document_title: History of wound care

question_text: when was alcohol first used as a disinfectant

text: History of wound care

text: Ancient medical practice[edit]

text: Over time, different civilizations began to create their own herbal medicinal treatments for wounds depending on the trees, shrubs, or any other type of plants located in their environment. These herbal treatments became the oldest form of wound therapy. It is logically assumed that this may not have been a very safe way of treating humans with wounds due to overdosing or choosing the wrong plants to treat a person until the right one was found. Nevertheless, most of the ancient people who were given the duty of healers through the usage of herbs were well accustomed with which plants from their local flora could be used to help the injured. This knowledge was learned and passed down after healers repeatedly used an herbal remedy for a specific wound with the belief that it promoted healing.[1]

text: Numerous ancient herbal remedies and poisons now serve as models for modern medicine. For example, curare, which was an ancient South American arrow poison, was used in the 20th century as the muscle relaxant tubocurarine.[2] Tribesmen conducted various observations on the effects of different plant parts, meaning roots, leaves, etc., on specific wounds. They also observed what seasons, time of day, or moon phase would result in a most active plant. The former however resulted in a minimal influence in modern medicine as compared to plants parts or seasons of growth.[1]

text: Ancient Greece[edit]

text: As tribal healers developed into doctors, it spurred on a primitive pharmaceutical industry that included traders who would travel overseas bringing herbs that would be used for specific wounds. Soon, like most industries, patients began to skip the doctors altogether and purchased the herbs directly from the traders who were also aware of the effects and quantities that should be taken while also informing their “patients” of them. These merchants that supplied people with herbs were known as rhizotomiki, or gatherers of roots, in Ancient Greece. The earliest known list of herbs and remedies was probably written for these herbal merchants. The earliest known to men is the Rhizotomika of Diocles of Carustius, a student of Greek philosopher Aristotle. This book includes the author’s observation of the effects of the herbal medicine on specific parts of the human body. This then became the beginning of scientific research on herbal remedies on humans, which has been modified and significantly changed from modern wound remedies.[1]

text: The Greeks also acknowledged the importance of wound closure, and were the first to differentiate between acute and chronic wounds, calling them "fresh" and "non-healing", respectively. Galen of Pergamum, a Greek surgeon who served Roman gladiators circa 120–201 A.D., made many contributions to the field of wound care.[3] The most important was the acknowledgment of the importance of maintaining wound-site moisture to ensure successful closure of the wound.[4]

text: Ancient Egypt[edit]

text: The clinical history of the treatment of acute and chronic wounds can also trace its origins to ancient Egypt. The Ebers Papyrus, circa 1500 BC, details the use of lint, animal grease, and honey as topical treatments for wounds. The lint provided its natural absorbency, the animal grease provided a barrier to environmental pathogens, and the honey served as an antibiotic agent.[5] The Brugsch Papyrus, circa 1200 BC, stated that the Egyptians believed that making sure a person's wound stayed closed would help their spirit not be invaded by evil spirits.[6][7]

text: Ancient herbs and medicines[edit]

text: There were many known herbs, minerals, and products that could help treat and remedy a variety of specific wounds in the ancient world; the following is a list that shows a set of substances that each were used with its own method and technique in regards to assisting wounds.

text: Turmeric[edit]

text: Turmeric is a well-known spice that is utilized in India for use in cooking and medical treatments. The implementation of Turmeric in medical administration can typically be explained by the factor that Curcumin is a component that is contained within Turmeric. Curcumin is an antioxidant that assists in reducing the pain and effect that is caused by inflammation, and furthermore, is found to accelerate the process of wound healing. In the historical times around some areas of India, the people who would practice this treatment would begin by applying a healthy amount of Turmeric paste onto the wounded area, followed by a wrapping of clothes around the area; in many tribal locations this treatment is still performed.[8]

text: Iron[edit]

text: Anemia is a disease that is caused be a deficiency of iron, where an individual doesn’t contain enough red-blood cells to transport sufficient oxygen to the exterior body organs, otherwise known as tissues. Thus, with the surplus of iron in additives such as, tablets, pills, and vegetables, the effects of such a disease can be hindered or even prevented. Furthermore, in relation to wounds, it is often recommended by many doctors and surgeons that patients are encouraged to intake food and medicine that are high in iron to accelerate wound healing.[8]

text: Honey[edit]

