document_title: Shutdown of thermohaline circulation

question_text: when the conveyor belt ocean circulation stops winters in europe are much

root

text: Shutdown of thermohaline circulation

text: General[edit]

text: Don Chambers from the University of South Florida College of Marine Science mentioned, "The major effect of a slowing AMOC is expected to be cooler winters and summers around the North Atlantic, and small regional increases in sea level on the North American coast."[3] James Hansen and Makiko Sato stated,

tag: p

text: AMOC slowdown that causes cooling ~1°C and perhaps affects weather patterns is very different from an AMOC shutdown that cools the North Atlantic several degrees Celsius; the latter would have dramatic effects on storms and be irreversible on the century time scale.[4]

text: Downturn of the Atlantic meridional overturning circulation, has been tied to extreme regional sea level rise.[5]

text: Slowdown[edit]

text: Lohmann and Dima 2010 found a weakening of the AMOC since the late 1930s.[6] Climate scientists Michael Mann of Penn State and Stefan Rahmstorf from the Potsdam Institute for Climate Impact Research suggested that the observed cold pattern during years of temperature records is a sign that the Atlantic Ocean’s Meridional overturning circulation (AMOC) may be weakening. They published their findings in 2015, and concluded that the AMOC circulation showed exceptional slowdown in the last century, and that Greenland melt is a possible contributor, with the slowdown of AMOC since the 1970s being unprecedented over the last millennium.[7]

text: A study published in 2016 found further evidence for a considerable impact from sea level rise for the U.S. East Coast. The study confirms earlier research findings which identified the region as a hotspot for rising seas, with a potential to divert 3–4 times in the rate of rise, compared to the global average. The researchers attribute the possible increase to an ocean circulation mechanism called deep water formation, which is reduced due to AMOC slow down, leading to more warmer water pockets below the surface. Additionally, the study noted, "Our results suggest that higher carbon emission rates also contribute to increased [sea level rise] in this region compared to the global average."[8]

text: Shutdown[edit]

text:
Global warming could, via a shutdown of the thermohaline circulation, trigger cooling in the North Atlantic, Europe, and North America.[9][10] This would particularly affect areas such as the British Isles, France and the Nordic countries, which are warmed by the North Atlantic drift.[11][12] Major consequences, apart from regional cooling, could also include an increase in major floods and storms, a collapse of plankton stocks, warming or rainfall changes in the tropics or Alaska and Antarctica, more frequent and intense El Niño events due to associated shutdowns of the Kuroshio, Leeuwin, and East Australian Currents that are connected to the same thermohaline circulation as the Gulf Stream, or an oceanic anoxic event — oxygen (O
2) below surface levels of the stagnant oceans becomes completely depleted — a probable cause of past mass extinction events.[13]

text: Effects on weather[edit]

text: Hansen et al. 2015 found, that the shutdown or substantial slowdown of the AMOC, besides possibly contributing to extreme end-Eemian events, will cause a more general increase of severe weather. Additional surface cooling from ice melt increases surface and lower tropospheric temperature gradients, and causes in model simulations a large increase of mid-latitude eddy energy throughout the midlatitude troposphere. This in turn leads to an increase of baroclinicity produced by stronger temperature gradients, which provides energy for more severe weather events.

text: Many of the most memorable and devastating storms in eastern North America and western Europe, popularly known as superstorms, have been winter cyclonic storms, though sometimes occurring in late fall or early spring, that generate near-hurricane-force winds and often large amounts of snowfall. Continued warming of low latitude oceans in coming decades will provide more water vapor to strengthen such storms. If this tropical warming is combined with a cooler North Atlantic Ocean from AMOC slowdown and an increase in midlatitude eddy energy, we can anticipate more severe baroclinic storms.

text: Their results at least imply that strong cooling in the North Atlantic from AMOC shutdown does create higher wind speed. The increment in seasonal mean wind speed of the northeasterlies relative to preindustrial conditions is as much as 10–20 %. Such a percentage increase of wind speed in a storm translates into an increase of storm power dissipation by a factor ∼1.4–2, because wind power dissipation is proportional to the cube of wind speed. However, the simulated changes refer to seasonal mean winds averaged over large grid-boxes, not individual storms.[14]

text: Observations[edit]

text: 2010 and earlier[edit]

text: In April 2004, the hypothesis that the Gulf Stream is switching off received a boost when a retrospective analysis of U.S. satellite data seemed to show a slowing of the North Atlantic Gyre, the northern swirl of the Gulf Stream.[15]

text: In May 2005, Peter Wadhams reported in The Times (London) about the results of investigations in a submarine under the Arctic ice sheet measuring the giant chimneys of cold dense water, in which the cold dense water normally sinks down to the sea bed and is replaced by warm water, forming one of the engines of the North Atlantic Drift. He and his team found the chimneys to have virtually disappeared. Normally there are seven to twelve giant columns, but Wadhams found only two giant columns, both extremely weak.[16][17]

text: In 2005 a 30% reduction in the warm currents that carry water north from the Gulf Stream was observed, from the last such measurement in 1992. The authors noted uncertainties in the measurements.[18] Following media discussions, Detlef Quadfasel pointed out that the uncertainty of the estimates of Bryden et al. is high, but says other factors and observations do support their results, and implications based on palaeoclimate records show drops of air temperature up to 10 °C within decades, linked to abrupt switches of ocean circulation when a certain threshold is reached. He concluded that further observations and modelling are crucial for providing early warning of a possible devastating breakdown of the circulation.[19] In response Quirin Schiermeier concluded that natural variation were the culprit for the observations but highlighted possible implications.[13][20]

text: In 2008, Vage et al. reported "the return of deep convection to the subpolar gyre in both the Labrador and Irminger seas in the winter of 2007–2008," employing "profiling float data from the Argo program to document deep mixing," and "a variety of in situ, satellite and reanalysis data" to set the context for the phenomenon. This might have a lot to do with the observations of variations in cold water chimney behaviour.[21]

text: In January 2010, the Gulf Stream briefly connected with the West Greenland Current after fluctuating for a few weeks due to an extreme negative phase of the Arctic oscillation, temporarily diverting it west of Greenland.[22][23]

text: Thermohaline circulation and fresh water[edit]

text: Heat is transported from the equator polewards mostly by the atmosphere but also by ocean currents, with warm water near the surface and cold water at deeper levels. The best known segment of this circulation is the Gulf Stream, a wind-driven gyre, which transports warm water from the Caribbean northwards. A northwards branch of the Gulf Stream, the North Atlantic Drift, is part of the thermohaline circulation (THC), transporting warmth further north to the North Atlantic, where its effect in warming the atmosphere contributes to warming Europe. Other factors are also important, such as atmospheric waves that bring subtropical air further north, which have been suggested to influence the climate of the British Isles more than the Gulf Stream.[24][25]

text: The evaporation of ocean water in the North Atlantic increases the salinity of the water as well as cooling it, both actions increasing the density of water at the surface. Formation of sea ice further increases the salinity, because salt is ejected into the ocean when sea ice forms, which in turn increases the water's salinity. Because salt water is heavier, the density of the water increases.[26] This dense water then sinks and the circulation stream continues in a southerly direction. However, the Atlantic Meridional Overturning Circulation (AMOC) is driven by ocean temperature and salinity differences. But freshwater decreases ocean water salinity, and through this process prevents colder waters sinking. This mechanism possibly caused the cold ocean surface temperature anomaly currently observed near Greenland (Cold blob (North Atlantic)).[27]

text: Global warming could lead to an increase in freshwater in the northern oceans, by melting glaciers in Greenland, and by increasing precipitation, especially through Siberian rivers.[28][29]

text: An AMOC shutdown may be able to trigger the type of abrupt massive temperature shifts which occurred during the last glacial period: a series of Dansgaard-Oeschger events – rapid climate fluctuations – may be attributed to freshwater forcing at high latitude interrupting the THC. 2002 model runs in which the THC is forced to shut down do show cooling – locally up to 8 °C (14 °F).[30]

text: Studies of the Florida Current suggest that the Gulf Stream weakens with cooling, being weakest (by ~10%) during the Little Ice Age.[31]

text: Subpolar North Atlantic (SPG) convection collapse[edit]

text: Recent studies (2017) suggest potential convection collapse (heat transport) of the subpolar gyre in the North Atlantic, resulting in rapid cooling, with implications for economic sectors, agriculture industry, water resources and energy management in Western Europe and the East Coast of the United States.[32]

text: IPCC models[edit]

text: Based on coupled Atmosphere-Ocean General Circulation Models from 2001, the THC tends to weaken somewhat rather than stop, and the warming effects outweigh the cooling, even over Europe.[33] In the IPCC Fifth Assessment Report, it was reported that it is very unlikely that the AMOC will undergo a rapid transition (high confidence).[34][citation needed]

text: In popular culture[edit]

text: The film The Day After Tomorrow exaggerates a scenario related to the AMOC shutdown.


document_title: Dominance (genetics)

question_text: what type of genetics relationship produces traits utilizing 3 or more genes

text: Dominance (genetics)

text: Background[edit]

text: The concept of dominance was introduced by Gregor Johann Mendel. Though Mendel, "The Father of Genetics", first used the term in the 1860s, it was not widely known until the early twentieth century. Mendel observed that, for a variety of traits of garden peas having to do with the appearance of seeds, seed pods, and plants, there were two discrete phenotypes, such as round versus wrinkled seeds, yellow versus green seeds, red versus white flowers or tall versus short plants. When bred separately, the plants always produced the same phenotypes, generation after generation. However, when lines with different phenotypes were crossed (interbred), one and only one of the parental phenotypes showed up in the offspring (green, or round, or red, or tall). However, when these hybrid plants were crossed, the offspring plants showed the two original phenotypes, in a characteristic 3:1 ratio, the more common phenotype being that of the parental hybrid plants. Mendel reasoned that each parent in the first cross was a homozygote for different alleles (one parent AA and the other parent aa), that each contributed one allele to the offspring, with the result that all of these hybrids were heterozygotes (Aa), and that one of the two alleles in the hybrid cross dominated expression of the other: A masked a. The final cross between two heterozygotes (Aa X Aa) would produce AA, Aa, and aa offspring in a 1:2:1 genotype ratio with the first two classes showing the (A) phenotype, and the last showing the (a) phenotype, thereby producing the 3:1 phenotype ratio.

text: Mendel did not use the terms gene, allele, phenotype, genotype, homozygote, and heterozygote, all of which were introduced later. He did introduce the notation of capital and lowercase letters for dominant and recessive alleles, respectively, still in use today.

