, highlighting and beautifying its natural colour.[38] A new trend in Japan, South Korea and China is the circle contact lens, which extend the appearance of the iris onto the sclera by having a dark tinted area all around. The result is an appearance of a bigger, wider iris, a look reminiscent of dolls' eyes.[39]

text: One of the drawbacks of cosmetic lenses is not knowing how they will look before physically trying them on. This has led to an industry where lens retailers are heavily influenced by cutting edge digital fashion technology, specifically the Virtual Dressing Room technology. Virtual Dressing Room technology offers users the option to upload a photo so they can virtually try on different lenses and experience how they will look before committing to a purchase. Examples of retailers that currently offer this technology are Freshlook Color Studios and Colorful Eyes.[40][41]

text: Cosmetic lenses can have more direct medical applications. For example, some contact lenses can restore the appearance and, to some extent the function, of a damaged or missing iris.

text: Therapeutic scleral lenses[edit]

text: A scleral lens is a large, firm, oxygen permeable contact lens that rests on the sclera and creates a tear-filled vault over the cornea. The cause of this unique positioning is usually relevant to a specific patient whose cornea is too sensitive to support the lens directly. Scleral lenses may be used to improve vision and reduce pain and light sensitivity for people suffering from a growing number of disorders or injuries to the eye, such as severe dry eye syndrome (Kerotanconjuctivis sicca), microphthalmia, keratoconus, corneal ectasia, Stevens–Johnson syndrome, Sjögren's syndrome, aniridia, neurotrophic keratitis (aneasthetic corneas), complications post-LASIK, high order Aberrations of the eye, complications post-corneal transplant and pellucid degeneration. Injuries to the eye such as surgical complications, distorted corneal implants, as well as chemical and burn injuries also may be treated with scleral lenses. [42]

text: Therapeutic soft lenses[edit]

text: Soft lenses are often used in the treatment and management of non-refractive disorders of the eye. A bandage contact lens protects an injured or diseased cornea from the constant rubbing of blinking eyelids thereby allowing it to heal.[43] They are used in the treatment of conditions including bullous keratopathy, dry eyes, corneal abrasions and erosion, keratitis, corneal edema, descemetocele, corneal ectasis, Mooren's ulcer, anterior corneal dystrophy, and neurotrophic keratoconjunctivitis.[44] Contact lenses that deliver drugs to the eye have also been developed.[45]

text: Materials[edit]

text: Rigid lenses[edit]

text: Glass lenses were never comfortable enough to gain widespread popularity. The first lenses to do so were those made from polymethyl methacrylate (PMMA or Perspex/Plexiglas), now commonly referred to as "hard" lenses. Their main disadvantage is they do not allow oxygen to pass through to the cornea, which can cause a number of adverse and often serious clinical events. Starting in the late 1970s, improved rigid materials which were oxygen-permeable were developed. Contact lenses made from these materials are called rigid gas permeable lenses or 'RGPs'.

text: A rigid lens is able to replace the natural shape of the contact (cornea) with a new refracting surface. This means that a spherical rigid contact lens can correct astigmatism. Rigids can also be made as a front-toric, back-toric, or bitoric. This is different from a spherical contact lens in that one or both surfaces of the lens deliver a toric correction. Rigids can also correct for corneal irregularities, such as keratoconus. In most cases, patients with keratoconus see better through rigids than through glasses. Rigids are more chemically inert, allowing them to be worn in more challenging environments than soft lenses.[citation needed]

text: Soft lenses[edit]

text: While rigid lenses have been around for about 120 years, soft lenses are a much more recent development. The principal breakthrough in soft contact lenses made by Otto Wichterle led to the launch of the first soft (hydrogel) lenses in some countries in the 1960s and the approval of the "Soflens" daily material (polymacon) by the FDA in the US in 1971. Softs are usually comfortable right after insertion, while rigids require a period of adaptation before some comfort, if any, is achieved.

