document_title: Neuromuscular junction

question_text: a nerve impulse triggers the release of what chemical at a neuromuscular junction

text: Neuromuscular junction

text: Structure and function of the neuromuscular junction[edit]

text: The neuromuscular junction differs from chemical synapses between neurons. Presynaptic motor axons stop 30 nanometers from the sarcolemma, the cell membrane of a muscle cell. This 30-nanometer space forms the synaptic cleft through which signalling molecules are released. The sarcolemma has invaginations called postjunctional folds, which increase the surface area of the membrane exposed to the synaptic cleft.[2] These postjunctional folds form what is referred to as the motor endplate, which possess nicotinic acetylcholine receptors (nAChRs) at a density of 10,000 receptors/micrometer2 in skeletal muscle.[3] The presynaptic axons form bulges called terminal boutons (or presynaptic terminals) that project into the postjunctional folds of the sarcolemma. The presynaptic terminals have active zones that contain vesicles, also called quanta, full of acetylcholine molecules. These vesicles can fuse with the presynaptic membrane and release ACh molecules into the synaptic cleft via exocytosis after depolarization.[2] AChRs are localized opposite the presynaptic terminals by protein scaffolds at the postjunctional folds of the sarcolemma. Dystrophin, a structural protein, connects the sarcomere, sarcolemma, and extracellular matrix components. Rapsyn is another protein that docks AChRs and structural proteins to the cytoskeleton. Also present is the receptor tyrosine kinase protein MuSK, a signaling protein involved in the development of the neuromuscular junction, which is also held in place by rapsyn.[2]

text: Mechanism of action[edit]

text: The neuromuscular junction is where a neuron activates a muscle to contract. Upon the arrival of an action potential at the presynaptic neuron terminal, voltage-dependent calcium channels open and Ca2+ ions flow from the extracellular fluid into the presynaptic neuron's cytosol. This influx of Ca2+ causes neurotransmitter-containing vesicles to dock and fuse to the presynaptic neuron's cell membrane through SNARE proteins. Fusion of the vesicular membrane with the presynaptic cell membrane results in the emptying of the vesicle's contents (acetylcholine) into the synaptic cleft, a process known as exocytosis. Acetylcholine diffuses into the synaptic cleft and can bind to the nicotinic acetylcholine receptors on the motor endplate.

text: Acetylcholine receptors at the neuromuscular junction[edit]

text:
Ion channel linked receptor
Ions
Ligand (such as acetylcholine)

text: Acetylcholine is a neurotransmitter synthesized from dietary choline and acetyl-CoA (ACoA), and is involved in the stimulation of muscle tissue in vertebrates as well as in some invertebrate animals. In vertebrate animals, the acetylcholine receptor subtype that is found at the neuromuscular junction of skeletal muscles is the nicotinic acetylcholine receptor (nAChR), which is a ligand-gated ion channel. Each subunit of this receptor has a characteristic “cys-loop,” which is composed of a cysteine residue followed by 13 amino acid residues and another cysteine residue. The two cysteine residues form a disulfide linkage which results in the “cys-loop” receptor that is capable of binding acetylcholine and other ligands. These cys-loop receptors are found only in eukaryotes, but prokaryotes possess ACh receptors with similar properties.[3] Not all species use a cholinergic neuromuscular junction; e.g. crayfish and fruit flies have a glutamatergic neuromuscular junction.[2]

text: AChRs at the skeletal neuromuscular junction form heteropentamers composed of two α, one β, one ɛ, and one δ subunits.[4] When a single ACh ligand binds to one of the α subunits of the ACh receptor it induces a conformational change at the interface with the second AChR α subunit. This conformational change results in the increased affinity of the second α subunit for a second ACh ligand. AChRs therefore exhibit a sigmoidal dissociation curve due to this cooperative binding .[3] The presence of the inactive, intermediate receptor structure with a single-bound ligand keeps ACh in the synapse that might otherwise be lost by cholinesterase hydrolysis or diffusion. The persistence of these ACh ligands in the synapse can cause a prolonged post-synaptic response.[5]

text: Development of the neuromuscular junction[edit]

text: The development of the neuromuscular junction requires signaling from both the motor neuron's terminal and the muscle cell's central region, During development, muscle cells produce acetylcholine receptors (AChRs) and express them in the central regions in a process called prepatterning. Agrin, a heparin proteoglycan, and MuSK kinase are thought to help stabilize the accumulation of AChR in the central regions of the myocyte. MuSK is a receptor tyrosine kinase — meaning that it induces cellular signaling by binding phosphate molecules to self regions like tyrosines, and to other targets in the cytoplasm.[6] Upon activation by its ligand agrin, MuSK signals via two proteins called "Dok-7" and "rapsyn", to induce "clustering" of acetylcholine receptors.[7] ACh release by developing motor neurons produces postsynaptic potentials in the muscle cell that positively reinforces the localization and stabilization of the developing neuromuscular junction.[8]

text: These findings were demonstrated in part by mouse "knockout" studies. In mice which are deficient for either agrin or MuSK, the neuromuscular junction does not form. Further, mice deficient in Dok-7 did not form either acetylcholine receptor clusters or neuromuscular synapses.[9]

text: The development of neuromuscular junctions is mostly studied in model organisms, such as rodents. In addition, in 2015 an all-human neuromuscular junction has been created in vitro using human embryonic stem cells and somatic muscle stem cells.[10] In this model presynaptic motor neurons are activated by optogenetics and in response synaptically connected muscle fibers twitch upon light stimulation.

text: Research methods[edit]

text: José del Castillo and Bernard Katz used ionophoresis to determine the location and density of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. With this technique, a microelectrode was placed inside the motor endplate of the muscle fiber, and a micropipette filled with acetylcholine (ACh) is placed directly in front of the endplate in the synaptic cleft. A positive voltage was applied to the tip of the micropipette, which caused a burst of positively charged ACh molecules to be released from the pipette. These ligands flowed into the space representing the synaptic cleft and bound to AChRs. The intracellular microelectrode monitored the amplitude of the depolarization of the motor endplate in response to ACh binding to nicotinic (ionotropic) receptors. Katz and del Castillo showed that the amplitude of the depolarization (excitatory postsynaptic potential) depended on the proximity of the micropipette releasing the ACh ions to the endplate. The farther the micropipette was from the motor endplate, the smaller the depolarization was in the muscle fiber. This allowed the researchers to determine that the nicotinic receptors were localized to the motor endplate in high density.[2][3]

text: Toxins are also used to determine the location of acetylcholine receptors at the neuromuscular junction. α-Bungarotoxin is a toxin found in the snake species Bungarus multicinctus that acts as an ACh antagonist and binds to AChRs irreversibly. By coupling assayable enzymes such as horseradish peroxidase (HRP) or fluorescent proteins such as green fluorescent protein (GFP) to the α-bungarotoxin, AChRs can be visualized and quantified.[2]

text: Toxins that affect the neuromuscular junction[edit]

text: Nerve gases[edit]

text: Nerve gases and liquor damage this area.

text: Botulinum toxin[edit]

text: Botulinum toxin (aka botulinum neurotoxin, BoNT, and sold under the trade name Botox) inhibits the release of acetylcholine at the neuromuscular junction by interfering with SNARE proteins.[2] This toxin crosses into the nerve terminal through the process of endocytosis and subsequently interferes with SNARE proteins, which are necessary for ACh release. By doing so, it induces a transient flaccid paralysis and chemical denervation localized to the striated muscle that it has affected. The inhibition of the ACh release does not set in until approximately two weeks after the injection is made. Three months after the inhibition occurs, neuronal activity begins to regain partial function, and six months, complete neuronal function is regained.[11]

text: Tetanus toxin[edit]

text: Tetanus toxin, also known as tetanospasmin is a potent neurotoxin produced by Clostridium tetani and causes the disease state, tetanus. The LD50 of this toxin has been measured to be approximately 1 ng/kg, making it second only to Botulinum toxin D as the deadliest toxin in the world. It functions very similarly to botunlinum neurotoxin (BoNT) by attaching and endocytosing into the presynaptic nerve terminal and interfering with SNARE protein complexes. It differs from BoNT in a few ways, most apparently in its end state, wherein tetanospasmin demonstrates a rigid / spastic paralysis as opposed to the flaccid paralysis demonstrated with BoNT.

text: Latrotoxin[edit]

text: Latrotoxin (α-Latrotoxin) found in venom of widow spiders also affects the neuromuscular junction by causing the release of acetylcholine from the presynaptic cell. Mechanisms of action include binding to receptors on the presynaptic cell activating the IP3/DAG pathway and release of calcium from intracellular stores and pore formation resulting in influx of calcium ions directly. Either mechanism causes increased calcium in presynaptic cell, which then leads to release of synaptic vesicles of acetylcholine. Latrotoxin causes pain, muscle contraction and if untreated potentially paralysis and death.