text: Chromosomes, genes, and alleles[edit]

text: Most animals and some plants have paired chromosomes, and are described as diploid. They have two versions of each chromosome, one contributed by the mother's ovum, and the other by the father's sperm, known as gametes, described as haploid, and created through meiosis. These gametes then fuse during fertilization during sexual reproduction, into a new single cell zygote, which divides multiple times, resulting in a new organism with the same number of pairs of chromosomes in each (non-gamete) cell as its parents.

text: Each chromosome of a matching (homologous) pair is structurally similar to the other, and has a very similar DNA sequence (loci, singular locus). The DNA in each chromosome functions as a series of discrete genes that influence various traits. Thus, each gene also has a corresponding homologue, which may exist in different versions called alleles. The alleles at the same locus on the two homologous chromosomes may be identical or different.

text: Blood types in humans is determined by a gene that creates an A, B, AB or O blood type and is located in the long arm of chromosome nine. There are three different alleles that could be present at this locus, but only two can be present in any individual, one inherited from their mother and one from their father.[4]

text: If two alleles of a given gene are identical, the organism is called a homozygote and is said to be homozygous with respect to that gene; if instead the two alleles are different, the organism is a heterozygote and is heterozygous. The genetic makeup of an organism, either at a single locus or over all its genes collectively, is called its genotype. The genotype of an organism directly and indirectly affects its molecular, physical, and other traits, which individually or collectively are called its phenotype. At heterozygous gene loci, the two alleles interact to produce the phenotype.

text: Dominance[edit]

text: Complete dominance[edit]

text: In complete dominance, the effect of one allele in a heterozygous genotype completely masks the effect of the other. The allele that masks the other is said to be dominant to the latter, and the allele that is masked is said to be recessive to the former.[5] Complete dominance, therefore, means that the phenotype of the heterozygote is indistinguishable from that of the dominant homozygote.

text: A classic example of dominance is the inheritance of seed shape (pea shape) in peas. Peas may be round (associated with allele R) or wrinkled (associated with allele r). In this case, three combinations of alleles (genotypes) are possible: RR and rr are homozygous and Rr is heterozygous. The RR individuals have round peas and the rr individuals have wrinkled peas. In Rr individuals the R allele masks the presence of the r allele, so these individuals also have round peas. Thus, allele R is completely dominant to allele r, and allele r is recessive to allele R.

text: Incomplete dominance[edit]

text: Incomplete dominance (also called partial dominance, semi-dominance or intermediate inheritance) occurs when the phenotype of the heterozygous genotype is distinct from and often intermediate to the phenotypes of the homozygous genotypes. For example, the snapdragon flower color is homozygous for either red or white. When the red homozygous flower is paired with the white homozygous flower, the result yields a pink snapdragon flower. The pink snapdragon is the result of incomplete dominance. A similar type of incomplete dominance is found in the four o'clock plant wherein pink color is produced when true-bred parents of white and red flowers are crossed. In quantitative genetics, where phenotypes are measured and treated numerically, if a heterozygote's phenotype is exactly between (numerically) that of the two homozygotes, the phenotype is said to exhibit no dominance at all, i.e. dominance exists only when the heterozygote's phenotype measure lies closer to one homozygote than the other.

text: When plants of the F1 generation are self-pollinated, the phenotypic and genotypic ratio of the F2 generation will be 1:2:1 (Red:Pink:White).[6]

text: See partial dominance hypothesis.

text: Co-dominance[edit]

text: Co-dominance occurs when the contributions of both alleles are visible in the phenotype.

text: For example, in the ABO blood group system, chemical modifications to a glycoprotein (the H antigen) on the surfaces of blood cells are controlled by three alleles, two of which are co-dominant to each other (IA, IB) and dominant over the recessive i at the ABO locus. The IA and IB alleles produce different modifications. The enzyme coded for by IA adds an N-acetylgalactosamine to the membrane-bound H antigen. The IB enzyme adds a galactose. The i allele produces no modification. Thus IA and IB alleles are each dominant to i (IAIA and IAi individuals both have type A blood, and IBIB and IBi individuals both have type B blood, but IAIB individuals have both modifications on their blood cells and thus have type AB blood, so the IA and IB alleles are said to be co-dominant).

text: Another example occurs at the locus for the Beta-globin component of hemoglobin, where the three molecular phenotypes of HbA/HbA, HbA/HbS, and HbS/HbS are all distinguishable by protein electrophoresis. (The medical condition produced by the heterozygous genotype is called sickle-cell trait and is a milder condition distinguishable from sickle-cell anemia, thus the alleles show incomplete dominance with respect to anemia, see above). For most gene loci at the molecular level, both alleles are expressed co-dominantly, because both are transcribed into RNA.

text: Co-dominance, where allelic products co-exist in the phenotype, is different from incomplete dominance, where the quantitative interaction of allele products produces an intermediate phenotype. For example, in co-dominance, a red homozygous flower and a white homozygous flower will produce offspring that have red and white spots. When plants of the F1 generation are self-pollinated, the phenotypic and genotypic ratio of the F2 generation will be 1:2:1 (Red:Spotted:White). These ratios are the same as those for incomplete dominance. Again, note that this classical terminology is inappropriate – in reality such cases should not be said to exhibit dominance at all.

text: Addressing common misconceptions[edit]

text: While it is often convenient to talk about a recessive allele or a dominant trait, dominance is not inherent to either an allele or its phenotype. Dominance is a relationship between two alleles of a gene and their associated phenotypes. A "dominant" allele is dominant to a particular allele of the same gene that can be inferred from the context, but it may be recessive to a third allele, and codominant to a fourth. Similarly, a "recessive" trait is a trait associated with a particular recessive allele implied by the context, but that same trait may occur in a different context where it is due to some other gene and a dominant allele.

text: Dominance is unrelated to the nature of the phenotype itself, that is, whether it is regarded as "normal" or "abnormal," "standard" or "nonstandard," "healthy" or "diseased," "stronger" or "weaker," or more or less extreme. A dominant or recessive allele may account for any of these trait types.

text: Dominance does not determine whether an allele is deleterious, neutral or advantageous. However, selection must operate on genes indirectly through phenotypes, and dominance affects the exposure of alleles in phenotypes, and hence the rate of change in allele frequencies under selection. Deleterious recessive alleles may persist in a population at low frequencies, with most copies carried in heterozygotes, at no cost to those individuals. These rare recessives are the basis for many hereditary genetic disorders.

text: Dominance is also unrelated to the distribution of alleles in the population. Some dominant alleles are extremely common, while others are extremely rare. The most common allele in a population may be recessive when combined with some rare variants.

text: Nomenclature[edit]

text: In genetics, symbols began as algebraic placeholders. When one allele is dominant to another, the oldest convention is to symbolize the dominant allele with a capital letter. The recessive allele is assigned the same letter in lower case. In the pea example, once the dominance relationship between the two alleles is known, it is possible to designate the dominant allele that produces a round shape by a capital-letter symbol R, and the recessive allele that produces a wrinkled shape by a lower-case symbol r. The homozygous dominant, heterozygous, and homozygous recessive genotypes are then written RR, Rr, and rr, respectively. It would also be possible to designate the two alleles as W and w, and the three genotypes WW, Ww, and ww, the first two of which produced round peas and the third wrinkled peas. Note that the choice of "R" or "W" as the symbol for the dominant allele does not pre-judge whether the allele causing the "round" or "wrinkled" phenotype when homozygous is the dominant one.

text: A gene may have several alleles. Each allele is symbolized by the locus symbol followed by a unique superscript. In many species, the most common allele in the wild population is designated the wild type allele. It is symbolized with a + character as a superscript. Other alleles are dominant or recessive to the wild type allele. For recessive alleles, the locus symbol is in lower case letters. For alleles with any degree of dominance to the wild type allele, the first letter of the locus symbol is in upper case. For example, here are some of the alleles at the a locus of the laboratory mouse, Mus musculus: Ay, dominant yellow; a+, wild type; and abt, black and tan. The abt allele is recessive to the wild type allele, and the Ay allele is codominant to the wild type allele. The Ay allele is also codominant to the abt allele, but showing that relationship is beyond the limits of the rules for mouse genetic nomenclature.

text: Rules of genetic nomenclature have evolved as genetics has become more complex. Committees have standardized the rules for some species, but not for all. Rules for one species may differ somewhat from the rules for a different species.[7][8]

text: Relationship to other genetic concepts[edit]

text: Multiple alleles[edit]

text: Although any individual of a diploid organism has at most two different alleles at any one locus (barring aneuploidies), most genes exist in a large number of allelic versions in the population as a whole. If the alleles have different effects on the phenotype, sometimes their dominance interactions with each other can be described as a series.

text: For example, coat color in domestic cats is affected by a series of alleles of the TYR gene (which encodes the enzyme tyrosinase). The alleles C, cb, cs, and ca (full colour, Burmese, Siamese, and albino, respectively) produce different levels of pigment and hence different levels of colour dilution. The C allele (full colour) is completely dominant over the last three and the ca allele (albino) is completely recessive to the first three. [9] [10] [11]

text: Autosomal versus sex-linked dominance[edit]

text: In humans and other mammal species, sex is determined by two sex chromosomes called the X chromosome and the Y chromosome. Human females are typically XX; males are typically XY. The remaining pairs of chromosome are found in both sexes and are called autosomes; genetic traits due to loci on these chromosomes are described as autosomal, and may be dominant or recessive. Genetic traits on the X and Y chromosomes are called sex-linked, because they are linked to sex chromosomes, not because they are characteristic of one sex or the other. In practice, the term almost always refers to X-linked traits and a great many such traits (such as red-green colour vision deficiency) are not affected by sex. Females have two copies of every gene locus found on the X chromosome, just as for the autosomes, and the same dominance relationships apply. Males however have only one copy of each X chromosome gene locus, and are described as hemizygous for these genes. The Y chromosome is much smaller than the X, and contains a much smaller set of genes, including, but not limited to, those that influence 'maleness', such as the SRY gene for testis determining factor. Dominance rules for sex-linked gene loci are determined by their behavior in the female: because the male has only one allele (except in the case of certain types of Y chromosome aneuploidy), that allele is always expressed regardless of whether it is dominant or recessive.

text: Epistasis[edit]

text: Epistasis ["epi + stasis = to sit on top"] is an interaction between alleles at two different gene loci that affect a single trait, which may sometimes resemble a dominance interaction between two different alleles at the same locus. Epistasis modifies the characteristic 9:3:3:1 ratio expected for two non-epistatic genes. For two loci, 14 classes of epistatic interactions are recognized. As an example of recessive epistasis, one gene locus may determine whether a flower pigment is yellow (AA or Aa) or green (aa), while another locus determines whether the pigment is produced (BB or Bb) or not (bb). In a bb plant, the flowers will be white, irrespective of the genotype of the other locus as AA, Aa, or aa. The bb combination is not dominant to the A allele: rather, the B gene shows recessive epistasis to the A gene, because the B locus when homozygous for the recessive allele (bb) suppresses phenotypic expression of the A locus. In a cross between two AaBb plants, this produces a characteristic 9:3:4 ratio, in this case of yellow : green : white flowers.