text: In 1998, silicone hydrogels became available. These materials have both the extremely high oxygen permeability of silicone and the comfort and clinical performance of the conventional hydrogels. Because silicone allows more oxygen permeability than water, oxygen permeability of silicone hydrogels is not tied to the lenses' water content. Lenses have now been developed with so much oxygen permeability that they are approved for overnight wear (extended wear). Lenses approved for daily wear are also available in silicone hydrogel materials.[46]

text: Disadvantages of silicone hydrogels are that they are slightly stiffer and the lens surface can be hydrophobic, thus less "wettable" – factors that influence comfort of lens use. New manufacturing techniques and changes to multipurpose solutions have minimized these effects. A surface modification process called plasma coating alters the lens surface's hydrophobic nature. Another technique incorporates internal rewetting agents to make the lens surface hydrophilic. A third process uses longer backbone polymer chains that results in less cross linking and increased wetting without surface alterations or additive agents.

text: Hybrid[edit]

text: A small number of hybrid lenses exist. Typically these contact lenses consist of a rigid center and a soft "skirt". A similar technique is the "piggybacking" of a smaller, rigid lens on the surface of a larger, soft lens. These techniques are often chosen to give the vision correction benefits of a rigid lens and the comfort of a soft lens. As of 2014[update], this is a new technology that only a few companies provide.[47]

text: Wear schedule[edit]

text: A "daily wear" (DW) contact lens is designed to be worn for one day and removed prior to sleeping. An "extended wear" (EW) contact lens is designed for continuous overnight wear, typically for up to 6 consecutive nights. Newer materials, such as silicone hydrogels, allow for even longer wear periods of up to 30 consecutive nights; these longer-wear lenses are often referred to as "continuous wear" (CW). EW and CW contact lenses can be worn overnight because of their high oxygen permeability. While awake, the eyes are mostly open, allowing oxygen from the air to dissolve into the tears and pass through the lens to the cornea. While asleep, oxygen is supplied from the blood vessels in the back of the eyelid. A lens hindering passage of oxygen to the cornea causes corneal hypoxia which can result in serious complications, such as corneal ulcer that, if left untreated, can permanently decrease vision. EW and CW contact lenses typically allow for a transfer of 5–6 times more oxygen than conventional softs, allowing the cornea to remain healthy, even with closed eyelids.

text: Wearing lenses designed for daily wear overnight has an increased risk for corneal infections, corneal ulcers and corneal neovascularization—this latter condition, once it sets in, cannot be reversed and will eventually spoil vision acuity through diminishing corneal transparency. The most common complication of extended wear is giant papillary conjunctivitis (GPC), sometimes associated with a poorly fitting contact lens.

text: Replacement schedule[edit]

text: Contact lenses are often categorized by their replacement schedule. Single use lenses (called 1-day or daily disposables) are discarded after one use. Because they do not have to stand up to the wear and tear of repeated uses, these lenses can be made thinner and lighter, greatly improving their comfort. Lenses replaced frequently gather fewer deposits of allergens and germs, making these lenses preferable for patients with ocular allergies or for those who are prone to infection. Single-use lenses are also useful for people who wear contact lenses infrequently, or when losing a lens is likely or not easily replaced (such as when on vacation). They are also considered useful for children because cleaning or disinfecting is not needed, leading to improved compliance.

text: Other disposable contact lenses are designed for replacement every two or four weeks. Quarterly or annual lenses, which used to be very common, are much less so. Rigid gas permeable lenses are very durable and may last for several years without the need for replacement. PMMA hards were very durable and were commonly worn for 5 to 10 years, but had several drawbacks.

text: Lenses with different replacement schedules can be made of the same material. Although the materials are alike, differences in the manufacturing processes determine if the resulting lens will be a "daily disposable" or one recommended for two or four week replacement. However, sometimes manufacturers use absolutely identical lenses and just repackage them with different labels.[48][49]

text: In the US, contact lens manufacturers must prove to the FDA that a lens is safe before it can be sold to the public. Typically, the prescribing doctor instructs patients to follow the same limitations used during those studies. This included wear time and replacement schedule.

text: Manufacturing[edit]

text: Typically, soft contact lenses are mass-produced, while rigids are custom-made to exact specifications for the individual patient.