text: Snake venom[edit]

text: Snake venoms act as toxins at the neuromuscular junction and can induce weakness and paralysis. Venoms can act as both presynaptic and postsynaptic neurotoxins.[12]

text: Presynaptic neurotoxins, commonly known as β-neurotoxins, affect the presynaptic regions of the neuromuscular junction. The majority of these neurotoxins act by inhibiting the release of neurotransmitters, such as acetylcholine, into the synapse between neurons. However, some of these toxins have also been known to enhance neurotransmitter release. Those that inhibit neurotransmitter release create a neuromuscular blockade that prevents signaling molecules from reaching their postsynaptic target receptors. In doing so, the victim of these snake bite suffer from profound weakness. Such neurotoxins do not respond well to anti-venoms. After one hour of inoculation of these toxins, including notexin and taipoxin, many of the affected nerve terminals show signs of irreversible physical damage, leaving them devoid of any synaptic vesicles.[12]

text: Postsynaptic neurotoxins, otherwise known as α-neurotoxins, act oppositely to the presynaptic neurotoxins by binding to the postsynaptic acetylcholine receptors. This prevents interaction between the acetylcholine released by the presynaptic terminal and the receptors on the postsynaptic cell. In effect, the opening of sodium channels associated with these acetylcholine receptors is prohibited, resulting in a neuromuscular blockade, similar to the effects seen due to presynaptic neurotoxins. This causes paralysis in the muscles involved in the affected junctions. Unlike presynaptic neurotoxins, postsynaptic toxins are more easily affected by anti-venoms, which accelerate the dissociation of the toxin from the receptors, ultimately causing a reversal of paralysis. These neurotoxins experimentally and qualitatively aid in the study of acetylcholine receptor density and turnover, as well as in studies observing the direction of antibodies toward the affected acetylcholine receptors in patients diagnosed with myasthenia gravis.[12]

text: Diseases[edit]

text: Any disorder that compromises the synaptic transmission between a motor neuron and a muscle cell is categorized under the umbrella term of neuromuscular diseases. These disorders can be inherited or acquired and can vary in their severity and mortality. In general, most of these disorders tend to be caused by mutations or autoimmune disorders. Autoimmune disorders, in the case of neuromuscular diseases, tend to be humoral mediated, B cell mediated, and result in an antibody improperly created against a motor neuron or muscle fiber protein that interferes with synaptic transmission or signaling.

text: Autoimmune[edit]

text: Myasthenia gravis[edit]

text: Myasthenia gravis is an autoimmune disorder where the body makes antibodies against either the acetylcholine receptor (AchR) (in 80% of cases), or against postsynaptic muscle-specific kinase (MuSK) (0–10% of cases). In seronegative myasthenia gravis low density lipoprotein receptor-related protein 4 is targeted by IgG1, which acts as a competitive inhibitor of its ligand, preventing the ligand from binding its receptor. It is not known if seronegative myasthenia gravis will respond to standard therapies.[13]

text: Neonatal MG[edit]

text: Neonatal MG is an autoimmune disorder that affects 1 in 8 children born to mothers who have been diagnosed with Myasthenia gravis (MG). MG can be transferred from the mother to the fetus by the movement of AChR antibodies through the placenta. Signs of this disease at birth include weakness, which responds to anticholinesterase medications, as well as fetal akinesia, or the lack of fetal movement. This form of the disease is transient, lasting for about three months. However, in some cases, neonatal MG can lead to other health effects, such as arthrogryposis and even fetal death. These conditions are thought to be initiated when maternal AChR antibodies are directed to the fetal AChR and can last until the 33rd week of gestation, when the γ subunit of AChR is replaced by the ε subunit.[14]

text: Lambert-Eaton myasthenic syndrome[edit]

text: Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder that affects the presynaptic portion of the neuromuscular junction. This rare disease can be marked by a unique triad of symptoms: proximal muscle weakness, autonomic dysfunction, and areflexia.[15] Proximal muscle weakness is a product of pathogenic autoantibodies directed against P/Q-type voltage-gated calcium channels, which in turn leads to a reduction of acetylcholine release from motor nerve terminals on the presynaptic cell. Examples of autonomic dysfunction caused by LEMS include erectile dysfunction in men, constipation, and, most commonly, dry mouth. Less common dysfunctions include dry eyes and altered perspiration. Areflexia is a condition in which tendon reflexes are reduced and it may subside temporarily after a period of exercise.[16]

text: 50–60% of the patients that are diagnosed with LEMS also have present an associated tumor, which is typically small-cell lung carcinoma (SCLC). This type of tumor also expresses voltage-gated calcium channels.[16] Oftentimes, LEMS also occurs alongside myasthenia gravis.[15]

text: Treatment for LEMS consists of using 3,4-diaminopyridine as a first measure, which serves to increase the compound muscle action potential as well as muscle strength by lengthening the time that voltage-gated calcium channels remain open after blocking voltage-gated potassium channels. In the US, treatment with 3,4-diaminopyridine for eligible LEMS patients is available at no cost under an expanded access program.[17][18] Further treatment includes the use of prednisone and azathioprine in the event that 3,4-diaminopyridine does not aid in treatment.[16]

text: Neuromyotonia[edit]

text: Neuromyotonia (NMT), otherwise known as Isaac’s syndrome, is unlike many other diseases present at the neuromuscular junction. Rather than causing muscle weakness, NMT leads to the hyperexcitation of motor nerves. NMT causes this hyperexcitation by producing longer depolarizations by down-regulating voltage-gated potassium channels, which causes greater neurotransmitter release and repetitive firing. This increase in rate of firing leads to more active transmission and as a result, greater muscular activity in the affected individual. NMT is also believed to be of autoimmune origin due to its associations with autoimmune symptoms in the individual affected.[14]

text: Genetic[edit]

text: Congenital myasthenic syndromes[edit]

text: Congenital myasthenic syndromes (CMS) are very similar to both MG and LEMS in their functions, but the primary difference between CMS and those diseases is that CMS is of genetic origins. Specifically, these syndromes are diseases incurred due to mutations, typically recessive, in 1 of at least 10 genes that affect presynaptic, synaptic, and postsynaptic proteins in the neuromuscular junction. Such mutations usually arise in the ε-subunit of AChR,[14] thereby affecting the kinetics and expression of the receptor itself. Single nucleotide substitutions or deletions may cause loss of function in the subunit. Other mutations, such as those affecting acetylcholinesterase and acetyltransferase, can also cause the expression of CMS, with the latter being associated specifically with episodic apnea.[19] These syndromes can present themselves at different times within the life of an individual. They may arise during the fetal phase, causing fetal akinesia, or the perinatal period, during which certain conditions, such as arthrogryposis, ptosis, hypotonia, ophthalmoplegia, and feeding or breathing difficulties, may be observed. They could also activate during adolescence or adult years, causing the individual to develop slow-channel syndrome.[14]

text: Treatment for particular subtypes of CMS (postsynaptic fast-channel CMS)[20][21] is similar to treatment for other neuromuscular disorders. 3,4-Diaminopyridine, the first-line treatment for LEMS, is under development as an orphan drug for CMS[22] in the US, and available to eligible patients under an expanded access program at no cost.[17][18]

text: Bulbospinal muscular atrophy[edit]

text: Bulbospinal muscular atrophy, also known as Kennedy’s disease, is a rare recessive trinucleotide, polyglutamine disorder that is linked to the X chromosome. Because of its linkage to the X chromosome, it is typically transmitted through females. However, Kennedy’s disease is only present in adult males and the onset of the disease is typically later in life. This disease is specifically caused by the expansion of a CAG-tandem repeat in exon 1 found on the androgen-receptor (AR) gene on chromosome Xq11-12. Poly-Q-expanded AR accumulates in the nuclei of cells, where it begins to fragment. After fragmentation, degradation of the cell begins, leading to a loss of both motor neurons and dorsal root ganglia.[23]

text: Symptoms of Kennedy’s disease include weakness and wasting of the facial bulbar and extremity muscles, as well as sensory and endocrinological disturbances, such as gynecomastia and reduced fertility. Other symptoms include elevated testosterone and other sexual hormone levels, development of hyper-CK-emia, abnormal conduction through motor and sensory nerves, and neuropathic or in rare cases myopathic alterations on biopsies of muscle cells.[23]

text: Duchenne muscular dystrophy[edit]

text: Duchenne muscular dystrophy is an X-linked genetic disorder that results in the absence of the structural protein dystrophin at the neuromuscular junction. It affects 1 in 3,600–6,000 males and frequently causes death by the age of 30. The absence of dystrophin causes muscle degeneration, and patients present with the following symptoms: abnormal gait, hypertrophy in the calf muscles, and elevated creatine kinase. If left untreated, patients may suffer from respiratory distress, which can lead to death.[24]


document_title: India International Exchange

question_text: india's first international stock exchange has been launched recently in which city

question_tokens: india 's first international stock exchange has been launched recently in which city

root

text: India International Exchange

text:
India International Exchange

Type
Stock Exchange

Location
Gujarat International Finance Tec-City, Gandhinagar, Gujarat, India

Founded
2017

Owner
subsidiary of Bombay Stock Exchange

Key people
Mr. V. Balasubramaniam (Chief Executive Officer and Managing Director)