text: Honey was utilized for its antibacterial properties that helped heal infected wounds.[9] Moreover, honey was used as a topical ointment. Other than glucose, which is another name for sugar, honey also contains a variety of trace amounts of many different vitamins and amino acids, which are also known as proteins. The method used with honey, in regards to assisting medical treatments, mainly wounds, is by pouring and plastering a wholesome amount of it on the area of the wound. This technique will support in the reduction of pain, inflammation, and swelling. Furthermore, the antibacterial features that honey contains also constrain the wound from infection and growth.[8]

text: Alcohol[edit]

text: Various types of alcohol were also used in ancient medical practices. One of the first uses was by the Sumerians, who used beer as an antiseptic along with the dressing of wounds, using up to 19 different types of beer.[10] Other Ancient Arabic cultures, including the Sumerians and Akkadians used wine with sesame infusions, which were "purified and pulverized" before application along with the many beers.[11] Another peoples to take advantage of the cleansing properties of alcohol were the Greeks. They used wine along with boiled water and vinegar to cleanse wounds. The Greeks, specifically Hippocrates (430-377 bc), were also the first to establish the four cardinal signs of inflammation: redness, swelling, heat and pain.[10] Alcohol is still in use today as a wound cleanser largely as rubbing alcohol. However the side effects can be skin cell death resulting in inflammation and itchiness at the site of application.[12]

text: Middle Ages[edit]

text: There were limited advances that continued throughout the Middle Ages and the Renaissance, but the most profound advances, both technological and clinical, came with the development of microbiology and cellular pathology in the 19th century.

text: 19th century[edit]

text: The first advances in wound care in this era began with the work of Ignaz Philipp Semmelweis, a Hungarian obstetrician who discovered how hand washing and cleanliness in general in medical procedures prevents maternal deaths. Semmelweis's work was furthered by an English surgeon, Joseph Lister, who in 1860s began treating his surgical gauze with carbolic acid, known today as phenol, and subsequently dropped his surgical team's mortality rate by 45%. Building on the success of Lister's pretreated surgical gauze, Robert Wood Johnson I, co-founder of Johnson & Johnson, began in the 1890s producing gauze and wound dressings sterilized with dry heat, steam, and pressure.[13] These innovations in wound-site dressings marked the first major steps forward in the field since the advances of the Egyptians and Greeks centuries earlier. In 1886, Ernst von Bergmann introduced heat sterilization of surgical instruments, which marked the beginning of aseptic surgery and significantly reduced the frequency of infections. Conrad Brunner did extensive research into wound management and experimentation with wound disinfection methods, publishing his comprehensive Erfahrungen und Studien über Wundinfektion und Wundbehandlung[14] in 1898. That same year, Paul Leopold Friedrich introduced wound excision and experimentally showed that excision of open wounds substantially reduced the risk of infection. The next advances would arise from the development of polymer synthetics for wound dressings and the "rediscovery" of moist wound-site care protocols in the mid 20th century.

text: Wound-site dressing[edit]

text: During World War I, chemist Henry Drysdale Dakin was consulted and invented Dakin's Solution, sodium hypochlorate and boric acid, to wash out the traumatic wounds of British soldiers fighting in France.[15]

text: 1950s onward[edit]

text: The advent in the 1950s of fibrous synthetics such as nylon, polyethylene, polypropylene, and polyvinyls provided new materials from which researchers and doctors in the field of wound care could explore better protecting of healing wounds and even accelerating the natural wound healing process.

text: In the 1960s, research and articles by George Winter and Howard Maibach reported on the superior efficacy of moist wound dressings. The adoption of moist wound dressing technique as recommended best wound dressing practice reflected a large advance in approach producing markedly superior clinical outcomes. This dawn of modern wound care treatment initiated a process of improvement in the clinician's ability to bolster wound-site re-epithelialization and healing. The focus on evidence-based best practices and research continues.

text: In the 1990s, improvements in composite and hybrid polymers expanded the range of materials available for wound dressing. Grafting and biotechnology have produced usable and useful protective covering of actual human skin generated through cloning procedures. These improvements, coupled with the developments in tissue engineering, have given rise to a number of new classes of wound dressings. One of these, "living skin equivalents, " is often cited as a misnomer because they lack key components of whole living skin. "Living skin equivalents" may have the potential to serve as cellular platforms for the release of growth factors essential for proper wound healing. Many biologics, skin substitutes, biomembranes and scaffolds have been developed to facilitate wound healing through various mechanisms.[16]

text: Other recent developments has been the renewed focus on the prominent patient concern of pain. Burn patients and others affected by severe wounds often report pain as the dominant negative impact of the wounds on their lives.[17] Clinical management of the pain associated with chronic wounds has been an emergency wound treatment priority and is now viewed as an integral part of treatment.