text:
Spin-cast lenses – A soft lens manufactured by whirling liquid silicone in a revolving mold at high speed.[50]
Diamond turning – This type is cut and polished on a CNC lathe.[50] The lens starts out as a cylindrical disk held in the jaws of the lathe that is equipped with an industrial-grade diamond as the cutting tool. The CNC lathe may turn at nearly 6000 RPM as the cutter removes the desired amount of material from the inside of the lens. The concave (inner) surface of the lens is then polished with some fine abrasive paste, oil, and a small polyester cotton ball turned at high speeds. To hold the delicate lens in reverse manner, wax is used as an adhesive. The lens' convex (outer) surface is thus cut and polished by the same process. This method can be used to shape rigid as well as soft lenses. In the case of softs, the lens is cut from a dehydrated polymer that is rigid until water is reintroduced.
Molded – Molding is used to manufacture some brands of soft contact lenses. Rotating molds are used and the molten material is added and shaped by centripetal forces. Injection molding and computer control are also used to create nearly perfect lenses.[51] The lens is kept moist throughout the entire molding process and is never dried and rehydrated.

text: Many companies make contact lenses. In the United States, there are five major manufacturers:[52]

text:
Valeant Pharmaceuticals: through its Bausch & Lomb subsidiary.
Novartis: through its Alcon subsidiary.
The Cooper Companies: through its CooperVision subsidiary.
Johnson & Johnson; maker of Acuvue lenses.
X-Cel Specialty Contacts; maker of Westcon lenses.

text: Prescriptions[edit]

text: The parameters specified in a contact lens prescription may include:

text:
Material / Brand name
Base curve radius (BC, BCR)
Diameter (D, OAD)
Power in diopters
Center thickness (CT)

text: Prescriptions for contact lenses and glasses may be similar, but are not interchangeable. Prescribing of contact lenses is usually restricted to various combinations of ophthalmologists, optometrists and opticians. An eye examination is needed to determine an individual's suitability for contact lens wear. This typically includes a refraction to determine the proper power of the lens and an assessment of the health of the eye's anterior segment. Many eye diseases prohibits contact lens wear, such as active infections, allergies, and dry eye.[53] Keratometry is especially important in the fitting of rigid lenses.

text: United States[edit]

text: Contact lenses are prescribed by ophthalmologists, optometrists, or specially licensed opticians under the supervision of an eye doctor. Contact lenses can typically be ordered at the office that conducts the eye exam and fitting. The Fairness to Contact Lens Consumers Act[54] gives consumers the right to obtain a copy of their contact lens prescription, allowing them to fill it at the lens provider of their choice.

text: Complications[edit]

text: Contact lenses are generally safe as long as they are used correctly. Complications from contact lens wear affect roughly 5% of wearers yearly.[55] Improper use of a contact lens may affect the eyelid, the conjunctiva, and, most of all, the whole structure of the cornea.[55] Poor lens care can lead to infections by various microorganisms including bacteria, fungi, and Acanthamoeba (Acanthamoeba keratitis).

text: Many complications arise when contact lenses are worn not as prescribed (improper wear schedule or lens replacement). Sleeping in lenses not designed or approved for extended wear is a common cause of complications. Many people go too long before replacing their contacts, wearing lenses designed for 1, 14, or 30 days of wear for multiple months or years. While this does save on the cost of lenses, it risks permanent damage to the eye and even loss of sight.

text: One of the major factors that causes complications is that the contact lens is an oxygen barrier. The cornea needs a constant supply of oxygen to remain completely transparent and function as it should; it normally gets that oxygen from the surrounding air while awake, and from the blood vessels in the back of the eyelid while asleep. The most prominent risks associated with long-term, chronic low oxygen to the cornea include corneal neovascularization, increased epithelial permeability, bacterial adherence, microcysts, corneal edema, endothelial polymegethism, dry eye and potential increase in myopia.[56] That is why much of the research into the latest soft and rigid contact lens materials has centered on improving oxygen transmission through the lens.

text: Mishandling of contact lenses can also cause problems. Corneal abrasions can increase the chances of infection.[57] When combined with improper cleaning and disinfection of the lens, a risk of infection further increases. Decreased corneal sensitivity following extended contact lens wear may cause a patient to miss some of the earliest symptoms of such complications.[58]

text: The way contact lenses interact with the natural tear layer is a major factor in determining lens comfort and visual clarity. People suffering from dry eyes are particularly vulnerable to discomfort and episodes of brief blurry vision. Proper lens selection can minimize these effects.