Currency
Indian rupee (INR/₹)

Website
www.indiainx.com

tag: table

text: The India International Exchange (INX) is India's first international stock exchange, opened in 2017.[1][2] It is located at the International Financial Services Centre (IFSC), GIFT City in Gujarat. It is a wholly owned subsidiary of the Bombay Stock Exchange (BSE).[3] The INX will be initially headed by V. Balasubramanian with other staff from the BSE.[3]

tag: p

text: It was inaugurated on 9 January 2017 by Indian prime minister Narendra Modi, the trading operations were scheduled to begin on 16 January 2017. It was claimed to be fastest in the world and aimed to operate for 22 hours a day .[1]


document_title: Super Bowl XXXIX

question_text: who won the superbowl in 2004 and 2005

question_tokens: who won the superbowl in 2004 and 2005

text: Super Bowl XXXIX

text: Background[edit]

text: NFL owners voted to award Super Bowl XXXIX to Jacksonville during their November 1, 2000 meeting held in Atlanta.[8]

text: Patriots seek to become a dynasty[edit]

text: New England finished the regular season with a record of 14–2, bested only by the Steelers' 15–1 mark, and ranking 7th in yards gained (5,773) and fourth in points scored (437).

text: The Patriots' major acquisition prior to the season was veteran running back Corey Dillon, who joined the team after playing 7 seasons with the Cincinnati Bengals.[9] In his first 6 seasons in the league, Dillon averaged over 1,250 rushing yards per year, including setting a single-game rushing record (278 yards, but has since been broken) against the Denver Broncos on October 22, 2000. In 2003, however, injuries, conflicts with the Bengals' management and coaching staff, and other off-field problems limited him to just 541 yards during the season. By the end of the 2003 season, Dillon had lost his starting job to running back Rudi Johnson, and thus demanded to be traded. [10] Although many observers questioned how effective the 30-year-old Dillon would be after recovering from his injuries as well as his ability to function in a team environment, the Patriots decided to sign the running back in exchange for a second-round draft pick.[10]

text: Dillon became a significant offensive weapon for the 2004 Patriots, recording 1,635 rushing yards (franchise record) and 12 touchdowns, both career highs, and was named to the Pro Bowl for the fourth time in his career.[10] He also caught 15 passes for 103 yards and another touchdown.[10] His contributions helped lead the team to break the NFL record for the most consecutive regular season victories (18), the record for the most consecutive overall victories (21) and earned the second best regular season record during the year at 14–2.[10] The team's only losses during the year were to the Pittsburgh Steelers, who ended up with the league's best regular season record at 15–1, and a 29–28 loss to the Miami Dolphins on ABC's Monday Night Football.[10]

text: Another weapon in the Patriots' offensive backfield was running back Kevin Faulk, who rushed for 255 yards, recorded 26 receptions for 248 yards, returned 20 punts for 113 yards, returned 4 kickoffs for 73 yards, and scored 3 total touchdowns.[10] Fullback Patrick Pass also emerged as a big contributor, rushing for 141 yards, catching 28 passes for 215 yards, and gaining another 115 yards on kickoff returns.[10]

text: Pro Bowl quarterback Tom Brady remained at the helm of the Patriots offense, completing 288 out of 474 (60.8 percent) of his passes for 3,692 yards, 28 touchdowns, and 14 interceptions.[10] Although wide receiver Deion Branch, New England's major deep threat, missed most of the season because of injuries, he did record 35 receptions for 454 yards and 4 touchdowns. Wide receiver David Givens ended up being the team's leading receiver with 56 catches for 874 yards and 3 touchdowns.[10] Wide receiver David Patten also contributed with 44 receptions for 800 yards and 7 touchdowns, and tight end Daniel Graham had 30 receptions for 364 yards and 7 touchdowns.[10] On special teams, pro bowl kicker Adam Vinatieri had the best season of his career, leading the NFL in field goals made (31), field goal percentage (93.9) and scoring (141 points)

text: On defense, the Patriots were plagued by injuries, especially in their secondary. Defensive backs Tyrone Poole and Ty Law suffered season-ending injuries, while safety Eugene Wilson, who led the team with 4 interceptions, missed several games.[10] In order to compensate for the losses, the following players were promoted to starters:

text:
Rookie cornerback Randall Gay, who did not play at all in the first 3 games of the season, and did not start until the 6th week.[10]
Cornerback Asante Samuel, who normally only played in dime formations.[10]
Safety Earthwind Moreland, who came off of the team's practice squad and had only played in three games in his entire 5-year NFL career.[10]
Veteran wide receiver Troy Brown.[10] Head Coach Bill Belichick used Brown in the secondary during training camp, gave him playing time there during the preseason and saw Brown did very well.

tag: ul

text: With their patchwork secondary, the Patriots ranked just 17th in passing yards allowed (3,400) and 22nd in completions allowed (315).[10] However, they did rank 7th in interceptions (20) and 10th in fewest passing touchdowns allowed (18).[10] Most importantly, New England continued to win despite the injuries. Brown actually turned out to be very effective playing as a defensive back, ranking second on the team with 3 interceptions. Safety Rodney Harrison was also an impact player, leading the team with 138 tackles while also recording 3 sacks and 2 interceptions.[10]

text: Up front, the Patriots' defensive line was anchored by Pro Bowler Richard Seymour, who recorded 5 sacks and 1 fumble recovery.[10] New England also still had their trio of impact veteran linebackers: Pro Bowler Tedy Bruschi (122 tackles, 3.5 sacks, 3 interceptions, and 70 return yards), Willie McGinest (9.5 sacks, 1 fumble recovery, and 1 interception), and Mike Vrabel (71 tackles and 5.5 sacks), along with Ted Johnson.[10] Vrabel also frequently played at the tight end position during offensive plays near the opponent's goal line, recording 2 touchdown receptions. [10]

text: Eagles return to the Super Bowl[edit]

text: The Eagles gained the 2004 NFC Super Bowl berth after 3 consecutive defeats in the NFC Championship Game to the St. Louis Rams, Tampa Bay Buccaneers (who won Super Bowl XXXVII that year), and Carolina Panthers, respectively. The Eagles hired Andy Reid as their head coach in 1999 following two straight losing seasons.[10] That same year, they used their first-round pick in the NFL draft (the second overall) to select quarterback Donovan McNabb.[10] Although they finished the 1999 regular season with a 5–11 record, they became a playoff team in 2000, with McNabb throwing for 3,365 yards and 21 touchdowns while also rushing for 629 yards and another 6 touchdowns.[10]

text: The Eagles achieved the best regular season record in the conference during the combined 2001, 2002, and 2003 seasons with a total of 35 wins out of 48 games, but lost the NFC Championship Game in each of those 3 years. Prior to the 2004 season, the Eagles traded for wide receiver Terrell Owens to be the impact player to help get them to the Super Bowl.[10]

text: Owens joined the team after 8 seasons with the San Francisco 49ers. [10] He was considered one of the top receivers in the league, but he was also widely considered a troublemaker because of controversial touchdown celebrations and his tendency to berate his teammates during media interviews. Nevertheless, Owens became the Eagles' deep-ball threat, finishing the season with 77 receptions for 1,200 yards and 14 touchdowns.[10]

text: McNabb had the best season of his career in 2004, completing 300 out of 469 (64 percent) passes for 3,875 yards, 31 touchdowns, and 8 interceptions, making him the first quarterback to ever throw for more than 30 touchdowns and fewer than 10 interceptions in a season.[11] He also rushed for 220 yards and 3 touchdowns. Wide receiver Todd Pinkston was also a reliable target, recording 36 catches for 676 yards.[12]

text: Philadelphia's running game was not as strong as their passing attack, ranking just 24th in the league in rushing yards (1,639).[10] Running back Brian Westbrook led the team with 812 rushing yards and 3 touchdowns, however he also led all NFL running backs in receiving with 73 receptions for 706 yards and 6 touchdowns.[10] Veteran running back Dorsey Levens was also a big contributor with 410 rushing yards. The Eagles' offensive line was led by Pro Bowl tackles Tra Thomas and Jon Runyan and center Hank Fraley.[10]