text: In dominant epistasis, one gene locus may determine yellow or green pigment as in the previous example: AA and Aa are yellow, and aa are green. A second locus determines whether a pigment precursor is produced (dd) or not (DD or Dd). Here, in a DD or Dd plant, the flowers will be colorless irrespective of the genotype at the A locus, because of the epistatic effect of the dominant D allele. Thus, in a cross between two AaDd plants, 3/4 of the plants will be colorless, and the yellow and green phenotypes are expressed only in dd plants. This produces a characteristic 12:3:1 ratio of white : yellow : green plants.

text: Supplementary epistasis occurs when two loci affect the same phenotype. For example, if pigment color is produced by CC or Cc but not cc, and by DD or Dd but not dd, then pigment is not produced in any genotypic combination with either cc or dd. That is, both loci must have at least one dominant allele to produce the phenotype. This produces a characteristic 9:7 ratio of pigmented to unpigmented plants. Complementary epistasis in contrast produces an unpigmented plant if and only if the genotype is cc and dd, and the characteristic ratio is 15:1 between pigmented and unpigmented plants.[12]

text: Classical genetics considered epistatic interactions between two genes at a time. It is now evident from molecular genetics that all gene loci are involved in complex interactions with many other genes (e.g., metabolic pathways may involve scores of genes), and that this creates epistatic interactions that are much more complex than the classic two-locus models.

text: Hardy-Weinberg principle (estimation of carrier frequency)[edit]

text:
The frequency of the heterozygous state (which is the carrier state for a recessive trait) can be estimated using the Hardy-Weinberg formula:

p

2

+
2
p
q
+

q

2

=
1

{\displaystyle p^{2}+2pq+q^{2}=1}

text: This formula applies to a gene with exactly two alleles and relates the frequencies of those alleles in a large population to the frequencies of their three genotypes in that population.

text: For example, if p is the frequency of allele A, and q is the frequency of allele a then the terms p2, 2pq, and q2 are the frequencies of the genotypes AA, Aa and aa respectively. Since the gene has only two alleles, all alleles must be either A or a and p + q = 1. Now, if A is completely dominant to a then the frequency of the carrier genotype Aa cannot be directly observed (since it has the same traits as the homozygous genotype AA), however it can be estimated from the frequency of the recessive trait in the population, since this is the same as that of the homozygous genotype aa. i.e. the individual allele frequencies can be estimated: q = √f(aa), p = 1 − q, and from those the frequency of the carrier genotype can be derived: f(Aa) = 2pq.

text: This formula relies on a number of assumptions and an accurate estimate of the frequency of the recessive trait. In general, any real-world situation will deviate from these assumptions to some degree, introducing corresponding inaccuracies into the estimate. If the recessive trait is rare, then it will be hard to estimate its frequency accurately, as a very large sample size will be needed.

text: Dominant versus advantageous[edit]

text: The property of "dominant" is sometimes confused with the concept of advantageous and the property of "recessive" is sometimes confused with the concept of deleterious, but the phenomena are distinct. Dominance describes the phenotype of heterozygotes with regard to the phenotypes of the homozygotes and without respect to the degree to which different phenotypes may be beneficial or deleterious. Since many genetic disease alleles are recessive and because the word dominance has a positive connotation, the assumption that the dominant phenotype is superior with respect to fitness is often made. This is not assured however; as discussed below while most genetic disease alleles are deleterious and recessive, not all genetic diseases are recessive.

text: Nevertheless, this confusion has been pervasive throughout the history of genetics and persists to this day. Addressing this confusion was one of the prime motivations for the publication of the Hardy-Weinberg principle.

text: Molecular mechanisms[edit]

text: The molecular basis of dominance was unknown to Mendel. It is now understood that a gene locus includes a long series (hundreds to thousands) of bases or nucleotides of deoxyribonucleic acid (DNA) at a particular point on a chromosome. The central dogma of molecular biology states that "DNA makes RNA makes protein", that is, that DNA is transcribed to make an RNA copy, and RNA is translated to make a protein. In this process, different alleles at a locus may or may not be transcribed, and if transcribed may be translated to slightly different versions of the same protein (called isoforms). Proteins often function as enzymes that catalyze chemical reactions in the cell, which directly or indirectly produce phenotypes. In any diploid organism, the DNA sequences of the two alleles present at any gene locus may be identical (homozygous) or different (heterozygous). Even if the gene locus is heterozygous at the level of the DNA sequence, the proteins made by each allele may be identical. In the absence of any difference between the protein products, neither allele can be said to be dominant (see co-dominance, above). Even if the two protein products are slightly different (allozymes), it is likely that they produce the same phenotype with respect to enzyme action, and again neither allele can be said to be dominant.

text: Loss of function and haplosufficiency[edit]

text: Dominance typically occurs when one of the two alleles is non-functional at the molecular level, that is, it is not transcribed or else does not produce a functional protein product. This can be the result of a mutation that alters the DNA sequence of the allele.[citation needed] An organism homozygous for the non-functional allele will generally show a distinctive phenotype, due to the absence of the protein product. For example, in humans and other organisms, the unpigmented skin of the albino phenotype[13] results when an individual is homozygous for an allele that encodes a non-functional version of an enzyme needed to produce the skin pigment melanin. It is important to understand that it is not the lack of function that allows the allele to be described as recessive: this is the interaction with the alternative allele in the heterozygote. Three general types of interaction are possible:

text:
In the typical case, the single functional allele makes sufficient protein to produce a phenotype identical to that of the homozygote: this is called haplosufficiency. For example, suppose the standard amount of enzyme produced in the functional homozygote is 100%, with the two functional alleles contributing 50% each. The single functional allele in the heterozygote produces 50% of the standard amount of enzyme, which is sufficient to produce the standard phenotype. If the heterozygote and the functional-allele homozygote have identical phenotypes, the functional allele is dominant to the non-functional allele. This occurs at the albino gene locus: the heterozygote produces sufficient enzyme to convert the pigment precursor to melanin, and the individual has standard pigmentation.
Less commonly, the presence of a single functional allele gives a phenotype that is not normal but less severe than that of the non-functional homozygote. This occurs when the functional allele is not haplo-sufficient. The terms haplo-insufficiency and incomplete dominance are typically applied to these cases. The intermediate interaction occurs where the heterozygous genotype produces a phenotype intermediate between the two homozygotes. Depending on which of the two homozygotes the heterozygote most resembles, one allele is said to show incomplete dominance over the other. For example, in humans the Hb gene locus is responsible for the Beta-chain protein (HBB) that is one of the two globin proteins that make up the blood pigment hemoglobin[13]. Many people are homozygous for an allele called HbA; some persons carry an alternative allele called HbS, either as homozygotes or heterozygotes. The hemoglobin molecules of HbS/HbS homozygotes undergo a change in shape that distorts the morphology of the red blood cells, and causes a severe, life-threatening form of anemia called sickle-cell anemia. Persons heterozygous HbA/HbS for this allele have a much less severe form of anemia called sickle-cell trait. Because the disease phenotype of HbA/HbS heterozygotes is more similar to but not identical to the HbA/HbA homozygote, the HbA allele is said to be incompletely dominant to the HbS allele.
Rarely, a single functional allele in the heterozygote may produce insufficient gene product for any function of the gene, and the phenotype resembles that of the homozygote for the non-functional allele. This complete haploinsufficiency is very unusual. In these cases the non-functional allele would be said to be dominant to the functional allele. This situation may occur when the non-functional allele produces a defective protein that interferes with the proper function of the protein produced by the standard allele. The presence of the defective protein "dominates" the standard protein, and the disease phenotype of the heterozygote more closely resembles that of the homozygote for two defective alleles. Note that the term dominant is often incorrectly applied to defective alleles whose homozygous phenotype has not been examined, but which cause a distinct phenotype when heterozygous with the normal allele. This phenomenon occurs in a number of trinucleotide repeat diseases, one example being Huntington's disease.[14]

tag: ol

text: Dominant-negative mutations[edit]

text: Many proteins are normally active in the form of a multimer, an aggregate of multiple copies of the same protein, otherwise known as a homomultimeric protein or homooligomeric protein. In fact, a majority of the 83,000 different enzymes from 9800 different organisms in the BRENDA Enzyme Database[15] represent homooligomers.[16] When the wild-type version of the protein is present along with a mutant version, a mixed multimer can be formed. A mutation that leads to a mutant protein that disrupts the activity of the wild-type protein in the multimer is a dominant-negative mutation.

text: A dominant-negative mutation may arise in a human somatic cell and provide a proliferative advantage to the mutant cell, leading to its clonal expansion. For instance, a dominant-negative mutation in a gene necessary for the normal process of programmed cell death (Apoptosis) in response to DNA damage can make the cell resistant to apoptosis. This will allow proliferation of the clone even when excessive DNA damage is present. Such dominant-negative mutations occur in the tumor suppressor gene p53.[17][18] The P53 wild-type protein is normally present as a four-protein multimer (oligotetramer). Dominant-negative p53 mutations occur in a number of different types of cancer and pre-cancerous lesions (e.g. brain tumors, breast cancer, oral pre-cancerous lesions and oral cancer).[17]

text: Dominant-negative mutations also occur in other tumor suppressor genes. For instance two dominant-negative germ line mutations were identified in the Ataxia telangiectasia mutated (ATM) gene which increases susceptibility to breast cancer.[19] Dominant negative mutations of the transcription factor C/EBPα can cause acute myeloid leukemia.[20] Inherited dominant negative mutations can also increase the risk of diseases other than cancer. Dominant-negative mutations in Peroxisome proliferator-activated receptor gamma (PPARγ) are associated with severe insulin resistance, diabetes mellitus and hypertension.[21]

text: Dominant-negative mutations have also been described in organisms other than humans. In fact, the first study reporting a mutant protein inhibiting the normal function of a wild-type protein in a mixed multimer was with the bacteriophage T4 tail fiber protein GP37.[22] Mutations that produce a truncated protein rather than a full-length mutant protein seem to have the strongest dominant-negative effect in the studies of P53, ATM, C/EBPα, and bacteriophage T4 GP37.

text: Dominant and recessive genetic diseases in humans[edit]

text: In humans, many genetic traits or diseases are classified simply as "dominant" or "recessive". Especially with so-called recessive diseases, which are indeed a factor of recessive genes, but can oversimplify the underlying molecular basis and lead to misunderstanding of the nature of dominance. For example, the recessive genetic disease phenylketonuria (PKU)[23] results from any of a large number (>60) of alleles at the gene locus for the enzyme phenylalanine hydroxylase (PAH).[24] Many of these alleles produce little or no PAH, as a result of which the substrate phenylalanine (Phe) and its metabolic byproducts accumulate in the central nervous system and can cause severe intellectual disability if untreated.

text: The genotypes and phenotypic consequences of interactions among three alleles are shown in the following table:[25]

text:
Genotype
PAH activity
[Phe] conc
PKU ?