text: Long-term wear (over five years) of contact lenses may "decrease the entire corneal thickness and increase the corneal curvature and surface irregularity."[59] Long-term wear of rigid contacts is associated with decreased corneal keratocyte density[60] and increased number of epithelial Langerhans cells.[61]

text: All contact lenses sold in the United States are studied and approved as safe by the FDA when specific handling and care procedures, wear schedules, and replacement schedules are followed.

text: Usage[edit]

text: Before touching the contact lens or the eye, it is important to wash hands thoroughly with soap and rinse well. Soaps containing moisturizers or allergens should be avoided as these can cause eye irritation.[62] Drying of hands using towels or tissues prior to handling contact lenses can transfer lint (fluff) to the hands and, subsequently, to the lenses, causing irritation upon insertion. Towels, unless freshly laundered on high temperature wash, are frequently contaminated with large quantities of bacteria and, as such, should be avoided when handling lenses. Dust, lint and other debris may collect on the outside of contact lenses. Again, hand contact with this material, prior to handling contact lenses, may transfer it to the lenses themselves. Rinsing the case under a source of clean running water, prior to opening it, can help alleviate this problem. Next the lens should be removed from its case and inspected for defects (e.g. splits, folds, lint). A 'gritty' or rough appearance to the lens surface may indicate that a considerable quantity of proteins, lipids and debris has built up on it and that additional cleaning is required; this is often accompanied and felt by unusually high irritation upon insertion.

text: Make sure the soft lens is not inserted inside-out. Edge of a lens turned inside out has a different appearance, especially when the lens is slightly folded. Insertion of an inside-out lens for a brief time (less than one minute) should not cause any damage to the eye. Some brands of lenses have markings (e.g. numbers) on the rim that make it easier to tell the front of the lens from the back.

text: The technique for removing or inserting a contact lens varies depending upon whether the lens is soft or rigid. There are many subtle variations to insertion and removal techniques. Because of differences in anatomy, manual dexterity, and visual limitations, every person must find the technique that works best for them. In all cases, the insertion and removal of lenses requires some training and practice on part of the user.

text: Insertion[edit]

text: Contact lenses are typically inserted into the eye by placing them on the pad of the index or middle finger with the concave side upward and then using that finger to place the lens on the eye. Rigid lenses should be placed directly on the cornea. Soft lenses may be placed on the sclera (white of the eye) and then slid into place. Another finger of the same hand, or a finger of the other hand, is used to keep the eye wide open. Alternatively, the user may close their eyes and then look towards their nose, sliding the lens into place over the cornea. Problems may arise if the lens folds, turns inside-out, slides off the finger prematurely, or adheres more tightly to the finger than the eye surface. A drop of solution may help the lens adhere to the eye.

text: When the lens first contacts the eye, it should be comfortable. A brief period of irritation may occur, caused by a difference in pH and/or salinity between that of the lens solution and the tear.[63][64] This discomfort fades quickly as the solution drains away and is replaced by the natural tears. However, if irritation persists, the cause could be a dirty, damaged, or inside-out lens. Removing and inspecting it for damage and proper orientation, and re-cleaning if necessary, should correct the problem. If discomfort continues, the lens should not be worn. In some cases, taking a break from lens wear for a day may correct the problem. In case of severe discomfort, or if it does not resolve by the next day, the person should be seen as soon as possible by an eye doctor to rule out potentially serious complications.

text: Removal[edit]

text: Removing contact lenses incorrectly could result in damage to the lens and injury to the eye so certain precautions must be taken. Rigid contact lenses can best be removed by pulling the eyelid tight and then blinking, whereupon the lens drops out. With one finger on the outer corner of the eyelids, or lateral canthus, the person stretches the eyelids towards the ear; the increased tension of the eyelid margins against the edge of lens allows the blink to break the capillary action that adheres the lens to the eye. The other hand is typically cupped underneath the eye to catch the lens as it drops out. For soft lenses, which have a stronger adherence to the eye surface, this technique is less suitable.