text: Three of their four starters in the defensive secondary were named to the Pro Bowl: Cornerback Lito Sheppard (1 sack, 5 interceptions, 172 return yards and 2 touchdowns), safety Michael Lewis (88 tackles, 2 forced fumbles, 1 sack, and 1 interception) and safety Brian Dawkins (3 sacks, 2 forced fumbles, 1 fumble recovery, and 4 interceptions for 40 return yards), while their fourth starter, cornerback Sheldon Brown, also enjoyed a solid year (89 tackles, 3 sacks, 1 forced fumble, and 2 interceptions).[10] Their defensive line was anchored by Pro Bowl defensive tackle Corey Simon (5.5 sacks) and defensive ends Jevon Kearse (7.5 sacks, Pro Bowl) and Derrick Burgess. Pro Bowl middle linebacker Jeremiah Trotter, who only started 9 games, recorded 69 tackles and 1 sack.[10]

text: The Eagles started the 2004 regular season with seven straight wins before suffering a loss to the 15-1 Steelers. After that, they finished the season with a 13–3 record.[10] Their only other 2 losses were in their last 2 games of the season, when they decided to rest all of their starters because they had already clinched the NFC #1 seed, and thus home-field advantage in the playoffs. However, during a December 19, 12–7 win over the Dallas Cowboys, Owens was seriously injured on a "horse-collar tackle" by Cowboys defensive back Roy Williams and had to miss the rest of the regular season and the playoffs.[10]

text: Playoffs[edit]

text: Despite the loss of Owens, the Eagles beat the Minnesota Vikings, 27–14, and the Atlanta Falcons, 27–10, in the playoffs with relative ease. McNabb recorded 21 out of 33 completions for 286 yards and two touchdowns, while receiver Freddie Mitchell scored two touchdowns in the victory over the Vikings. Although Minnesota quarterback Daunte Culpepper threw for 316 yards, the Eagles defense recorded 2 interceptions, 2 sacks, and a forced fumble. McNabb then completed 17 out of 26 passes for 180 yards and two touchdowns in the win over the Falcons.[10] The Eagles defense held dual-threat quarterback Michael Vick to only 136 passing yards, 26 rushing yards, and no touchdowns, while also recording an interception, 4 sacks, and a forced fumble on Vick. McNabb had an average passer rating of 111.3 in the two games, with 466 passing yards, 35 rushing yards, 4 touchdowns, and no turnovers. Safety Brian Dawkins was also an important player, recording a sack and a forced fumble against the Vikings, followed by an interception and a forced fumble against the Falcons.

text: Meanwhile, the Patriots defeated the Indianapolis Colts, 20–3, holding the league's highest scoring team with 522 total points to just one field goal, Indianapolis' lowest point total since their opening game of the 2003 season. Colts quarterback Peyton Manning threw for 4,557 yards during the regular season, and set NFL records for most touchdown passes in a regular season (49) and highest quarterback rating (121.4). [10] Running back Edgerrin James gained 2,031 combined rushing and receiving yards and scored 9 touchdowns. Wide receivers Marvin Harrison, Reggie Wayne, and Brandon Stokley each recorded over 1,000 receiving yards and 10 touchdowns. However, the Patriots limited Manning to 238 passing yards with 1 interception and no touchdowns, and James to just 39 rushing yards. [10] The Patriots also held possession of the ball for 37:43, including 21:26 in the second half, and recorded three long scoring drives that each took over 7 minutes off the clock. One reason New England was able to hold the ball so long was because of Dillon's rushing. He finished the game with 23 carries for 144 yards and 5 receptions for 17 yards. [10]

text: The Patriots then defeated the first seeded Steelers in the AFC Championship Game, 41–27. Although Pittsburgh had beaten New England, 34–20, during the regular season and led the league in fewest total yards allowed, they could not stop the Patriots. Brady threw for 207 yards and 2 touchdowns; Dillon rushed for 73 yards and a touchdown; and Branch, who was coming off of his injuries, recorded 4 receptions for 116 yards and a touchdown, along with 37 rushing yards and another touchdown on 2 carries. [10] Steelers quarterback Ben Roethlisberger (who had struggled the previous week against the New York Jets) was intercepted 3 times, and running back Jerome Bettis, Pittsburgh's leading rusher, was held to just 64 yards. [10]

text: Super Bowl pregame news[edit]

text: Owens was cleared to play in Super Bowl XXXIX, defying doctors orders by playing on his injured ankle containing 2 screws and a metal plate.[10]

text: The other major story was the Patriots' potential loss of both their offensive coordinator and defensive coordinator at the end of the season, and how it might affect the team in 2005. On December 12, 2004, about a month and a half before the game, New England offensive coordinator Charlie Weis signed a contract to become the head coach of Notre Dame starting in the 2005 season. [10] Rumors were also circulating that defensive coordinator Romeo Crennel would also leave the team to become the head coach of the Cleveland Browns (which ended up being true as Crennel and the Browns agreed to a contract a couple of weeks after the Super Bowl).[10]

text: Due to injuries at the tight end spot, the Eagles were forced to sign Jeff Thomason, a former tight end who was working construction at the time, to a one-game contract for the Super Bowl. Thomason saw time during several plays, although never had a ball thrown his way. This was his third Super Bowl, playing in two with the Green Bay Packers during Andy Reid's days as a Packer assistant.[10]

text: With this appearance the Patriots became the 8th team to make it to the Super Bowl for the 5th time.[10] They joined the Dallas Cowboys, Denver Broncos, Pittsburgh Steelers, San Francisco 49ers, Miami Dolphins, Washington Redskins, and Oakland/Los Angeles Raiders.[10] They would be joined by the Green Bay Packers in 2011 and the New York Giants in 2012.

text: The Eagles were trying to win their first NFL title since 1960 and the first championship for the city of Philadelphia since Moses Malone's "fo', fi', fo'" during the 76ers run to the 1983 NBA Championship.[13][14] With President George W. Bush being inaugurated for a second time in January, the Eagles were also trying to end a losing streak—teams in the city of Philadelphia had lost six straight championships during presidential inauguration years, beginning with the 76ers loss in 1977.[14] The streak included the Eagles in Super Bowl XV in 1981.[14] 1989 was not included in that streak, but 1977, 1981, 1985 (Flyers), 1993 (Phillies), 1997 (Flyers), and 2001 (76ers) were.

text: Television and entertainment[edit]

text: The game was televised in the United States by Fox, with play-by-play announcer Joe Buck and color commentators Cris Collinsworth and Troy Aikman. Pam Oliver (Patriots sideline) and Chris Myers (Eagles sideline) served as sideline reporters. This marked the first time since Super Bowl I that none of the network commentators had ever called a Super Bowl game before (although Collinsworth had worked three prior Super Bowl telecasts as a pregame analyst). This was the last game that Cris Collinsworth broadcast as a member of the Fox NFL team, as he chose to sign with NBC in the following off-season.

text: James Brown hosted all the events with help from his fellow Fox NFL Sunday cast members Terry Bradshaw, Howie Long, and Jimmy Johnson. Jillian Barberie served as weather and entertainment reporter.

text: Following the game, Fox aired a special episode of The Simpsons ("Homer and Ned's Hail Mary Pass") and the series premiere of American Dad! ("Pilot"), except in Philadelphia and Boston, where local newscasts delayed the premieres by an hour.

text: Pregame ceremonies[edit]

text: Before the game, performances came from the Black Eyed Peas, Earth Wind & Fire, Charlie Daniels, John Fogerty, and Gretchen Wilson. Shortly before kickoff, Alicia Keys sang "America the Beautiful," paying tribute to Ray Charles, who died in June 2004. The combined choirs of the U.S. Military Academy, the U.S. Naval Academy, the U.S. Air Force Academy, and the U.S. Coast Guard Academy (including members of The Idlers) sang the national anthem accompanied by the U.S. Army Herald Trumpets. This was the first time in more than 30 years that all four service academies sang together—the last time was at the second inauguration of President Richard Nixon in 1973.[10][15][16]

text: The traditional military missing man formation flyby was this year performed by a pair of F/A-18 Super Hornets from VFA-106 at NAS Oceana and a pair of the Air Force's newest fighters, the F-22 Raptor, flying from Tyndall AFB, the training base for the Raptor. The earlier military flyby during the veterans' salute was conducted by 2 T-6 Texan trainers and a B-25 Mitchell bomber.

text: The coin toss ceremony featured youth football players from Jacksonville: Tyler Callahan, Tyler Deal, Lawrence McCauley, and Jacob Santana; and New Orleans NFL Junior Player Development coach Tamaris Jackson.[10] They were billed as the first non-celebrities to participate in the coin toss.