AA
100%
60 uM
No

AB
30%
120 uM
No

CC
5%
200 ~ 300 uM
Hyperphenylalaninemia

BB
0.3%
600 ~ 2400 uM
Yes

tag: table

text: In unaffected persons homozygous for a standard functional allele (AA), PAH activity is standard (100%), and the concentration of phenylalanine in the blood [Phe] is about 60 uM. In untreated persons homozygous for one of the PKU alleles (BB), PAH activity is close to zero, [Phe] ten to forty times standard, and the individual manifests PKU.

text: In the AB heterozygote, PAH activity is only 30% (not 50%) of standard, blood [Phe] is elevated two-fold, and the person does not manifest PKU. Thus, the A allele is dominant to the B allele with respect to PKU, but the B allele is incompletely dominant to the A allele with respect to its molecular effect, determination of PAH activity level (0.3% < 30% << 100%). Finally, the A allele is an incomplete dominant to B with respect to [Phe], as 60 uM < 120 uM << 600 uM. Note once more that it is irrelevant to the question of dominance that the recessive allele produces a more extreme [Phe] phenotype.

text: For a third allele C, a CC homozygote produces a very small amount of PAH enzyme, which results in a somewhat elevated level of [Phe] in the blood, a condition called hyperphenylalaninemia, which does not result in intellectual disability.

text: That is, the dominance relationships of any two alleles may vary according to which aspect of the phenotype is under consideration. It is typically more useful to talk about the phenotypic consequences of the allelic interactions involved in any genotype, rather than to try to force them into dominant and recessive categories.


document_title: History of the Church of England

question_text: which monarch separated england from the catholic church

question_tokens: which monarch separated england from the catholic church

text: History of the Church of England

text: Roman and Sub-Roman Christianity in the British Isles[edit]

text: According to medieval traditions, Christianity arrived in Britain in the 1st or 2nd century, although stories involving Joseph of Arimathea, King Lucius, and Fagan are now usually accounted as pious forgeries. The earliest historical evidence of Christianity among the native Britons is found in the writings of such early Christian Fathers as Tertullian and Origen in the first years of the 3rd century, although the first Christian communities probably were established some decades earlier.

text: Three Romano-British bishops, including Restitutus, metropolitan bishop of London, are known to have been present at the Council of Arles (314). Others attended the Council of Serdica in 347 and that of Ariminum in 360. A number of references to the church in Roman Britain are also found in the writings of 4th century Christian fathers. Britain was the home of Pelagius, who opposed Augustine of Hippo's doctrine of original sin. The first recorded Christian martyr in Britain, St Alban, is thought to have lived in the early 4th century, and his prominence in English hagiography is reflected in the number of parish churches of which he is patron.

text: Irish Anglicans trace their origins back to the founding saint of Irish Christianity (St Patrick) who is believed to have been a Roman Briton and pre-dated Anglo-Saxon Christianity. Anglicans also consider Celtic Christianity a forerunner of their church, since the re-establishment of Christianity in some areas of Great Britain in the 6th century came via Irish and Scottish missionaries, notably followers of St Patrick and St Columba.[4]

text: Augustine and the Anglo-Saxon period[edit]

text: Anglicans traditionally date the origins of their Church to the arrival in the Kingdom of Kent of the Gregorian mission to the pagan Anglo-Saxons led by the first Archbishop of Canterbury, St Augustine, at the end of the 6th century. Alone among the kingdoms then existing Kent was Jutish, rather than Anglian or Saxon. However, the origin of the Church in the British Isles extends farther back (see above).

text: Æthelberht of Kent's queen Bertha, daughter of Charibert, one of the Merovingian kings of the Franks, had brought a chaplain (Liudhard) with her. Bertha had restored a church remaining from Roman times to the east of Canterbury and dedicated it to Saint Martin of Tours, the patronal saint of the Merovingian royal family. This church, Saint Martin's, is the oldest church in England still in use today. Æthelberht himself, though a pagan, allowed his wife to worship God in her own way, at St Martin's. Probably influenced by his wife, Æthelberht asked Pope Gregory I to send missionaries, and in 596 the Pope dispatched Augustine, together with a party of monks.

text: Augustine had served as praepositus (prior) of the monastery of Saint Andrew in Rome, founded by Gregory. His party lost heart on the way and Augustine went back to Rome from Provence and asked his superiors to abandon the mission project. The pope, however, commanded and encouraged continuation, and Augustine and his followers landed on the Island of Thanet in the spring of 597.

text: Æthelberht permitted the missionaries to settle and preach in his town of Canterbury, first in Saint Martin's Church and then nearby at what later became St Augustine's Abbey. By the end of the year he himself had been converted, and Augustine received consecration as a bishop at Arles. At Christmas 10,000 of the king's subjects underwent baptism.

text: Augustine sent a report of his success to Gregory with certain questions concerning his work. In 601 Mellitus, Justus and others brought the pope's replies, with the pallium for Augustine and a present of sacred vessels, vestments, relics, books, and the like. Gregory directed the new archbishop to ordain as soon as possible twelve suffragan bishops and to send a bishop to York, who should also have twelve suffragans. Augustine did not carry out this papal plan, nor did he establish the primatial see at London (in the Kingdom of the East Saxons) as Gregory intended, as the Londoners remained heathen. Augustine did consecrate Mellitus as bishop of London and Justus as bishop of Rochester.

text: Pope Gregory issued more practicable mandates concerning heathen temples and usages: he desired that temples become consecrated to Christian service and asked Augustine to transform pagan practices, so far as possible, into dedication ceremonies or feasts of martyrs, since "he who would climb to a lofty height must go up by steps, not leaps" (letter of Gregory to Mellitus, in Bede, i, 30).

text: Augustine re-consecrated and rebuilt an old church at Canterbury as his cathedral and founded a monastery in connection with it. He also restored a church and founded the monastery of St Peter and St Paul outside the walls. He died before completing the monastery, but now lies buried in the Church of St Peter and St Paul.

text: In 616 Æthelberht of Kent died. The kingdom of Kent and those Anglo-Saxon kingdoms over which Kent had influence relapsed into heathenism for several decades. During the next 50 years Celtic missionaries evangelised the kingdom of Northumbria with an episcopal see at Lindisfarne and missionaries then proceeded to some of the other kingdoms to evangelise those also. Mercia and Sussex were among the last kingdoms to undergo Christianization.

text: The Synod of Whitby in 664 forms a significant watershed in that King Oswiu of Northumbria decided to follow Roman rather than Celtic practices. The Synod of Whitby established the Roman date for Easter and the Roman style of monastic tonsure in Britain. This meeting of the ecclesiastics with Roman customs and local bishops following Celtic ecclesiastical customs was summoned in 664 at Saint Hilda's double monastery of Streonshalh (Streanæshalch), later called Whitby Abbey. It was presided over by King Oswiu, who did not engage in the debate but made the final ruling.

text: A later archbishop of Canterbury, the Greek Theodore of Tarsus, also contributed to the organisation of Christianity in England, reforming many aspects of the church's administration.

text: Medieval consolidation[edit]

text: As in other parts of medieval Europe, tension existed between the local monarch and the Pope about civil judicial authority over clerics, taxes and the wealth of the Church, and appointments of bishops, notably during the reigns of Henry II and John. As begun by Alfred the Great in 871 and consolidated under William the Conqueror in 1066, England became a politically unified entity at an earlier date than other European countries. One of the effects was that the units of government, both of church and state, were comparatively large. England was divided between the Province of Canterbury and the Province of York under two archbishops. At the time of the Norman Conquest, there were only 15 diocesan bishops in England, increased to 17 in the 12th century with the creation of the sees of Ely and Carlisle. This is far fewer than the numbers in France and Italy.[5] A further four medieval dioceses in Wales came within the Province of Canterbury. Following the depredations of the Viking invasions of the 9th century, most English monasteries had ceased to function and the cathedrals were typically served by small communities of married priests. King Edgar and his Archbishop of Canterbury Dunstan instituted a major reform of cathedrals at a synod at Winchester in 970, where it was agreed that all bishops should seek to establish monasticism in their cathedrals following the Benedictine rule, with the bishop as abbot. Excavations have demonstrated that the reformed monastic cathedrals of Canterbury, Winchester, Sherborne and Worcester were rebuilt on a lavish scale in the late 10th century. However, renewed Viking attacks in the reign of Ethelred, stalled the progress of monastic revival.

text: In 1072, following the Norman Conquest, William the Conqueror and his archbishop Lanfranc sought to complete the programme of reform. Durham and Rochester cathedrals were refounded as Benedictine monasteries, the secular cathedral of Wells was moved to monastic Bath, while the secular cathedral of Lichfield was moved to Chester, and then to monastic Coventry. Norman bishops were seeking to establish an endowment income entirely separate from that of their cathedral body, and this was inherently more difficult in a monastic cathedral, where the bishop was also titular abbot. Hence, following Lanfanc's death in 1090, a number of bishops took advantage of the vacancy to obtain secular constitutions for their cathedrals – Lincoln, Sarum, Chichester, Exeter and Hereford; while the major urban cathedrals of London and York always remained secular. Furthermore, when the bishops' seats were transferred back from Coventry to Lichfield, and from Bath to Wells, these sees reverted to being secular. Bishops of monastic cathedrals, tended to find themselves embroiled in long-running legal disputes with their respective monastic bodies; and increasingly tended to reside elsewhere. The bishops of Ely and Winchester lived in London as did the Archbishop of Canterbury. The bishops of Worcester generally lived in York, while the bishops of Carlisle lived at Melbourne in Derbyshire. Monastic governance of cathedrals continued in England, Scotland and Wales throughout the medieval period; whereas elsewhere in western Europe it was found only at Monreale in Sicily and Downpatrick in Ireland.