text: A soft contact lens may be removed by pinching the edge between the thumb and index finger. Moving the lens off the cornea first can improve comfort during removal and reduce risk of scratching the cornea with a fingernail. It is also possible to push or pull a soft lens far enough to the side or bottom of the eyeball to get it to fold then fall out, without pinching and thereby damaging it. If these techniques are used with a rigid lens, it may scratch the cornea.

text: There are also small tools specifically for removing lenses. Usually made of flexible plastic, they resemble small tweezers, or plungers that suction onto the front of the lens. Typically these tools are only used with rigid lenses. Extreme care must be exercised when using mechanical tools or fingernails to insert or remove contact lenses.

text: Care[edit]

text: Lens care varies depending on material and wear schedule. Daily disposables are discarded after a single use and thus require no cleaning. Other lenses need regular cleaning and disinfecting to prevent surface coating and infections.

text: There are many ways to clean and care for contact lenses, typically called care systems or lens solutions:

text: Multipurpose solutions

text: Hydrogen peroxide systems

text:
Enzymatic cleaner – Used for cleaning protein deposits off lenses, usually weekly, if the daily cleaner is not sufficient. Typically, this cleaner is in tablet form.
Ultraviolet, vibration, or ultrasonic devices – Used to both disinfect and clean CLs. The lenses are inserted inside the portable device (running on batteries and/or plug-in) for 2 to 6 minutes during which both the microorganisms and protein build-up are thoroughly cleaned. These devices are not usually available in optic retailers but are in other stores.[75][76][77]
Saline solution

text: Daily cleaner

text: Aside from cleaning the contact lenses, it is highly advised to also clean the cases to avoid any possible infection. Replacing the case monthly, and storing it in a clean and safe environment is also recommended.[78]

text: Contact lenses can be mechanically cleaned of more substantial protein, lipid and debris build up by rubbing them between the clean pad of a finger and the palm of a hand, using a small amount of cleaning fluid as a lubricant. However, this method does not sterilize the lenses and so should only be performed prior to a full sterilization cycle (e.g. when putting the contact lens away at night).

text: Some products must only be used with certain types of contact lenses. Water alone will not at all disinfect the lens, and can lead to lens contamination causing potentially irreparable harm to the eye.

text: Contact lens solutions often contain preservatives such as benzalkonium chloride and benzyl alcohol. Preservative-free products usually have shorter shelf lives, but are better suited for individuals with an allergy or sensitivity to a preservative. In the past, thiomersal was used as a preservative. In 1989, thiomersal was responsible for about 10% of problems related to contact lenses.[79] As a result, most products no longer contain thiomersal.

text: Current research[edit]

text: A large segment of current contact lens research is directed towards the treatment and prevention of conditions resulting from contact lens contamination and colonization by foreign organisms. Clinicians tend to agree that the most significant complication of contact lens wear is microbial keratitis and that the most predominant microbial pathogen is Pseudomonas aeruginosa.[80] Other organisms are also major causative factors in bacterial keratitis associated with contact lens wear, although their prevalence varies across different locations. These include both the Staphylococcus species (aureus and epidermidis) and the Streptococcus species, among others.[81][82] Microbial keratitis is a serious focal point of current research due to its potentially devastating effect on the eye, including severe vision loss.[83]

text: One specific research topic of interest is how microbes such as Pseudomonas aeruginosa invade the eye and cause infection. Although the pathogenesis of microbial keratitis is not well understood, many different factors have been investigated. One group of researchers showed that corneal hypoxia exacerbated Pseudomonas binding to the corneal epithelium, internalization of the microbes, and induction of the inflammatory response.[84] One way to alleviate hypoxia is to increase the amount of oxygen transmitted to the cornea. Although silicone-hydrogel lenses almost eliminate hypoxia in patients due to their very high levels of oxygen transmissibility,[85] they also seem to provide a more efficient platform for bacterial contamination and corneal infiltration than other conventional hydrogel soft CLs. A recent study showed that Pseudomonas aeruginosa and Staphylococcus epidermis adhere much more strongly to unworn silicone hydrogel CLs than conventional hydrogel lenses and that adhesion of Pseudomonas aeruginosa was 20 times stronger than that of Staphylococcus epidermidis.[86] This might partly explain why Pseudomonas infections are the most predominant. However, another study conducted with worn and unworn silicone and conventional hydrogel CLs showed that worn silicone CLs were less prone to Staphylococcus epidermidis colonization than conventional hydrogel lenses.[87]