text: For the third straight year, each team took the field en masse, following a tradition the Patriots had started in Super Bowl XXXVI. In prerecorded video segments, Andover, Massachusetts native Michael Chiklis introduced the Patriots, and Philadelphia-born Will Smith introduced the Eagles.

text: Halftime show[edit]

text: Paul McCartney performed during the halftime show; his selection by the NFL, the show's producers, Don Mischer Productions, and the show's sponsor, Ameriquest Mortgage, was considered to be a "safe" choice, as it avoided the possibility for an incident similar to that which sparked the Super Bowl XXXVIII halftime show controversy the previous year. McCartney's set consisted of these songs:

text:
"Drive My Car"
"Get Back"
"Live and Let Die" from his career with Wings.[10]
"Hey Jude"

text: Theme[edit]

text: Taking the concept a step further, for the first time, a theme was tied to the event: Building Bridges, as symbolized by the theme logo, represented by the Main Street Bridge, one of the seven bridges that crosses over the St. Johns River in the host city, and according to the League, symbolized the bridging of a nation under the NFL football umbrella. The theme was also used by Jacksonville-area nonprofit Fresh Ministries in a major event entitled "Bridges of Peace," featuring city officials asking the people to unite for the Super Bowl and heal the wounds of segregation.[10]

text: Presidential appearances[edit]

text: Former Presidents George H. W. Bush and Bill Clinton appeared in support of their bipartisan effort to raise money for relief of the December 26, 2004 tsunami in southeast Asia through the USA Freedom Corps, an action which former President Bush described as "transcending politics."

text: Game summary[edit]

text: First Quarter[edit]

text: On the first drive of the game, Eagles quarterback Donovan McNabb fumbled while being sacked by New England linebacker Willie McGinest, and the Patriots recovered the ball at Philadelphia's 34-yard line. Fortunately for the Eagles, coach Andy Reid's instant replay challenge overruled the fumble; officials ruled that McNabb had been down by contact before the ball came out of his hands. Later in the quarter after each team had punted twice, McNabb completed a 30-yard pass to Terrell Owens, with a roughing the passer penalty adding 9 yards, moving the ball inside the Patriots 20-yard line. However, linebacker Mike Vrabel sacked McNabb for a 16-yard loss on the next play. On the following play, the Eagles once again appeared to turn the ball over: McNabb's pass was intercepted in the end zone by Patriots defensive back Asante Samuel, but it was nullified by an illegal contact penalty on linebacker Roman Phifer, moving the ball back inside the 20 and giving the Eagles a first down. However, McNabb's second chance was wasted as he threw an interception to safety Rodney Harrison on the next play. This was Donovan McNabb's first Red zone interception of the season.

text: The Eagles defense then forced New England to a three-and-out on their ensuing possession, and Philadelphia got great field position by receiving the punt at the Patriots 45-yard line. But once again, they gave up another turnover: tight end L.J. Smith lost a fumble while being tackled by defensive back Randall Gay, and Eugene Wilson recovered the ball at the 38.

text: Second Quarter[edit]

text: The Eagles defense once again forced New England to punt, and got the ball back at their own 19-yard line. Aided by a pair of completions from McNabb to receiver Todd Pinkston for gains of 17 and 40 yards, the Eagles drove 81 yards in 9 plays and scored on McNabb's 6-yard touchdown pass to Smith, taking a 7–0 lead with 9:55 left in the second quarter. It was the first time New England trailed during the entire postseason. On their ensuing drive, the Patriots moved the ball to the Eagles 4-yard line, mainly on plays by Corey Dillon, who caught two screen passes for 29 yards and rushed for 25. But quarterback Tom Brady fumbled the ball on a fake handoff Play-action pass and Philadelphia defender Darwin Walker recovered it. However, the Eagles could not take advantage of the turnover and had to punt after 3 plays. Eagles punter Dirk Johnson's punt went just 29 yards, giving the Patriots the ball at Philadelphia's 37-yard line. The Patriots then drove 37 yards to score on Brady's 4-yard pass to receiver David Givens with 1:10 remaining in the period, tying the game 7–7 by halftime. It was only the second halftime tie in Super Bowl history and the first time both of the game's first 2 quarters ended tied.

text: Third Quarter[edit]

text: On the opening drive of the second half, Patriots receiver Deion Branch caught 4 passes for 71 yards on a drive that ended with Brady's 2-yard touchdown pass to Vrabel, who lined up at the tight end spot on the play. The Eagles later tied the game with 3:39 left in the third period with a 74-yard, 10-play drive that was capped by McNabb's 10-yard touchdown pass to running back Brian Westbrook. For the first time in Super Bowl history, the game was tied going into the fourth quarter.

text: Fourth Quarter[edit]

text: Early in the final period, the Patriots put together a 9-play, 66-yard scoring drive that was keyed by 3 plays from running back Kevin Faulk, who caught 2 passes for 27 combined yards and rushed once for 12. Dillon capped off the drive with a 2-yard touchdown run to give the Patriots a 21–14 lead. Then after forcing another Eagles punt, Branch made a spectacular catch, taking the ball out of the hands of cornerback Sheldon Brown. The 19 yard gain, and a roughing-the-passer penalty on Philadelphia defensive lineman Corey Simon on the same play, set up kicker Adam Vinatieri's 22-yard field goal with 8:43 left in the game to increase the score 24–14 in favor of New England. In all three Patriots' Super Bowl wins in the decade, they held a double digit lead in the 4th quarter.

text: The Eagles responded with a long McNabb completion to Owens. However, after reaching the New England 36-yard line, McNabb fired a pass over the head of Dorsey Levens, where Tedy Bruschi was waiting to intercept it at the Patriots 24-yard line. At this point, there was only 7:20 to play in the game, with the Patriots still up by 10 points.

text: The Eagles did force New England to punt, and got the ball back at their own 21-yard line, but with 5:40 left in the game. The Eagles then drove 79 yards in 13 plays, however they used a full huddle for the entire drive. McNabb's 30-yard touchdown pass to receiver Greg Lewis cut the deficit to 24-21. Because the Eagles used a full huddle, the drive consumed 3:52 of the clock, and only 1:48 remained in the game by the time Lewis scored. Because of this, many sportswriters later criticized the Eagles for not immediately going to a no-huddle offense at the start of the possession. Anecdotal reports later came out alleging that McNabb was suffering from dry-heaves, and teammates Jon Ritchie[17] and Lito Sheppard[18] have gone on record years later that McNabb was suffering from dry-heaves or vomiting, though no video evidence exists and the stories have not been confirmed. Hank Fraley said in an interview the day after the game that McNabb was "almost puking" due to two large hits from Tedy Bruschi and Jarvis Green on back-to-back plays.[19] McNabb himself denies that he was vomiting or dry-heaving during the final drive, and Brian Westbrook later claimed that McNabb was merely "coughing."[17]

text: The Eagles failed to recover their ensuing onside kick attempt, with Christian Fauria catching the ball cleanly and sliding down to seal possession for New England. The Patriots then played it safe by running the ball 3 times and forcing Philadelphia to use all of its timeouts. New England punter Josh Miller then pinned the Eagles back at their own 4-yard line with just 46 seconds left in the game. Philadelphia then tried one last desperate drive to win or tie the game. But on first down, McNabb was pressured into making a rushed pass to Westbrook at the line of scrimmage. Instead of dropping the pass to stop the clock, Westbrook made the mistake of catching the ball and was immediately tackled for no gain, keeping the clock running and forcing the Eagles to run back to the line of scrimmage for their next play with no huddle. On second down, McNabb threw an incomplete pass intended for Owens. Finally on third down, McNabb threw a pass that deflected off of the outstretched fingertips of Smith and into the arms of Harrison for an interception with nine seconds left. Tom Brady took a knee to run out the clock, clinching the 3rd Super Bowl title in 4 years for the Patriots, and in the eyes of many establishing themselves as a dynasty.

text:
Adam Vinatieri warms up before the game

An Eagles offensive play

Philadelphia kicks off after scoring a touchdown

Brian Westbrook's touchdown catch (photo 1 of 2)

Brian Westbrook's touchdown catch (photo 2 of 2)

text: Box score[edit]

text:
1
2
3
4
Total

Patriots
0
7
7
10
24

Eagles
0
7
7
7
21

text: at Alltel Stadium, Jacksonville, Florida

text:
Date: February 6, 2005
Game time: 6:38 p.m. EST
Game weather: 59 °F (15 °C), clear

text:
[hide]Scoring summary

Quarter
Time
Drive
Team
Scoring information
Score

Plays
Yards
TOP
NE
PHI

2
9:55
9
81
4:36
PHI
L. J. Smith 6-yard touchdown reception from McNabb, Akers kick good
0
7