text: An important aspect in the practice of medieval Christianity was the veneration of saints, and the associated pilgrimages to places where the relics of a particular saint were interred and the saint's tradition honoured. The possession of the relics of a popular saint was a source of funds to the individual church as the faithful made donations and benefactions in the hope that they might receive spiritual aid, a blessing or a healing from the presence of the physical remains of the holy person. Among those churches to benefit in particular were: St. Alban's Abbey, which contained the relics of England's first Christian martyr; Ripon, with the shrine of its founder St. Wilfrid; Durham, which was built to house the body of Saints Cuthbert of Lindisfarne and Aidan; Ely, with the shrine of St. Etheldreda; Westminster Abbey, with the magnificent shrine of its founder St. Edward the Confessor; and Chichester, which held the honoured remains of St. Richard. All these saints brought pilgrims to their churches, but among them the most renowned was Thomas Becket, the late Archbishop of Canterbury, who was assassinated by henchmen of King Henry II in 1170. As a place of pilgrimage Canterbury was, in the 13th century, second only to Santiago de Compostela.

text: Separation from Papal authority[edit]

text: John Wycliffe (about 1320 – 31 December 1384) was an English theologian and an early dissident against the Roman Catholic Church during the 14th century. He founded the Lollard movement, which opposed a number of practices of the Church. He was also against papal encroachments on secular power. Wycliffe was associated with statements indicating that the Church in Rome is not the head of all churches, nor did St Peter have any more powers given to him than other disciples. These statements were related to his call for a reformation of its wealth, corruption and abuses. Wycliffe, an Oxford scholar, went so far as to state that "... The Gospel by itself is a rule sufficient to rule the life of every Christian person on the earth, without any other rule."[citation needed] The Lollard movement continued with his pronouncements from pulpits even under the persecution that followed with Henry IV up to and including the early years of the reign of Henry VIII.

text: The first break with Rome (subsequently reversed) came when Pope Clement VII refused, over a period of years, to annul Henry's marriage to Catherine of Aragon, not purely as a matter of principle, but also because the Pope lived in fear of Catherine's nephew, Charles V, Holy Roman Emperor, as a result of events in the Italian Wars.[citation needed]

text: Henry first asked for an annulment in 1527. After various failed initiatives he stepped up the pressure on Rome, in the summer of 1529, by compiling a manuscript from ancient sources arguing that, in law, spiritual supremacy rested with the monarch and also against the legality of Papal authority. In 1531 Henry first challenged the Pope when he demanded 100,000 pounds from the clergy in exchange for a royal pardon for what he called their illegal jurisdiction. He also demanded that the clergy should recognise him as their sole protector and supreme head. The church in England recognised Henry VIII as supreme head of the Church of England on 11 February 1531. Nonetheless, he continued to seek a compromise with the Pope, but negotiations (which had started in 1530 and ended in 1532) with the papal legate Antonio Giovanni da Burgio failed. Efforts by Henry to appeal to Jewish scholarship concerning the contours of levirate marriage were unavailing as well.

text: In May 1532 the Church of England agreed to surrender its legislative independence and canon law to the authority of the monarch. In 1533 the Statute in Restraint of Appeals removed the right of the English clergy and laity to appeal to Rome on matters of matrimony, tithes and oblations. It also gave authority over such matters to the Archbishops of Canterbury and York. This finally allowed Thomas Cranmer, the new Archbishop of Canterbury, to issue Henry's annulment; and upon procuring it, Henry married Anne Boleyn. Pope Clement VII excommunicated Henry VIII in 1533.

text: In 1534 the Act of Submission of the Clergy removed the right of all appeals to Rome, effectively ending the Pope's influence. The first Act of Supremacy confirmed Henry by statute as the Supreme Head of the Church of England in 1536. (Due to clergy objections the contentious term "Supreme Head" for the monarch later became "Supreme Governor of the Church of England" – which is the title held by the reigning monarch to the present.)

text: Such constitutional changes made it not only possible for Henry to have his marriage annulled but also gave him access to the considerable wealth that the Church had amassed. Thomas Cromwell, as Vicar General, launched a commission of enquiry into the nature and value of all ecclesiastical property in 1535, which culminated in the Dissolution of the Monasteries (1536 – 1540).

text: Reformation[edit]

text: Many Roman Catholics consider the separation of the Church in England from Rome in 1534 to be the true origin of the Church of England, rather than dating it from the mission of St. Augustine in AD 597. While Anglicans acknowledge that Henry VIII's repudiation of papal authority caused the Church of England to become a separate entity, they believe that it is in continuity with the pre-Reformation Church of England. Apart from its distinct customs and liturgies (such as the Sarum rite), the organizational machinery of the Church of England was in place by the time of the Synod of Hertford in 672 – 673, when the English bishops were first able to act as one body under the leadership of the Archbishop of Canterbury. Henry's Act in Restraint of Appeals (1533) and the Acts of Supremacy (1534) declared that the English crown was "the only Supreme Head in earth of the Church of England, called Ecclesia Anglicana," in order "to repress and extirpate all errors, heresies, and other enormities and abuses heretofore used in the same." The development of the Thirty-Nine Articles of religion and the passage of the Acts of Uniformity culminated in the Elizabethan Religious Settlement. By the end of the 17th century, the English church described itself as both Catholic and Reformed, with the English monarch as its Supreme Governor.[6] MacCulloch commenting on this situation says that it "has never subsequently dared to define its identity decisively as Protestant or Catholic, and has decided in the end that this is a virtue rather than a handicap."[7]

text: King Henry VIII of England[edit]

text: The English Reformation was initially driven by the dynastic goals of Henry VIII, who, in his quest for a consort who would bear him a male heir, found it expedient to replace papal authority with the supremacy of the English crown. The early legislation focused primarily on questions of temporal and spiritual supremacy. The Institution of the Christian Man (also called The Bishops' Book) of 1537 was written by a committee of 46 divines and bishops headed by Thomas Cranmer. The purpose of the work, along with the Ten Articles of the previous year, was to implement the reforms of Henry VIII in separating from the Roman Catholic Church and reforming the Ecclesia Anglicana.[b] "The work was a noble endeavor on the part of the bishops to promote unity, and to instruct the people in Church doctrine."[9] The introduction of the Great Bible in 1538 brought a vernacular translation of the Scriptures into churches. The Dissolution of the Monasteries and the seizure of their assets by 1540 brought huge amounts of church land and property under the jurisdiction of the Crown, and ultimately into the hands of the English nobility. This simultaneously removed the greatest centres of loyalty to the pope and created vested interests which made a powerful material incentive to support a separate Christian church in England under the rule of the Crown.

text: Cranmer, Parker and Hooker[edit]

text: By 1549, the process of reforming the ancient national church was fully spurred on by the publication of the first vernacular prayer book, the Book of Common Prayer, and the enforcement of the Acts of Uniformity, establishing English as the language of public worship. The theological justification for Anglican distinctiveness was begun by the Thomas Cranmer, Archbishop of Canterbury, the principal author of the first prayer book, and continued by others such as Matthew Parker, Richard Hooker and Lancelot Andrewes. Cranmer had worked as a diplomat in Europe and was aware of the ideas of Reformers such as Andreas Osiander and Friedrich Myconius as well as the Roman Catholic theologian Desiderius Erasmus.

text: During the short reign of Edward VI, Henry's son, Cranmer and others moved the Church of England significantly towards a more reformed position, which was reflected in the development of the second prayer book (1552) and in the Forty-Two Articles. This reform was reversed abruptly in the reign of Queen Mary, a Roman Catholic who re-established communion with Rome following her accession in 1553.

text: In the 16th century, religious life was an important part of the cement which held society together and formed an important basis for extending and consolidating political power. Differences in religion were likely to lead to civil unrest at the very least, with treason and foreign invasion acting as real threats. When Queen Elizabeth came to the throne in 1558, a solution was thought to have been found. To minimise bloodshed over religion in her dominions, the religious settlement between the factions of Rome and Geneva was brought about. It was compellingly articulated in the development of the 1559 Book of Common Prayer, the Thirty-Nine Articles, the Ordinal, and the two Books of Homilies. These works, issued under Archbishop Matthew Parker, were to become the basis of all subsequent Anglican doctrine and identity.[6]

text: The new version of the prayer book was substantially the same as Cranmer's earlier versions. It would become a source of great argument during the 17th century, but later revisions were not of great theological importance.[6] The Thirty-Nine Articles were based on the earlier work of Cranmer, being modelled after the Forty-Two Articles.

text: The bulk of the population acceded to Elizabeth's religious settlement with varying degrees of enthusiasm or resignation. It was imposed by law, and secured Parliamentary approval only by a narrow vote in which all the Roman Catholic bishops who were not imprisoned voted against. As well as those who continued to recognise papal supremacy, the more militant Protestants, or Puritans as they became known, opposed it. Both groups were punished and disenfranchised in various ways and cracks in the facade of religious unity in England appeared.

text:
Part of a series on

Reformation

Ninety-five Theses

Precursors[show]

Arnold of Brescia and Arnoldists
Peter Waldo and Waldensians
Girolamo Savonarola
John Wycliffe and Lollardy
William Tyndale
Jan Hus and Hussites

Beginning[show]

Ninety-five Theses
Diet of Worms
Luther Bible
Iconoclasm
Magisterials
Radicals

Contributing factors[show]

Western Schism
Avignon Papacy
Bohemian Reformation
Northern Renaissance
Humanism
Johann Reuchlin
German mysticism
Johannes Gutenberg and his printing press
Erasmus
Propaganda
Art

Theologies of seminal figures[show]

Theology of Martin Luther
Theology of Huldrych Zwingli
Theology of John Calvin

Protestant Reformers[show]

Martin Luther
Philip Melanchthon
Huldrych Zwingli
John Calvin
Martin Bucer
Theodore Beza
Heinrich Bullinger
Peter Martyr Vermigli
William Farel
John Knox
Roger Williams
Thomas Müntzer
Balthasar Hubmaier
Andreas Karlstadt
Menno Simons
Thomas Cranmer
Richard Hooker
Many others

Major political leaders[show]

Henry VIII of England
Elizabeth I of England
Oliver Cromwell
James VI and I
William the Silent
Gaspard II de Coligny
Henry IV of France
Jeanne d'Albret
Stephen Bocskai
Gabriel Bethlen
Gustav II Adolf
Frederick V, Elector Palatine
Philip I of Hesse
Frederick III, Elector of Saxony
John Frederick I, Elector of Saxony

By location[show]

Germany
Switzerland (Geneva/Zürich)
England
Scotland
Netherlands
Czech Lands
Slovakia
Hungary
Romania
Slovenia
Denmark–Norway and Holstein
Sweden and Finland
Iceland
Estonia and Latvia
Austria
France
Italy
Poland-Lithuania
Ireland