text: Another important area of contact lens research deals with patient compliance. Compliance is a major issue[88] pertaining to the use of contact lenses because patient noncompliance often leads to contamination of the lens, storage case, or both.[89][90][91] However, careful users can extend the wear of lenses through proper handling: there is, unfortunately, no disinterested research on the issue of "compliance" or the length of time a user can safely wear a lens beyond its stated use. The introduction of multipurpose solutions and daily disposable lenses have helped to alleviate some of the problems observed from inadequate cleaning but new methods of combating microbial contamination are currently being developed. A silver-impregnated lens case has been developed which helps to eradicate any potentially contaminating microbes that come in contact with the lens case.[92] Additionally, a number of antimicrobial agents are being developed that have been embedded into contact lenses themselves. Lenses with covalently attached selenium molecules have been shown to reduce bacterial colonization without adversely affecting the cornea of a rabbit eye[93] and octylglucoside used as a lens surfactant significantly decreases bacterial adhesion.[94] These compounds are of particular interest to contact lens manufacturers and prescribing optometrists because they do not require any patient compliance to effectively attenuate the effects of bacterial colonization.

text: A recent area of research is in the field of bionic lenses. These are visual displays that include built-in electric circuits and light-emitting diodes and can harvest radio waves for their electric power. Bionic lenses can display information beamed from a mobile device overcoming the small display size problem. The technology involves embedding nano and microscale electronic devices in lenses. These lenses will also need to have an array of microlenses to focus the image so that it appears suspended in front of the wearer’s eyes. The lens could also serve as a head-up display for pilots or gamers.[95]

text: Drug administration through contact lenses is also becoming an area of research. One application is a lens that releases anesthesia to the eye for post-surgery pain relief, especially after PRK (photorefractive keratectomy) in which the healing process takes several days. One experiment shows that silicone contact lenses that contain vitamin E deliver pain medication for up to seven days compared with less than two hours in usual lenses.[95]

text: In popular culture[edit]

text: Films[edit]

text: One of the earliest known motion pictures to introduce the use of contact lenses as a make-up artist's device for enhancing the eyes was by the innovative actor Lon Chaney in the 1926 film The Road to Mandalay to create the effect of a character who had a blind eye.[96] Dr. Rueben Greenspoon applied them to Orson Welles for the film Citizen Kane in 1940. In the 1950s, contact lenses were starting to be used in British color horror films. An early example of this is the British actor Christopher Lee as the Dracula character in the 1958 color horror film Dracula, which helped to emphasize his horrific looking black pupils and red bloodshot eyes. Tony Curtis wore them in the 1968 film The Boston Strangler. Contact lenses were also used to better emphasize the sinister gaze of the demonic characters in 1968's Rosemary's Baby and 1973's The Exorcist. Colored custom-made contact lenses are now standard makeup for a number of special effects-based movies.[97][98]


document_title: And Can It Be

question_text: who wrote and can it be that i should gain

root

text: And Can It Be

text:
And Can It Be

Charles Wesley

Genre
Hymn

Written
1738

Text
Charles Wesley

Based on
Psalm 145

Meter
8.8.8.8 (L.M.)

Melody
"Sagina" by Thomas Campbell

tag: table

text: "And Can It Be That I Should Gain?" is a Christian hymn written by Charles Wesley. Diarmaid MacCulloch suggests that the hymn is one of the best-loved of Wesley's six thousand hymns.[1] It is also the source for the 2003 song "You Are My King (Amazing Love)" which reached No. 1 on the Billboard Christian songs chart.

tag: p

text: "And Can It Be" was written in 1738 to celebrate Wesley's conversion, which he regarded as having taken place on 21 May of that year.[2] The lines "My chains fell off, my heart was free/I rose, went forth, and followed thee" are based on the story of the Liberation of Saint Peter in the New Testament.[3]

text:
Wikisource has original text related to this article:
And Can It Be


document_title: Death of a Clown

question_text: who sang let's all drink to the death of a clown

question_tokens: who sang let 's all drink to the death of a clown

text: Death of a Clown

text:
"Death of a Clown"