2
1:10
7
37
3:15
NE
Givens 4-yard touchdown reception from Brady, Vinatieri kick good
7
7

3
11:04
9
69
3:56
NE
Vrabel 2-yard touchdown reception from Brady, Vinatieri kick good
14
7

3
3:35
10
74
4:17
PHI
Westbrook 10-yard touchdown reception from McNabb, Akers kick good
14
14

4
13:44
9
66
4:51
NE
Dillon 2-yard touchdown run, Vinatieri kick good
21
14

4
8:40
8
43
3:49
NE
22-yard field goal by Vinatieri
24
14

4
1:48
13
79
3:52
PHI
Lewis 30-yard touchdown reception from McNabb, Akers kick good
24
21

"TOP" = time of possession. For other American football terms, see Glossary of American football.
24
21

text: Statistical overview[edit]

text: McNabb completed 30 out of 51 passes for 357 yards and 3 touchdowns, but threw 3 interceptions and was sacked four times. McNabb's 357 yards are tied with Joe Montana for the fifth most in Super Bowl history and third most of any quarterback, as Tom Brady holds the top spot with 466 yards in Super Bowl LI and Kurt Warner holds the following 3 spots. Westbrook was the Eagles leading rusher with 44 yards, while also catching 6 passes for 70 yards and a touchdown and returning 3 punts for 19 yards. Pinkston caught 4 passes for 82 yards, while Owens was the Eagles' top receiver with 9 catches for 122 yards, however neither of them scored a touchdown.

text: Brady completed 23 out of 33 passes for 236 yards and 2 touchdowns. Dillon was the top rusher of the game with 75 yards and a touchdown, and had 3 catches for 31 yards. Branch's Super Bowl record 11 catches tied Cincinnati Bengals' Dan Ross in Super Bowl XVI and San Francisco 49ers' Jerry Rice in Super Bowl XXIII. Coincidentally, all three would later be traded to the Seattle Seahawks: Ross in 1985, Rice in 2004 and Branch in 2006. Branch's 21 catches in Super Bowls XXXVIII and XXXIX are the most in back-to-back Super Bowls. Running back Kevin Faulk contributed 38 rushing yards and 27 receiving yards.

text: Branch and Terrell Owens each had 100 yards receiving, marking the third time in Super Bowl history, one player from each team had over 100 yards in a Super Bowl. Michael Irvin and Andre Reed were the first in Super Bowl XXVII, and Branch and Muhsin Muhammad the second a year earlier in Super Bowl XXXVIII. Branch also became the fourth player to have at least 100 yards receiving in back-to-back Super Bowls, joining John Stallworth, Jerry Rice and Antonio Freeman. Also, Mike Vrabel and David Givens became just the 14th and 15th players to score a touchdown in consecutive Super Bowls. Vrabel is the most surprising person on this list because he is a linebacker and he scored his on offense. They also became just the 7th and 8th players to catch a touchdown in back-to-back Super Bowls.

text: With the victory, Tom Brady became just the fourth quarterback to win at least three Super Bowls. He joined Terry Bradshaw, Joe Montana and Troy Aikman on this exclusive list. Brady also became the fourth quarterback to throw a touchdown pass in three different Super Bowls. Other quarterbacks to do it were Terry Bradshaw, Joe Montana and John Elway, with Kurt Warner later accomplishing the feat during Super Bowl XLIII.

text: The Patriots joined the Dallas Cowboys as the only teams in NFL history to win three Super Bowls in a span of four years.

text: Aftermath[edit]

text: The Patriots' Super Bowl win was the third championship for Boston-area sports teams in 12 months, following the Patriots winning Super Bowl XXXVIII the year before and the Red Sox winning the World Series–first in 86 years–three months earlier. This marked the first time since 1989–1990 in the San Francisco Bay Area that the same market has had 2 Super Bowl and World Series winners in 12 months.[13] The Patriots would later appear in Super Bowl XLII and Super Bowl XLVI, losing both to Eli Manning's New York Giants, before winning Super Bowl XLIX against the Seattle Seahawks, 28–24, ten years later and Super Bowl LI against the Atlanta Falcons, 34-28, two years later. The latest Super Bowl win for the Patriots makes it ten titles among the four Boston teams (5 by the Patriots, 3 by the Red Sox, and one each by the Celtics and Bruins) since 2002.

text: For the Eagles, with the loss, the city of Philadelphia would not see its first championship since the 76ers swept the 1983 NBA Finals until the next time their city's teams played for a championship, when the Phillies won the 2008 World Series.[14] The Eagles have yet to return to the Super Bowl since.

text: Final statistics[edit]

text: Sources: NFL.com Super Bowl XXXIX, Super Bowl XXXIX Play Finder NE, Super Bowl XXXIX Play Finder Phi

text: Statistical comparison[edit]

text:
New England Patriots
Philadelphia Eagles

First downs
21
24

First downs rushing
6
4

First downs passing
14
18

First downs penalty
1
2

Third down efficiency
4/12
9/16

Fourth down efficiency
0/0
0/0

Net yards rushing
112
45

Rushing attempts
28
17

Yards per rush
4.0
2.6

Passing – Completions–attempts
23/33
30/51

Times sacked–total yards
2–17
4–33

Interceptions thrown
0
3

Net yards passing
219
324

Total net yards
331
369

Punt returns–total yards
4–26
3–19

Kickoff returns–total yards
4–63
5–114

Interceptions–total return yards
3–5
0–0

Punts–average yardage
7–45.1
5–42.8

Fumbles–lost
1–1
2–1

Penalties–yards
7–47
3–35

Time of possession
31:37
28:23

Turnovers
1
4

text: Individual leaders[edit]

text:
Patriots Passing

C/ATT1
Yds
TD
INT
Rating

Tom Brady
23/33
236
2
0
110.2

Patriots Rushing

Car2
Yds
TD
LG3
Yds/Car

Corey Dillon
18
75
1
25
4.17

Kevin Faulk
8
38
0
12
4.75

Patrick Pass
1
0
0
0
0.00

Tom Brady
1
−1
0
−1
-1.00

Patriots Receiving

Rec4
Yds
TD
LG3
Target5

Deion Branch
11
133
0
27
12

Corey Dillon
3
31
0
16
4

David Givens
3
19
1
13
7

Kevin Faulk
2
27
0
14
2

Troy Brown
2
17
0
12
2

Daniel Graham
1
7
0
7
1

Mike Vrabel
1
2
1
2t
1

David Patten
0
0
0
0
4

text:
Eagles Passing

C/ATT1
Yds
TD
INT
Rating

Donovan McNabb
30/51
357
3
3
75.4

Eagles Rushing

Car2
Yds
TD
LG3
Yds/Car

Brian Westbrook
15
44
0
22
2.93

Dorsey Levens
1
1
0
1
1.00

Donovan McNabb
1
0
0
0
0.00

Eagles Receiving

Rec4
Yds
TD
LG3
Target5

Terrell Owens
9
122
0
36
14

Brian Westbrook
7
60
1
15
11

Todd Pinkston
4
82
0
40
7

Greg Lewis
4
53
1
30t
5

L. J. Smith
4
27
1
9
8

Freddie Mitchell
1
11
0
11
4

Josh Parry
1
2
0
2
1

Dorsey Levens
0
0
0
0
1

text: 1Completions/attempts 2Carries 3Long gain 4Receptions 5Times targeted

text: Starting lineups[edit]

text:
New England
Position
Position
Philadelphia

Offense

David Givens
WR
Todd Pinkston

Matt Light
LT
Tra Thomas

Joe Andruzzi
LG
Artis Hicks

Dan Koppen
C
Hank Fraley

Stephen Neal
RG
Jermane Mayberry

Brandon Gorin
RT
Jon Runyan

Daniel Graham
TE
L. J. Smith

Deion Branch
WR
Terrell Owens

Tom Brady‡
QB
Donovan McNabb

Corey Dillon
RB
Brian Westbrook

Patrick Pass
FB
Josh Parry

Defense

Rosevelt Colvin
OLB
LDE
Derrick Burgess

Vince Wilfork
NT
LDT
Corey Simon

Jarvis Green
RE
RDT
Darwin Walker

Mike Vrabel
OLB
RDE
Jevon Kearse

Tedy Bruschi‡
ILB
WLB
Keith Adams

Roman Phifer
ILB
MLB
Jeremiah Trotter

Willie McGinest‡
OLB
SLB
Dhani Jones

Randall Gay
LCB
Lito Sheppard

Asante Samuel
RCB
Sheldon Brown

Rodney Harrison
SS
Michael Lewis

Eugene Wilson
FS
Brian Dawkins

text: Commercials[edit]

text: As usual, the television coverage of this year's Super Bowl was the showcase for the most expensive commercials in television—both to produce and to buy airtime (at the rate of $2.4 million US for 30 seconds).[10]

text: One ad that drew the ire of many—including the NFL—was for the internet domain provider Go Daddy, which tweaked the controversial halftime of the previous year's game with a mock censorship hearing featuring a comely woman, Nikki Cappelli (played by WWE Wrestler Candice Michelle), having a "wardrobe malfunction". Fox pulled the second airing of the ad, scheduled for the two-minute warning of the fourth quarter, along with a five-second plug, and it was replaced with a promo for The Simpsons. The Scottsdale, Arizona-based World Wide Web domain registration company got a refund on the second ad.[10]

text: Another popular ad was made by the NFL. It featured players who were not in the Super Bowl, headlined by Pittsburgh Steelers rookie quarterback Ben Roethlisberger being at a beach resort, depressed he did not make it in. Joe Montana comforted Roethlisberger, and soon both Montana and Roethlisberger joined many other players in different locations in an off-key yet rousing edition of "Tomorrow" from the musical Annie. The commercial ended with the tagline: "Tomorrow, we're all undefeated again." Roethlisberger would go on to lead the Steelers to victory in Super Bowl XL the very next season.