text: Modern wound care[edit]

text: In modern-day 21st century, medicine has evolved to involve past treatments such as leech therapy, as well as advancing wound prevention and the treatment. A large part of wound care is wound treatment. This involves promoting healing, preventing infections, and getting rid of an already existent infection. Deciding on a treatment depends on the type of wound that a person has sustained. Varying from infections to burns, wound care is a priority in saving the limb, extremity, or life of a person. In a hospital or medical care setting, more severe wounds like diabetic ulcers, decubitus ulcers, and burns require sterile or clean (depending on the severity of the wound) dressings and wound care. The types of wound dressing include: dry dressings, wet-to-dry dressings, chemical-impregnated dressings, foam dressings, alginate dressings, hydrofiber dressings, transparent film dressings, hydrogel dressings, and hydrocolloid dressings. All of the listed dressing types require different materials to complete the dressing.

text:
Dry dressings: these dressings are typically composed of a gauze material and used for wounds with a small amount of drainage. These dressings are good for keeping the wound covered after cleaning and to promote healing as well as taking out small amounts of infection.
Wet-to-dry dressings: Although some medical facilities are stepping away from these types of dressings, they are used mostly for post-surgical wound care as well as debridement of wounds. These dressings take out necrotic areas as well as infections. In this type of wound dressing, gauze is soaked in saline, placed lightly inside of the wound, and covered with a dry dressing. Once the gauze dries, it can be removed. It dries onto the infection or necrotic areas to remove them. These dressings are being replaced by Wound-Vacs, which are attached to a dressing directly onto the wound, and lightly but continuously, pull and suck exudate and fluids from the wound.
Chemical-impregnated dressings: these are provided by manufacturers and they contain chemicals and agents that promote the healing process. Some of these dressings come in sheets and require secondary dressings.
Foam dressings: dressings that require additional padding utilize foam pads to help absorb and provide a moist healing environment. They also act as a shield to the wound and prevent any damage from friction or pressure. They can be tricky when applying and removing due to the surrounding skin.
Alginate dressings: these dressings are composed of calcium, sodium salts and also provide a moist environment for the healing process. They are better used with a larger wound such as ulcers or donor sites.
Hydro-fiber dressings: these dressings are similar to alginate dressings when it comes to absorbing characteristics, but they do not affect hemostasis. They are composed in sheets which contain polymer carboxymethylcellulose and can be cut according to wound size and severity. However, when using these dressings, a secondary dressing is almost always required.
Transparent film dressings: this specific type of dressing is more like a plastic covering for the wound. It allows oxygen to reach it and help heal but does not absorb any fluids. Transparent film dressings are used primarily on dry wounds.
Hydrogel dressings: this type of dressing is more directed towards infected areas and those in need of a moist environment to heal properly. It helps promote the body's own natural functions of removing necrotic tissue. It is advised not to be used on dry wounds.
Hydrocolloid dressings: unlike transparent film dressings, hydrocolloid dressings do not allow oxygen to reach the wound. It is a wet-to-dry technique but is not recommended for infected areas. This type of dressing can last up to 7 days with a close eye and must be removed with care.[18]
Self-adaptive dressings: these super-absorbent fiber dressings rely on properties of smart polymers sensitive to humidity levels. The dressing material responds to changes in wound moisture in real time and, when needed, can reverse its function (switching from absorption to hydration and back) over each specific area of the wound and periwound.[19] This type of dressing can be used on most open wounds.

text: Alternative treatments for wounds: leeches and maggots[edit]

text: Medical leeches were cleared as a medical device in 2004 after being an indispensable tool in the 19th century. This unique use of creatures is utilized in many surgeries today. Leeches have the ability to assist with compromised tissue with the components of their saliva. Their saliva contains a local anesthetic, thrombin inhibitor, antibiotic properties and a histamine-like vasodilator. These capabilities help in surgeries such as transplants, skin grafts, and even reconstructive surgeries. The leeches help localize the wound and help produce blood flow. This is helpful in operations where blood clots occur and they help dilate the blood vessels.

text: Medical maggots were first utilized by military medical aids during World War 2. They worked as biomedical debriding agents by ingesting bacteria and break them down within their intestines. Maggots give off an enzyme that disinfects wounds and promotes healing and this is why they became the first organism in the United States that were used as a medical device in January 2004.[20]