Single by Dave Davies

from the album Something Else by The Kinks

B-side
"Love Me Till the Sun Shines"

Released
7 July 1967

Format
7", 45 rpm

Recorded
June 1967

Genre
Rock, pop, folk rock

Label
Pye 7N 17356

Songwriter(s)
Dave Davies, Ray Davies

Producer(s)
Shel Talmy

Dave Davies singles chronology

"Death of a Clown"
(1967)
"Susannah's Still Alive"
(1967)

"Death of a Clown"
(1967)
"Susannah's Still Alive"
(1967)

text: "Death of a Clown" is a song by Dave Davies, member of British rock group The Kinks, released as his debut solo single in 1967. The song was co-written with his brother Ray Davies, who contributed the 5-bar "La la la" hook; Ray's first wife, Rasa, sings this phrase as well as descant in the second verse, while Ray himself sings harmony in the refrain. Nicky Hopkins played the distinctive introduction, using fingerpicks on the strings of a piano. The single was credited to Dave Davies but the song also appeared on the Kinks' album Something Else by The Kinks, released later in 1967.

text: Background[edit]

text: In an interview with Yahoo!, Dave Davies said that "Death of a Clown" was written about the repetitive performing schedule he and the rest of the Kinks worked through. He said, "One night I nodded off at a party and woke up and saw all these decadent people running around. I had a vision of being a circus clown. I thought, “What are we doing?” We were going from day to day to day like performing seals. And that’s where I got the idea for 'Death of a Clown.' I went back to me mum’s house with the same old out-of-tune piano and I plunked out three notes, and it turned into the song."[1]

text: The single release was met with considerable success in the UK, hitting #3,[2] thus prompting Dave Davies to consider embarking on a solo career. When subsequent singles were met with less success, the idea was set aside until 1980, with his debut album being AFL1-3603.


document_title: Hannibal Lecter (franchise)

question_text: which is first silence of the lambs and hannibal

text: Hannibal Lecter (franchise)

text: Novels[edit]

text:
Red Dragon (1981)
The Silence of the Lambs (1988)
Hannibal (1999)
Hannibal Rising (2006)

tag: ul

text: Films and television[edit]

text:
Manhunter (1986)
The Silence of the Lambs (1991)
Hannibal (2001)
Red Dragon (2002)
Hannibal Rising (2007)
Hannibal (TV series) (2013–15)

text: The first adaptation was the 1986 film Manhunter, which was an adaptation of Red Dragon, directed by Michael Mann.

text: The next adaptation was 1991's The Silence of the Lambs, which was directed by Jonathan Demme and was the first film to feature Anthony Hopkins in the role of Hannibal Lecter. Silence was a success, both critically and financially, and went on to become the third film in Academy Awards history to win in all top five categories (Best Actor for Hopkins, Best Actress for Jodie Foster, Best Director for Demme, Best Adapted Screenplay for Ted Tally, and Best Picture). Hopkins reprised the role in the next two films, 2001's Hannibal, a sequel directed by Ridley Scott, and 2002's Red Dragon, a prequel directed by Brett Ratner. In 2002, Hopkins revealed that he had written a screenplay for another sequel, ending with Clarice killing Lecter but it was not produced.[1]

text: In 2007, Hannibal Rising was released. The film is a prequel, directed by Peter Webber and starring Gaspard Ulliel as Lecter.

text: In 2013, the TV series Hannibal premiered. Developed by Bryan Fuller, it is not a direct adaptation, but based on characters and elements from the novels. Some male characters have become female, such as Freddy Lounds, who is renamed Fredricka "Freddie" Lounds. The series has garnered much critical acclaim since its premiere, winning the 2014 and 2015 Saturn Award for Best Network Television Series, as well as the inaugural Best Action-Thriller Television Series in 2016.