Political and religious conflicts[show]

Thirty Years' War
French Wars of Religion
Eighty Years' War
War of the Three Kingdoms
German Peasants' War
Wars of Kappel
Schmalkaldic War

Opposition[show]

Catholic Church
Council of Trent
Anti-Protestantism
Criticism of Protestantism
Charles V, Holy Roman Emperor

Conclusion[show]

Peace of Westphalia
Rise of Pietism
No end thesis

Commemoration[show]

Reformation Day
Reformation Wall
Lutheran commemorations
Anglican commemorations

Protestantism

v
t
e

text: Despite separation from Rome, the Church of England under Henry VIII remained essentially Catholic rather than Protestant in nature. Pope Leo X had earlier awarded to Henry himself the title of fidei defensor (defender of the faith), partly on account of Henry's attack on Lutheranism.[c] Some Protestant-influenced changes under Henry included a limited iconoclasm, the abolition of pilgrimages, and pilgrimage shrines, chantries, and the extinction of many saints' days. However, only minor changes in liturgy occurred during Henry's reign, and he carried through the Six Articles of 1539 which reaffirmed the Catholic nature of the church.

text: All this took place, however, at a time of major religious upheaval in Western Europe associated with the Reformation; once the schism had occurred, some reform probably became inevitable.

text: Only under Henry's son Edward VI (reigned 1547 – 1553) did the first major changes in parish activity take place, including translation and thorough revision of the liturgy along more Protestant lines. The resulting Book of Common Prayer, issued in 1549 and revised in 1552, came into use by the authority of the Parliament of England.

text: Reunion with Rome[edit]

text: Following the death of Edward, his half-sister the Roman Catholic Mary I (reigned 1553 – 1558) came to the throne. She renounced the Henrician and Edwardian changes, first by repealing her brother's reforms then by re-establishing unity with Rome. The Marian Persecutions of Protestants and dissenters took place at this time. The queen's image after the persecutions turned into that of an almost legendary tyrant called Bloody Mary. This view of Bloody Mary was mainly due to the widespread publication of Foxe's Book of Martyrs during her successor Elizabeth I's reign.

text: Nigel Heard summarises the persecution thus: "It is now estimated that the 274 religious executions carried out during the last three years of Mary's reign exceeded the number recorded in any Catholic country on the continent in the same period."[10]

text: Second schism[edit]

text: The second schism, from which the present Church of England originates, came later. Upon Mary's death in 1558, her half-sister Elizabeth I (reigned 1558 – 1603) came to power. Elizabeth became a determined opponent of papal control and re-introduced separatist ideas. In 1559, Parliament recognised Elizabeth as the Church's supreme governor, with a new Act of Supremacy that also repealed the remaining anti-Protestant legislation. A new Book of Common Prayer appeared in the same year. Elizabeth presided over the "Elizabethan Settlement", an attempt to satisfy the Puritan and Catholic forces in England within a single national Church. Elizabeth was eventually excommunicated on 25 February 1570 by Pope Pius V, finally breaking communion between Rome and the Anglican Church.

text: King James Bible[edit]

text: Shortly after coming to the throne, James I attempted to bring unity to the Church of England by instituting a commission consisting of scholars from all views within the Church to produce a unified and new translation of the Bible free of Calvinist and Popish influence. The project was begun in 1604 and completed in 1611 becoming de facto the Authorised Version in the Church of England and later other Anglican churches throughout the communion until the mid-20th century. The New Testament was translated from the Textus Receptus (Received Text) edition of the Greek texts, so called because most extant texts of the time were in agreement with it.

text: The Old Testament was translated from the Masoretic Hebrew text, while the Apocrypha was translated from the Greek Septuagint (LXX). The work was done by 47 scholars working in six committees, two based in each of the University of Oxford, the University of Cambridge, and Westminster. They worked on certain parts separately; then the drafts produced by each committee were compared and revised for harmony with each other.

text: This translation had a profound effect on English literature. The works of famous authors such as John Milton, Herman Melville, John Dryden and William Wordsworth are deeply inspired by it.

text: The Authorised Version is often referred to as the King James Version, particularly in the United States. King James was not personally involved in the translation, though his authorisation was legally necessary for the translation to begin, and he set out guidelines for the translation process, such as prohibiting footnotes and ensuring that Anglican positions were recognised on various points. A dedication to James by the translators still appears at the beginning of modern editions.

text: English Civil War[edit]

text: For the next century, through the reigns of James I and Charles I, and culminating in the English Civil War and the protectorate of Oliver Cromwell, there were significant swings back and forth between two factions: the Puritans (and other radicals) who sought more far-reaching reform, and the more conservative churchmen who aimed to keep closer to traditional beliefs and practices. The failure of political and ecclesiastical authorities to submit to Puritan demands for more extensive reform was one of the causes of open warfare. By continental standards the level of violence over religion was not high, but the casualties included a king, Charles I and an Archbishop of Canterbury, William Laud. For about a decade (1647 – 1660), Christmas was another casualty as Parliament abolished all feasts and festivals of the Church to rid England of outward signs of Popishness. Under the Protectorate of the Commonwealth of England from 1649 to 1660, Anglicanism was disestablished, presbyterian ecclesiology was introduced as an adjunct to the Episcopal system, the Articles were replaced with a non-Presbyterian version of the Westminster Confession (1647), and the Book of Common Prayer was replaced by the Directory of Public Worship.

text: Despite this, about one quarter of English clergy refused to conform. In the midst of the apparent triumph of Calvinism, the 17th century brought forth a Golden Age of Anglicanism.[6] The Caroline Divines, such as Andrewes, Laud, Herbert Thorndike, Jeremy Taylor, John Cosin, Thomas Ken and others rejected Roman claims and refused to adopt the ways and beliefs of the Continental Protestants.[6] The historic episcopate was preserved. Truth was to be found in Scripture and the bishops and archbishops, which were to be bound to the traditions of the first four centuries of the Church's history. The role of reason in theology was affirmed.[6]

text: Restoration and beyond[edit]

text: With the Restoration of Charles II, Anglicanism too was restored in a form not far removed from the Elizabethan version. One difference was that the ideal of encompassing all the people of England in one religious organisation, taken for granted by the Tudors, had to be abandoned. The 1662 revision of the Book of Common Prayer became the unifying text of the ruptured and repaired Church after the disaster that was the civil war.

text: When the new king Charles II reached the throne in 1660, he actively appointed his supporters who had resisted Cromwell to vacancies. He translated the leading supporters to the most prestigious and rewarding sees. He also considered the need to reestablish episcopal authority and to reincorporate "moderate dissenters" in order to effect Protestant reconciliation. In some cases turnover was heavy--he made four appointments to the diocese of Worcester in four years 1660-63, moving the first three up to better positions.[11]

text: Glorious Revolution and Act of Toleration[edit]

text: James II was overthrown by William of Orange in 1688, and the new king moved quickly to ease religious tensions. Many of his supporters had been Nonconformist non-Anglicans. With the Act of Toleration enacted on 24 May 1689, Nonconformists had freedom of worship. That is, those Protestants who dissented from the Church of England such as Baptists, Congregationalists and Quakers were allowed their own places of worship and their own teachers and preachers, subject to acceptance of certain oaths of allegiance. These privileges expressly did not apply to Catholics and Unitarians, and it continued the existing social and political disabilities for dissenters, including exclusion from political office. The religious settlement of 1689 shaped policy down to the 1830s.[12][13] The Church of England was not only dominant in religious affairs, but it blocked outsiders from responsible positions in national and local government, business, professions and academe. In practice, the doctrine of the divine right of kings persisted[14] Old animosities had diminished, and a new spirit of toleration was abroad. Restrictions on Nonconformists were mostly either ignored or slowly lifted. The Protestants, including the Quakers, who worked to overthrow King James II were rewarded. The Toleration Act of 1689 allowed nonconformists who have their own chapels, teachers, and preachers, censorship was relaxed. The religious landscape of England assumed its present form, with an Anglican established church occupying the middle ground, and Roman Catholics and those Puritans who dissented from the establishment, too strong to be suppressed altogether, having to continue their existence outside the national church rather than controlling it. [15]

text: 18th century[edit]

text: This section needs expansion. You can help by adding to it. (September 2010)

text: Spread of Anglicanism outside England[edit]

text: The history of Anglicanism since the 17th century has been one of greater geographical and cultural expansion and diversity, accompanied by a concomitant diversity of liturgical and theological profession and practice.

text: At the same time as the English reformation, the Church of Ireland was separated from Rome and adopted articles of faith similar to England's Thirty-Nine Articles. However, unlike England, the Anglican church there was never able to capture the loyalty of the majority of the population (who still adhered to Roman Catholicism). As early as 1582, the Scottish Episcopal Church was inaugurated when James VI of Scotland sought to reintroduce bishops when the Church of Scotland became fully presbyterian (see Scottish reformation). The Scottish Episcopal Church enabled the creation of the Episcopal Church in the United States of America after the American Revolution, by consecrating in Aberdeen the first American bishop, Samuel Seabury, who had been refused consecration by bishops in England, due to his inability to take the oath of allegiance to the English crown prescribed in the Order for the Consecration of Bishops. The polity and ecclesiology of the Scottish and American churches, as well as their daughter churches, thus tends to be distinct from those spawned by the English church—reflected, for example, in their looser conception of provincial government, and their leadership by a presiding bishop or primus rather than by a metropolitan or archbishop. The names of the Scottish and American churches inspire the customary term Episcopalian for an Anglican; the term being used in these and other parts of the world. See also: American Episcopalians, Scottish Episcopalians

text: At the time of the English Reformation the four (now six) Welsh dioceses were all part of the Province of Canterbury and remained so until 1920 when the Church in Wales was created as a province of the Anglican Communion. The intense interest in the Christian faith which characterised the Welsh in the 18th and 19th centuries was not present in the sixteenth and most Welsh people went along with the church's reformation more because the English government was strong enough to impose its wishes in Wales rather than out of any real conviction.

text: Anglicanism spread outside of the British Isles by means of emigration as well as missionary effort. The 1609 wreck of the flagship of the Virginia Company, the Sea Venture, resulted in the settlement of Bermuda by that Company. This was made official in 1612, when the town of St George's, now the oldest surviving English settlement in the New World, was established. It is the location of St Peter's Church, the oldest-surviving Anglican church outside the British Isles (Britain and Ireland), and the oldest surviving non-Roman Catholic church in the New World, also established in 1612. It remained part of the Church of England until 1978, when the Anglican Church of Bermuda separated. The Church of England was the state religion in Bermuda and a system of parishes was set up for the religious and political subdivision of the colony (they survive, today, as both civil and religious parishes). Bermuda, like Virginia, tended to the Royalist side during the Civil War. The conflict in Bermuda resulted in the expulsion of Independent Puritans from the island (the Eleutheran Adventurers, who settled Eleuthera, in the Bahamas). The church in Bermuda, before the Civil War, had a somewhat Presbyterian flavour, but mainstream Anglicanism was asserted afterwards (although Bermuda is also home to the oldest Presbyterian church outside the British Isles). Bermudians were required by law in the 17th century to attend Church of England services, and proscriptions similar to those in England existed on other denominations.