text: The top ad, as chosen by the USA Today Super Bowl Ad Meter was for Anheuser-Busch's Bud Light featuring a timid skydiver making his first jump getting enticed with a six-pack of the product.[10] This ad was ranked second on ADBOWL. The highest ranked commercial by ADBOWL was Anheuser-Busch's "Applause."

text: For the first time since the campaign started in Super Bowl XXI, no "I'm going to Disney World!" ad aired following Super Bowl XXXIX.[10]

text: Player bonuses[edit]

text: Each member of the Patriots received a payment of $68,000 for winning the game. The Eagles each received $36,500. When adjusted for inflation, the Patriots salary was actually less than the $15,000 paid to members of the Green Bay Packers for winning Super Bowl I in 1967. That amount of money in 1967 equated to approximately $85,000 in 2005.[21]

text: Officials[edit]

text:
Referee: Terry McAulay #77 first Super Bowl
Umpire: Carl Paganelli #124 first Super Bowl
Head Linesman: Gary Slaughter #30 first Super Bowl
Line Judge: Mark Steinkerchner #84 second Super Bowl (XXXVII)
Field Judge: Tom Sifferman #118 third Super Bowl (XXXVII, XXXVIII)
Side Judge: Rick Patterson #15 second Super Bowl (XXXV)
Back Judge: Tony Steratore #112 first Super Bowl
Alternate Referee: Ed Hochuli #85 (referee for XXXII, XXXVIII)
Alternate Umpire: Garth DeFelice #53
Alternate Field Judge: Larry Rose #128[10]


document_title: Book design

question_text: list of chapters in a book is called

question_tokens: list of chapters in a book is called

text: Book design

text: Structure[edit]

text: Modern books are paginated consecutively, and all pages are counted in the pagination whether or not the numbers appear. The page number, or folio, is most commonly found at the top of the page, flush left verso, flush right recto. The folio may also be printed at the bottom of the page, and in that location it is called a drop folio. Drop folios usually appear either centered on each page or flush left verso and flush right recto.[3]

text: Front matter[edit]

text: Front matter (or preliminaries; shortened to "prelims") comprises the first section of a book, and is usually the smallest section in terms of the number of pages. Front-matter pages are traditionally numbered in lower-case Roman numerals (i, ij, iij, iv, v, etc.), which prevents renumbering the remainder of a book when front-matter content is added at the last moment, such as a dedication page or additional acknowledgments. Page number is omitted on blank pages and display pages (i.e., such stand-alone pages as those for the half title, frontispiece, title page, colophon, dedication, and epigraph), and it is either omitted or a drop folio is used on the opening page of each section of the front matter (e.g., table of contents, foreword, preface).[3] Front matter generally appears only in the first of a multi-volume work, although some elements (such as a table of contents or index) may appear in each volume.

text: The following table defines some common types of front matter, and the "voice" (or point of view) in which each can be said to be given:

text:
Name
Voice
Purpose

Half title
Publisher
Usually a single line in capital letters, precedes the title page, and only contains the title (as opposed to the author, publisher etc. found on the full title page) with a blank verso.

Frontispiece
Author or publisher
A decorative illustration on the verso facing the title page. It may be related to the book's subject, or be a portrait of the author.

Title page
Publisher
Repeats the title and author as printed on the cover or spine.

Colophon
Printer
Technical information such as edition dates, copyrights, typefaces and the name and address of the printer. In modern books usually on the verso of the title page, but in some books placed at the end (see Back matter). Also known as the Edition notice or Copyright page.

Dedication
Author
A dedication page is a page in a book that precedes the text, in which the author names the person or people for whom he/she has written the book.

Epigraph
Author
A phrase, quotation, or poem. The epigraph may serve as a preface, as a summary, as a counter-example, or to link the work to a wider literary canon, either to invite comparison, or to enlist a conventional context.

Table of contents
Publisher
This is a list of chapter headings, and nested subheadings, together with their respective page numbers. This includes all front-matter items listed below, together with chapters in the body matter and back matter. The number of levels of subheadings shown should be limited, so as to keep the contents list short, ideally one page, or possibly a double-page spread. Technical books may include a list of figures and a list of tables.

Foreword
Some person other than the author
Often, a foreword will tell of some interaction between the writer of the foreword and the story or the writer of the story. A foreword to later editions of a work often explains in what respects that edition differs from previous ones.

Preface
Author
A preface generally covers the story of how the book came into being, or how the idea for the book was developed. This is often followed by thanks and acknowledgments to people who were helpful to the author during the time of writing.

Acknowledgments
Author
Often part of the preface, rather than a separate section in its own right, it acknowledges those who contributed to the creation of the book.

Introduction
Author
A beginning section which states the purpose and goals of the following writing.

Prologue
Narrator (or a character in the book)
A prologue is an opening to a story that establishes the setting and gives background details, often some earlier story that ties into the main one, and other miscellaneous information. As such, it is generally considered part of the body in modern book organization (cf. Chicago Manual of Style).

text: Body matter[edit]

text: The structure of a work—and especially of its body matter—is often described hierarchically.

text:
Volumes

A volume is a set of leaves bound together. Thus each work is either a volume, or is divided into volumes.

Books and parts

Single-volume works account for most of the non-academic consumer market in books. A single volume may embody either a part of a book or the whole of a book; in some works, parts encompass multiple books, while in others, books may consist of multiple parts.

Chapters and sections

A chapter or section may be contained within a part or a book. When both chapters and sections are used in the same work, the sections are more often contained within chapters than the reverse.

Modules and units

In some books the chapters are grouped into bigger parts, sometimes called modules. The numbering of the chapters can begin again at the start of every module. In educational books, especially, the chapters are often called units.

text: The first page of the actual text of a book is the opening page, which often incorporates special design features, such as initials. Arabic numbering starts at this first page. If the text is introduced by a second half title or opens with a part title, the half title or part title counts as page one. As in the front matter, page numbers are omitted on blank pages, and are either omitted or a drop folio is used on the opening page of each part and chapter. On pages containing only illustrations or tables, page numbers are usually omitted, except in the case of a long sequence of figures or tables.[3]

text: The following are two instructive examples:

text:
The Lord of the Rings has three parts (either in one volume each, or in a single volume), with each part containing two books, each containing, in turn, multiple chapters.
The Christian Bible (usually bound as a single volume) is divided into two "testaments" (which might more typically be described as "parts", and differ in length by a factor of three or four), each containing dozens of books, each in turn containing multiple chapters, which are most often divided (for purposes of citation) into "verses" each containing roughly one independent clause.

text: Back matter (end matter)[edit]

text: The back matter, also known as end matter, if used, normally consists of one or more of the following components:

text:
Name
Voice
Purpose

Epilogue
The narrator (or a character in the book)
This piece of writing at the end of a work of literature or drama is usually used to bring closure to the work.

Extro or Outro

The conclusion to a piece of work; this is considered the opposite of the intro. These terms are more commonly used in music.

Afterword
The author, or some other real person
An afterword generally covers the story of how the book came into being, or of how the idea for the book was developed.

Conclusion
Author

Postscript

Appendix or Addendum
Author
This supplemental addition to a given main work may correct errors, explain inconsistencies or otherwise detail or update the information found in the main work.

Glossary
Author
The glossary consists of a set of definitions of words of importance to the work. They are normally alphabetized. The entries may consist of places and characters, which is common for longer works of fiction.

Bibliography
Author
This cites other works consulted when writing the body. It is most common in non-fiction books or research papers.