text: In 2016, when asked if there were any sequels that he wished he could revisit, Hopkins said, "I made the mistake of doing two more [Hannibal Lecter movies] and I should have only done one."[2]

text: In 2017, Foster reprised her role as Starling in a skit titled "Clarice Probes Hannibal Lecter About Trump's Russia Ties" on The Late Show with Stephen Colbert, opposite Stephen Colbert as Hannibal Lecter. In the skit, Clarice questions Lecter on his relationship with Donald Trump and what he can tell her about his relationship with Russia.[3]

text: Cast and characters[edit]

text:
Manhunter(1986)

The Silence of the Lambs(1991)

Hannibal(2001)

Red Dragon(2002)

Hannibal Rising(2007)

Hannibal(TV series)(2013–15)

Hannibal Lecter

Brian Cox  (as Hannibal Lecktor)

Anthony Hopkins

Gaspard Ulliel  Aaran Thomas (young)

Mads Mikkelsen

Will Graham

William Petersen

Edward Norton

Hugh Dancy

Jack Crawford

Dennis Farina

Scott Glenn

Harvey Keitel

Laurence Fishburne

Frederick Chilton

Benjamin Hendrickson

Anthony Heald

Anthony Heald

Raúl Esparza

Francis Dolarhyde(The Tooth Fairy)

Tom Noonan  (as Francis Dollarhyde)

Ralph Fiennes  Alex D. Linz (young)

Richard Armitage

Clarice Starling

Jodie Foster  Masha Skorobogatov (young)

Julianne Moore

Buffalo Bill(Jame Gumb)

Ted Levine

Barney Matthews

Frankie Faison

Jonathan Tucker  (as Matthew Brown)

Freddy Lounds

Stephen Lang

Philip Seymour Hoffman

Lara Jean Chorostecki  (as Fredricka "Freddie" Lounds)

Mason Verger

Gary Oldman

Michael PittJoe Anderson

Paul Krendler

Ron Vawter

Ray Liotta

Cynthia Nixon(as Kade Prurnell)[4]

Reba McClane

Joan Allen

Emily Watson

Rutina Wesley

Molly Graham

Kim Greist

Mary-Louise Parker

Nina Arianda

Rinaldo Pazzi

Giancarlo Giannini

Fortunato Cerlino

Cordell Doemling

Željko Ivanek

Glenn Fleshler

Margot Verger

Katharine Isabelle

Grutas

Rhys Ifans

Lady Murasaki

Gong Li

Alan Bloom

Paul Perri  (as Sidney Bloom)

Caroline Dhavernas  (as Alana Bloom)

Beverly Katz

Michele Shay

Elizabeth Dennehy (as Beverly)

Hettienne Park

Jimmy Price

Dan Butler

Stanley Anderson

Scott Thompson

Brian Zeller

Chris Elliott  (as Zeller)

Aaron Abrams

Lloyd Bowman

Bill Smitrovich

Ken Leung

Chiyoh

Tao Okamoto

Bedelia Du Maurier

Gillian Anderson

Abel Gideon

Eddie Izzard

text: Critical reaction[edit]

text:
Film

Rotten Tomatoes

Metacritic

Manhunter

94% (33 reviews) [5]

78 (10 reviews) [6]

The Silence of the Lambs

95% (73 reviews) [7]

84 (17 reviews) [8]

Hannibal

39% (165 reviews) [9]

57 (36 reviews) [10]

Red Dragon

69% (185 reviews) [11]

60 (36 reviews) [12]

Hannibal Rising

15% (143 reviews) [13]

35 (30 reviews) [14]

Hannibal (TV series), Season 1 (2013)

71% (41 reviews) [15]

70 (32 reviews) [16]

Hannibal (TV series), Season 2 (2014)

100% (24 reviews) [17]

88 (14 reviews) [18]

Hannibal (TV series), Season 3 (2015)

97% (35 reviews) [19]

84 (15 reviews) [20]

text: Musical[edit]

text: In 2005, comedian-musicians Jon and Al Kaplan, most famous for their musical re-imaginings of popular films as YouTube musicals, parodied The Silence of the Lambs, especially the film version, in Silence! The Musical. It premiered Off-Off-Broadway and has since had acclaimed productions in London (2009) and Los Angeles (2012). In 2012, it won the Los Angeles Drama Critics Circle – Score, Lead Performance, Choreography Award.[21]