text: English missionary organisations such as USPG—then known as the Society for the Propagation of the Gospel in Foreign Parts, the Society for the Promotion of Christian Knowledge (SPCK) and the Church Missionary Society (CMS) were established in the 17th and 18th centuries to bring Anglican Christianity to the British colonies. By the 19th century, such missions were extended to other areas of the world. The liturgical and theological orientations of these missionary organisations were diverse. The SPG, for example, was in the 19th century influenced by the Catholic Revival in the Church of England, while the CMS was influenced by the Evangelicalism of the earlier Evangelical Revival. As a result, the piety, liturgy, and polity of the indigenous churches they established came to reflect these diverse orientations.

text: 19th century and after[edit]

text: The Plymouth Brethren seceded from the established church in the 1820s. The church in this period was affected by the Evangelical revival and the growth of industrial towns in the Industrial Revolution. There was an expansion of the various Nonconformist churches, notably Methodism. From the 1830s the Oxford Movement became influential and occasioned the revival of Anglo-Catholicism. From 1801 the Church of England and the Church of Ireland were unified and this situation lasted until the disestablishment of the Irish church in 1871 (by the Irish Church Act, 1869).

text: The growth of the twin "revivals" in 19th century Anglicanism-—Evangelical and Catholic-—was hugely influential. The Evangelical Revival informed important social movements such as the abolition of slavery, child welfare legislation, prohibition of alcohol, the development of public health and public education. It led to the creation of the Church Army, an evangelical and social welfare association and informed piety and liturgy, most notably in the development of Methodism.

text: The Catholic Revival had a more penetrating impact by transforming the liturgy of the Anglican Church, repositioning the Eucharist as the central act of worship in place of the daily offices, and reintroducing the use of vestments, ceremonial, and acts of piety (such as Eucharistic adoration) that had long been prohibited in the English church and (to a certain extent) in its daughter churches. It influenced Anglican theology, through such Oxford Movement figures as John Henry Newman, Edward Pusey, as well as the Christian socialism of Charles Gore and Frederick Maurice. Much work was done to introduce a more medieval style of church furnishing in many churches. Neo-Gothic in many different forms became the norm rather than the earlier Neo-Classical forms. Both revivals led to considerable missionary efforts in parts of the British Empire.

text: Prime ministers and the Queen[edit]

text: Patronage continued to play a central role in Church affairs. Not since Newcastle,[16] over a century before, did a prime minister pay as much attention to church vacancies as William Ewart Gladstone. He annoyed Queen Victoria by making appointments she did not like. He worked to match the skills of candidates to the needs of specific church offices. He supported his party by favouring Liberals who would support his political positions.[17] His counterpart, Disraeli, favoured Conservative bishops to a small extent, but took care to distribute bishoprics so as to balance various church factions. He occasionally sacrificed party advantage to choose a more qualified candidate. On most issues Disraeli and Queen Victoria were close, but they frequently clashed over church nominations because of her aversion to high churchmen.[18]

text: This section needs expansion. You can help by adding to it. (October 2010)

text: The current form of military chaplain dates from the era of the First World War. A chaplain provides spiritual and pastoral support for service personnel, including the conduct of religious services at sea or in the field. The Army Chaplains Department was granted the prefix "Royal" in recognition of the chaplains' wartime service. The Chaplain General of the British Army was Bishop John Taylor Smith who held the post from 1901 to 1925.[19]

text: An attempt to revise the Book of Common Prayer in 1928 was nullified by opposition in the House of Commons.[20]

text: During the Second World War the head of chaplaincy in the British Army was an (Anglican) chaplain-general, the Very Revd Charles Symons (with the military rank of major-general), who was formally under the control of the Permanent Under-Secretary of State. An assistant chaplain-general was a chaplain 1st class (full colonel), and a senior chaplain was a chaplain 2nd class (lieutenant colonel).[21]

text: A movement towards unification with the Methodist Church in the 1960s failed to pass through all the required stages on the Anglican side, being rejected by the General Synod in 1972. This was initiated by the Methodists and welcomed on the part of the Anglicans but full agreement on all points could not be reached.

text: The Church Assembly was replaced by the General Synod in 1970.

text: On 12 March 1994 the Church of England ordained its first female priests. On 11 July 2005 a vote was passed by the Church of England's General Synod in York to allow women's ordination as bishops. Both of these events were subject to opposition from some within the church who found difficulties in accepting them. Adjustments had to be made in the diocesan structure to accommodate those parishes unwilling to accept the ministry of women priests. (See women's ordination)

text: The first black archbishop of the Church of England, John Sentamu, formerly of Uganda, was enthroned on 30 November 2005 as Archbishop of York.

text: In 2006 the Church of England at its General Synod made a public apology for the institutional role it played as a historic owner of slave plantations in Barbados and Barbuda. The Reverend Simon Bessant recounted the history of the church on the island of Barbados, West Indies, where through a charitable bequest received in 1710 by the Society for the Propagation of the Gospel, thousands of sugar plantation slaves had been appallingly treated and branded using red-hot irons as the property of the "society".[22]

text: In 2010, for the first time in the history of the Church of England, more women than men were ordained as priests (290 women and 273 men).[23]


document_title: List of Indian Premier League records and statistics

question_text: most sixes hit by a batsman in ipl

question_tokens: most sixes hit by a batsman in ipl

text: Team records

text: Results summary

text:
Team
Span
Mat
Won
Lost
Tie+W
Tie+L
NR
Win %
Titles

Mumbai Indians
2008–2018
171
97
73
1
0
0
57.01
3

Royal Challengers Bangalore
2008–2018
167
78
84
1
1
3
48.17
0

Kolkata Knight Riders
2008–2018
162
85
75
0
2
0
53.08
2

Kings XI Punjab
2008–2018
162
74
86
2
0
0
46.29
0

Delhi Daredevils
2008–2018
161
67
91
0
1
2
42.45
0

Chennai Super Kings
2008–2018
148
90
56
0
1
1
61.56
3

Rajasthan Royals
2008–2018
132
68
60
2
1
1
53.05
1

Sunrisers Hyderabad
2013–2018
93
51
41
1
0
0
55.37
1

Deccan Chargers
2008–2012
75
29
46
0
0
0
38.66
1

Pune Warriors India
2011–2013
46
12
33
0
0
1
26.66
0

Rising Pune Supergiants
2016–2017
30
15
15
0
0
0
50.00
0

Gujarat Lions
2016–2017
30
13
16
0
1
0
45.00
0

Kochi Tuskers Kerala
2011–2011
14
6
8
0
0
0
42.85
0

text: Note:

text:
Defunct Teams
Tie+W and Tie+L indicates matches tied and then won or lost by "Super Over"
The result percentage excludes no results and counts ties (irrespective of a tiebreaker) as half a win
The total matches does not include matches played for Champions League T20

tag: ul

text: Last updated: 28 May 2018

text: Highest totals

text:
Score
Team
Opponent
Season

7002264166666666669♠263/5 [a]
Royal Challengers Bangalore
Pune Warriors India
2013

248/3
Royal Challengers Bangalore
Gujarat Lions
2016

7002247166666666670♠246/5
Chennai Super Kings
Rajasthan Royals
2010

7002245166666666670♠245/6
Kolkata Knight Riders
Kings XI Punjab
2018

7002241166666666670♠240/5
Chennai Super Kings
Kings XI Punjab
2008

7002235166666666670♠235/1
Royal Challengers Bangalore
Mumbai Indians
2015

text: Last updated: 12 May 2018

text: Lowest totals

text:
Score
Team
Opponent
Season

7001680909090909090♠49
Royal Challengers Bangalore
Kolkata Knight Riders
2017

7001680909090909090♠58
Rajasthan Royals
Royal Challengers Bangalore
2009

7001680909090909090♠66
Delhi Daredevils
Mumbai Indians
2017

7001680909090909090♠67
Delhi Daredevils
Kings XI Punjab
2017

7001680909090909090♠67
Kolkata Knight Riders
Mumbai Indians
2008

text: Last updated: 21 May 2017

text: Highest successful run chases

text:
Score
Team
Opponent
Season

217/7
Rajasthan Royals
Deccan Chargers
2008

214/3
Delhi Daredevils
Gujarat Lions
2017

211/4
Kings XI Punjab
Sunrisers Hyderabad
2014

208/5
Chennai Super Kings
Royal Challengers Bangalore
2012

207/5
Chennai Super Kings
Royal Challengers Bangalore
2018

text: Last updated: 21 May 2018

text: Lowest scores defended

text:
Score
Team
Opponent
Opponent score
Season

116/9
Chennai Super Kings
Kings XI Punjab
92/8
2009

118
Sunrisers Hyderabad
Mumbai Indians
87
2018

119/8
Kings XI Punjab
Mumbai Indians
116/7
2009

Royal Challengers Bangalore
Pune Warriors India
108/10
2013

120/9
Mumbai Indians
Pune Warriors India
119/6
2012

126/8
Royal Challengers Bangalore
Chennai Super Kings
112/8
2008

Sunrisers Hyderabad
Pune Warriors India
104/10
2013

text: Largest victories (by runs)

text:
Score
Team
Opponent
Season

146
Mumbai Indians
Delhi Daredevils
2017

144
Royal Challengers Bangalore
Gujarat Lions
2016

140
Kolkata Knight Riders
Royal Challengers Bangalore
2008

138
Royal Challengers Bangalore
Kings XI Punjab
2015

130
Royal Challengers Bangalore
Pune Warriors
2013

text: Last updated: 21 May 2017

text: Batting records

text: Most runs

text:
Batsman
Inns
Runs
Span

 Suresh Raina (CSK,GL)
172
4985
2008–2018

 Virat Kohli (RCB)
155
4948
2008–2018

 Sharma, RohitRohit Sharma (DC, MI)
168
4493
2008–2018

 Gambhir, GautamGautam Gambhir (DD, KKR)
152
4217
2008–2018

 Robin Uthappa (KKR, MI, PWI, RCB)
159
4129
2008–2018

text: Last updated: 28 May 2018

text: Highest individual score

text:
Batsman
Runs
Balls
Opp
Season

 Gayle, ChrisChris Gayle (RCB)
7002175000000000000♠175*
66
PWI
2013

 McCullum, BrendonBrendon McCullum (KKR)
7002158000000000000♠158*
73
RCB
2008

 Villiers, AB deAB de Villiers (RCB)
7002133000000000000♠133*
59
MI
2015

 Villiers, AB deAB de Villiers (RCB)
7002129000000000000♠129*
52
GL
2016

 Chris Gayle (RCB)
7002128000000000000♠128*
62
DD
2012

text: Last updated: 21 May 2017

text: Most sixes (overall)