Index
Publisher
This list of terms used in the text contains references, often page numbers, to where the terms can be found in the text. Most common in non-fiction books.

Colophon
Publisher
This brief description may be located at the end of a book or on the verso of the title page. It describes production notes relevant to the edition and may include a printer's mark or logotype.

Postface

text: Arabic numbering continues for the back matter.

text: Front cover, spine, and back cover of the dust-jacket[edit]

text: The front cover is the front of the book, and is marked appropriately by text or graphics in order to identify it as such (namely as the very beginning of the book). The front cover usually contains at least the title or author, with possibly an appropriate illustration.

text: On the inside of the cover page, extending to the facing page is the front endpaper sometimes referred as FEP. The free half of the end paper is called a flyleaf. Traditionally, in hand-bound books, the endpaper was just a sheet of blank or ornamented paper physically masking and reinforcing the connection between the cover and the body of the book. In modern publishing it can be either plain, as in many text-oriented books, or variously ornamented and illustrated in books such as picture books, other children's literature, some arts and craft and hobbyist books, novelty/gift-market and coffee table books, and graphic novels. These books have an audience and traditions of their own where the graphic design and immediacy is especially important and publishing tradition and formality are less important.

text: The spine is the vertical edge of a book as it normally stands on a bookshelf. It is customary for it to have printed text on it. In texts published or printed in the United States and the United Kingdom, the spine text, when vertical, runs from the top to the bottom, such that it is right side up when the book is lying flat with the front cover on top. In books from continental Europe, vertical spine text traditionally runs from the bottom up, though this convention has been changing lately.[4] The spine usually contains all, or some, of four elements (besides decoration, if any), and in the following order: (1) author, editor, or compiler; (2) title; (3) publisher; and (4) publisher logo.

text: On the inside of the back cover page, extending from the facing page before it, is the endpaper. Its design matches the front endpaper and, in accordance with it, contains either plain paper or pattern, image etc.

text: The back cover often contains biographical matter about the author or editor, and quotes from other sources praising the book. It may also contain a summary or description of the book

text: Binding[edit]

text: Books are classified under two categories according to the physical nature of their binding. The designation hardcover (or hardback) refers to books with stiff covers, as opposed to flexible ones. The binding of a hardcover book usually includes boards (often made of paperboard) covered in cloth, leather, or other materials. The binding is usually sewn to the pages using string stitching.

text: A less expensive binding method is that used for paperback books (sometimes called softback or softcover). Most paperbacks are bound with paper or light cardboard, though other materials (such as plastic) are used. The covers are flexible and usually bound to the pages using glue (perfect binding). Some small paperback books are sub-classified as pocketbooks. These paperbacks are smaller than usual—small enough to barely fit into a pocket (especially the back pocket of one's trousers). However, this capacity to fit into a pocket diminishes with increasing number of pages and increasing thickness of the book. Such a book may still be designated as a pocketbook.

text: Other items[edit]

text: Some books such as Bibles or dictionaries may have a thumb index to help find material quickly. Gold leaf may also be applied to the edges of the pages, so that when closed, the side, top, and bottom of the book have a golden color. On some books, a design may be printed on the edges, or marbling or a simple colour applied. Some artist's books go even further, by using fore-edge painting. Pop-up elements and fold-out pages may be used to add dimensions to the page in different ways. Children's books commonly incorporate a wide array of design features built into the fabric of the book. Some books for preschoolers include textured fabric, plastic on other materials. Die-cut techniques in the work of Eric Carle are one example. Clear or reflective surfaces, flaps, textiles and scratch-and-sniff are other possible features.

text: Page spread[edit]

text: A basic unit in book design is the page spread. The left page (called verso) and right page (called recto) are of the same size and aspect ratio, and are centered on the gutter where they are bound together at the spine.

text: The design of each individual page, on the other hand, is governed by the canons of page construction.

text: The possible layout of the sets of letters of the alphabet, or words, on a page is determined by the so-called print space, and is also an element in the design of the page of the book. Clearly, there must be sufficient space, at the spine of the book, if the text is to be visible. On the other hand, the other three margins of the page, which frame the book, are made of the appropriate size for both practical and aesthetic reasons.

text: Print space[edit]

text: The print space (German Satzspiegel) is a typographic term and determines the effective area on the paper of a book, journal or other press work. The print space is limited by the surrounding borders, or in other words the gutters outside the printed area.

text: The German term comes originally from hot-metal typesetting: above the desktop was a mirror (German: Spiegel) where the typesetter could read the inverted letters.


document_title: Pacific Ocean theater of World War II

question_text: what was the last major battle in the pacific wwii

text: Pacific Ocean theater of World War II

text:
[show]

v
t
e

Campaigns of World War II

Europe

Poland
Phoney War
Winter War
Denmark & Norway
France & Benelux
Britain
Balkans
Eastern Front
Finland
Western Front (1944–45)

Pacific War

China
Pacific Ocean
South-East Asia
South West Pacific
Japan
Manchuria (1945)

Mediterranean and Middle East

North Africa
Horn of Africa
Mediterranean Sea
Adriatic
Malta
Yugoslavia
Iraq
Syria–Lebanon
Iran
Italy
Dodecanese
Southern France

Other campaigns

Atlantic
Arctic
Strategic bombing
America
French West Africa
Madagascar

Contemporaneous wars

Chinese Civil War
USSR–Japan Border Wars
French–Thai
Ecuadorian–Peruvian War
Ili Rebellion

text: The Pacific Ocean theater, during World War II, was a major theater of the war between the Allies and the Empire of Japan. It was defined by the Allied powers' Pacific Ocean Area command, which included most of the Pacific Ocean and its islands, while mainland Asia was excluded, as were the Philippines, the Dutch East Indies, Borneo, Australia, most of the Territory of New Guinea and the western part of the Solomon Islands.

text: It officially came into existence on March 30, 1942, when US Admiral Chester Nimitz was appointed Supreme Allied Commander Pacific Ocean Areas.[1] In the other major theatre in the Pacific region, known as the South West Pacific theatre, Allied forces were commanded by US General Douglas MacArthur. Both Nimitz and MacArthur were overseen by the US Joint Chiefs and the Western Allies Combined Chiefs of Staff (CCoS).

text: Most Japanese forces in the theater were part of the Combined Fleet (聯合艦隊, Rengō Kantai) of the Imperial Japanese Navy (IJN), which was responsible for all Japanese warships, naval aircraft, and marine infantry units. The Rengō Kantai was led by Admiral Isoroku Yamamoto, until he was killed in an attack by U.S. fighter planes in April 1943.[2] Yamamoto was succeeded by Admiral Mineichi Koga (1943–44)[2] and Admiral Soemu Toyoda (1944–45).[3] The General Staff (参謀本部, Sanbō Honbu) of the Imperial Japanese Army (IJA) was responsible for Imperial Japanese Army ground and air units in Southeast Asia and the South Pacific. The IJN and IJA did not formally use joint/combined staff at the operational level, and their command structures/geographical areas of operations overlapped with each other and those of the Allies.

text: In the Pacific Ocean theater, Japanese forces fought primarily against the United States Navy, the U.S. Marine Corps and the U.S. Army. The United Kingdom, New Zealand, Australia, Canada and other Allied nations also contributed forces.

text: Major campaigns and battles[edit]

text:
Central Pacific Theater

Attack on Pearl Harbour 7 December 1941[4]
Battle of Wake Island 7–23 December 1941[5]
Doolittle Raid 18 April 1942[4]
Battle of the Coral Sea 4–8 May 1942
Battle of Midway 4–7 June 1942[4]
Guadalcanal Campaign 7 August 1942 to 9 February 1943
Gilbert and Marshall Islands campaign 1943–44

Makin Island raid 17–18 August 1942[6]
Battle of Tarawa 20 November 1943[4]
Battle of Makin 20–23 November 1943
Battle of Kwajalein 14 February 1944[7]
Battle of Eniwetok 17 February 1944[8]

Attack on Truk Island 17–18 February 1944
Mariana and Palau Islands campaign 1944

Battle of Saipan 15 June 1944[9]
Battle of the Philippine Sea 19–21 June 1944[10]
Battle of Guam 21 July 1944[11]
Battle of Tinian 24 July 1944[11]
Battle of Peleliu 15 September 1944[12]
Battle of Angaur 17 September 1944[12]

Battle of Leyte 20 October 1944[12]

Battle of Leyte Gulf 23 October 1944[12]

Battle of Iwo Jima 19 February 1945[4]
Battle of Okinawa 1 April 1945[4]

North Pacific Theater

Aleutian Islands Campaign 1942–43
Battle of the Komandorski Islands 26 March 1943[4]