text:
Batsman
Inn
6's
Span

 Chris Gayle (KKR, RCB, KXIP)
111
292
2009–2018

 AB de Villiers (DD, RCB)
129
187
2008-2018

 MS Dhoni (CSK, RPS)
158
186
2008–2018

 Suresh Raina (CSK, GL)
172
185
2008–2018

 Rohit Sharma (DC, MI)
168
184
2008–2018

text: Last updated: 28 May 2018

text: Most sixes (innings)

text:
Batsman
6's
Opponent
Season

 Chris Gayle (RCB)
17
PWI
2013

 Brendon McCullum (KKR)
13
RCB
2008

 Chris Gayle (RCB)
DD
2012

 Chris Gayle (RCB)
12
KXIP
2015

 AB de Villiers (RCB)
GL
2016

text: Last updated: 21 May 2017

text: Fastest centuries

text:
Batsman
Balls
Opp
Season

 Chris Gayle (RCB)
30
PWI
2013

 Yusuf Pathan (RR)
37
MI
2010

 David Miller (KXIP)
38
RCB
2013

 Adam Gilchrist (DC)
42
MI
2008

 AB de Villiers (RCB)
43
GL
2016

text: Last updated: 21 May 2017

text: Fastest fifties

text:
Batsman
Balls
Opp
Season

 K. L. Rahul (KXIP)
14
DD
2018

 Sunil Narine (KKR)
15
RCB
2017

 Yusuf Pathan (KKR)
SRH
2014

 Suresh Raina (CSK)
16
KXIP
2014

 Sunil Narine (KKR)
17
RCB
2018

 Ishan Kishan (MI)
KKR
2018

 Kieron Pollard (MI)
KKR
2016

 Chris Morris (DD)
GL
2016

 Chris Gayle (RCB)
PWI
2013

 Adam Gilchrist (DC)
DD
2009

 Jos Buttler (RR)
18
DD
2018

text: Last updated: 8 April 2018

text: Best strike rate

text:
Batsman
SR
Span

 Russell, AndreAndre Russell (DD, KKR)
177.29
2012–2018

 Sunil Narine (KKR)
168.81
2012–2018

 Chris Morris (CSK, DD, RR)
166.66
2013–2018

 Rishabh Pant (DD)
162.71
2016–2018

 Maxwell, GlennGlenn Maxwell (DD, KXIP, MI)
161.13
2012–2018

text: Minimum balls faced – 125

text: Last updated: 28 May 2017

text: Bowling records

text: Most wickets

text:
Bowler
Inn
Wkts
Span

 Malinga, LasithLasith Malinga (MI)
110
154
2009–2017

 Mishra, AmitAmit Mishra (DC, DD, SRH)
136
146
2008–2018

 Piyush Chawla (KXIP, KKR)
143
140
2008–2018

 Dwayne Bravo (CSK, GL, MI)
119
136
2008–2018

 Harbhajan Singh (MI,CSK)
146
134
2008–2018

text: Last updated: 28 May 2018

text: Best bowling figures in an innings

text:
Player
Ovr
BBI
Opp
Season

 Sohail TanvirSohail Tanvir (RR)
4.0
7000706666666666670♠6-14
CSK
2008

 Zampa, AdamAdam Zampa (RPS)
4.0
7000616666666666670♠6-19
SRH
2016

 Kumble, AnilAnil Kumble (RCB)
3.1
7000616666666666670♠5-5
RR
2009

 Sharma, IshantIshant Sharma (DC)
3.0
7000607692307692310♠5-12
KTK
2011

 Malinga, LasithLasith Malinga (MI)
3.4
7000607142857142860♠5-13
DD
2011

text: Last updated: 21 May 2017

text: Best bowling averages

text:
Player
Mat
Average
Span

 Andrew Tye (KXIP,GL)
20
16.36
2017–2018

 Doug Bollinger (CSK)
27
18.72
2010–2012

 Mascarenhas, DimitriDimitri Mascarenhas (KXIP, RR)
13
18.73
2008–2013

 Malinga, LasithLasith Malinga (MI)
110
19.01
2009–2017

 Farveez Maharoof (DC)
20
19.25
2008–2010

text: Last updated: 28 May 2018

text: Best economy rates

text:
Player
Mat
Econ
Span

 Narine, SunilSunil Narine (KKR)
98
6.54
2012–2018

 Shaun Pollock (MI)
13
6.54
2008–2008

 Kumble, AnilAnil Kumble (RCB)
42
6.57
2009–2010

 Glenn Mcgrath (DD)
14
6.61
2008–2008

 Muttiah Muralitharan (CSK,KTK,RCB)
66
6.67
2008–2014

text: Last updated: 28 May 2018

text: Most runs conceded in an innings

text:
Bowler
Overs
Wkts
Runs
Opp
Season

 Basil Thampi (SRH)
4.0
0
70
RCB
2018

 Ishant Sharma (SRH)
4.0
0
66
CSK
2013

 Umesh Yadav (DD)
4.0
0
65
RCB
2013

 Sandeep Sharma (KXIP)
4.0
1
65
SRH
2014

 Varun Aaron (DD)
4.0
2
63
CSK
2012

text: Last updated: 28 May 2018

text: Most dot balls bowled

text:
Player
Inns
Dot Balls

 Harbhajan Singh
145
1128

 Praveen Kumar
119
1075

 Lasith Malinga
110
1060

 Amit Mishra
136
1027

 Piyush Chawla
143
1020

text: Last updated: 28 May 2018

text: Most maiden overs bowled

text:
Player
Inns
Maidens

 Praveen Kumar
119
14

 Irfan Pathan
101
10

 Lasith Malinga
110
8

 Sandeep Sharma
68
8

 Dhawal Kulkarni
79
7

 Dale Steyn
90
7

text: Last updated: 28 May 2018

text: List of hat-tricks

text:
No.
Bowler
Opp
Season

1
 Lakshmipathy Balaji (CSK)
KXIP
2008

2
 Amit Mishra (DD)
DC
2008

3
 Makhaya Ntini (CSK)
KKR
2008

4
 Yuvraj Singh (KXIP)
RCB
2009

5
 Rohit Sharma (DC)
MI
2009

6
 Yuvraj Singh (KXIP)
DC
2009

7
 Praveen Kumar (RCB)
RR
2010

8
 Amit Mishra (DC)
KXIP
2011

9
 Ajit Chandila (RR)
PWI
2012

10
 Sunil Narine (KKR)
KXIP
2013

11
 Amit Mishra (SRH)
PWI
2013

12
 Pravin Tambe (RR)
KKR
2014

13
 Shane Watson (RR)
SRH
2014

14
 Axar Patel (KXIP)
GL
2016

15
 Samuel Badree (RCB)
MI
2017

16
 Andrew Tye (GL)
RPS
2017

17
 Jaydev Unadkat (RPS)
SRH
2017

text: Hat-tricks in IPL[1]

text: Last updated: 21 May 2017

text: Wicketkeeping and fielding records

text: Most dismissals

text:
Wicket Keeper
Dis
Ct
St
Span

 Karthik, DineshDinesh Karthik (DD, KXIP, MI, RCB,KKR,GL)
124
94
30
2008–2018

 MS Dhoni (CSK, RPS)
116
83
33
2008–2018

 Uthappa, RobinRobin Uthappa (KKR, MI, PWI, RCB)
90
58
32
2008–2018

 Naman Ojha (DD, RR, SRH)
75
65
10
2008–2018

 Patel, ParthivParthiv Patel (CSK, DC, KTK, MI, RCB, SRH)
74
60
14
2008–2018

text: Last updated: 28 May 2018

text: Most catches (fielder)

text:
Player
Ct
Span

 Suresh Raina (CSK, GL)
95
2008–2018

 Rohit Sharma (DC, MI)
79
2008–2018

 AB de Villiers (DD, RCB)
78
2008–2018

 Kieron Pollard (MI)
74
2010–2018

 Dwayne Bravo (CSK, MI,Gujarat Lions)
69
2008–2018

text: Last updated: 28 May 2018

text: Miscellaneous records

text:
Records
Player /
Team
Stats
Season /
Span

Team

Most wins[2]
Mumbai Indians
97
(2008–2018)

Most defeats[2]
Delhi Daredevils
91
(2008–2018)

Highest win%[2]
Chennai Super Kings
61.56
(2008–2018)

Largest victory (runs)[3]
Mumbai Indians v Delhi Daredevils
146
2017

Most consecutive wins
(season)[4]
Kolkata Knight Riders
9
2014

Most consecutive wins
(overall)
Kolkata Knight Riders
10
(2014–2015)

Most consecutive defeats
(season)[5]
Delhi Daredevils
Pune Warriors
9
2014
2012

Most consecutive defeats
(overall)
Delhi Daredevils
Pune Warriors
11
(2014–2015)
(2012–2013)

Batting

Most 100s[6]
 Chris Gayle (KKR, RCB, KXIP)
6
(2008–2018)

Most 50s[7]
 David Warner (DD, SRH)
36
(2009–2017)

Highest Partnership[8]
 Virat Kohli (RCB)
 AB de Villiers (RCB)
229
2016

Most ducks[9]
 Harbhajan Singh (MI)
13
(2008–2018)

Bowling

Most 4 wicket hauls[10][11]
 Sunil Narine (KKR)
6
(2012–2018)

Most 5 wicket hauls[12]
 James Faulkner (KXIP, PWI, RR )
2
(2011–2017)

Most hat-tricks[1]
 Amit Mishra (DC, DD, SRH)
3
(2008–2018)

Other Miscellaneous

Most matches[13]
 Suresh Raina (CSK, GL)
176
(2008–2018)

Most matches as captain[14]
 MS Dhoni (CSK, RPS)
159
(2008–2018)

Most man of the matches[15]
 Chris Gayle (KKR, RCB, KXIP)
20
(2008–2018)

Most matches as umpire[16]
 Sundaram Ravi
97
(2009–2018)

text: ☢ Last updated: 28 May 2018

text: Awards