document_title: Term limits in the United States

question_text: how long is the term for state senator

question_tokens: how long is the term for state senator

text: Term limits in the United States

text: Historical background[edit]

text: The Constitution[edit]

text: Term limits date back to the American Revolution, and prior to that to the democracies and republics of antiquity. The council of 500 in ancient Athens rotated its entire membership annually, as did the ephorate in ancient Sparta. The ancient Roman Republic featured a system of elected magistrates—tribunes of the plebs, aediles, quaestors, praetors, and consuls —who served a single term of one year, with re-election to the same magistracy forbidden for ten years (see cursus honorum).[1] According to historian Garrett Fagan, office holding in the Roman Republic was based on "limited tenure of office" which ensured that "authority circulated frequently", helping to prevent corruption.[1] An additional benefit of the cursus honorum or Run of Offices was to bring the "most experienced" politicians to the upper echelons of power-holding in the ancient republic.[1] Many of the founders of the United States were educated in the classics, and quite familiar with rotation in office during antiquity. The debates of that day reveal a desire to study and profit from the object lessons offered by ancient democracy.

text: Prior to independence, several colonies had already experimented with term limits. The Fundamental Orders of Connecticut of 1639, for example, prohibited the colonial governor from serving consecutive terms, setting terms at one year's length, and holding "that no person be chosen Governor above once in two years."[2] Shortly after independence, the Pennsylvania Constitution of 1776 set maximum service in the Pennsylvania General Assembly at "four years in seven".[3] Benjamin Franklin's influence is seen not only in that he chaired the constitutional convention which drafted the Pennsylvania constitution, but also because it included, virtually unchanged, Franklin's earlier proposals on executive rotation. Pennsylvania's plural executive was composed of twelve citizens elected for the term of three years, followed by a mandatory vacation of four years.[4]

text: The Articles of Confederation, adopted in 1781, established term limits for the delegates to the Continental Congress, mandating in Article V that "no person shall be capable of being a delegate for more than three years in any term of six years."[5]

text: On October 2, 1789, the Continental Congress appointed a committee of thirteen to examine forms of government for the impending union of the states. Among the proposals was that from the State of Virginia, written by Thomas Jefferson, urging a limitation of tenure, "to prevent every danger which might arise to American freedom by continuing too long in office the members of the Continental Congress".[6] The committee made recommendations, which as regards congressional term limits were incorporated unchanged into the Articles of Confederation (1781–89). The fifth Article stated that "no person shall be capable of being a delegate [to the continental congress] for more than three years in any term of six years".[7]

text: Term limits in the Constitution[edit]

text: In contrast to the Articles of Confederation, the federal constitution convention at Philadelphia omitted mandatory term limits from the second national frame of government, i.e. the U.S. Constitution of 1789 to the present.  At the convention,[8] some delegates spoke passionately against term limits such as Rufus King, who said "that he who has proved himself to be most fit for an Office, ought not to be excluded by the constitution from holding it."  The Electoral College, it was believed by some delegates at the convention, could have a role to play in limiting unfit officers from continuing.

text: George Washington set the informal precedent for a two-term limit for the Presidency—a tradition that prevailed until Franklin Roosevelt's presidency, after which the 22nd Amendment to the U.S. Constitution was ratified in 1951 formally establishing in law the two-term limit.

text: However, when the states ratified the Constitution (1787–88), several leading statesmen regarded the lack of mandatory limits to tenure as a dangerous defect, especially, they thought, as regards the presidency and the Senate. Richard Henry Lee viewed the absence of legal limits to tenure, together with certain other features of the Constitution, as "most highly and dangerously oligarchic".[9] Both Jefferson[10] and George Mason[11] advised limits on reelection to the Senate and to the Presidency, because said Mason, "nothing is so essential to the preservation of a Republican government as a periodic rotation". The historian Mercy Otis Warren, warned that "there is no provision for a rotation, nor anything to prevent the perpetuity of office in the same hands for life; which by a little well-timed bribery, will probably be done".[12]

text: 19th century[edit]

text: The fact that "perpetuity in office" was not approached until the 20th century is due in part to the influence of rotation in office as a popular 19th-century concept. "Ideas are, in truth, forces", and rotation in office enjoyed such normative support, especially at the local level, that it altered political reality.[13] For a detailed study of the 19th-century concepts of rotation, consult Political Science Quarterly, vol. 94, "House Turnover and the Principle of Rotation", by Robert Struble, Jr. See also his Treatise on Twelve Lights,[14] chapter six, "Rotation in History". Consult also, James Young's The Washington Community, 1800–1828.

text: According to Young, the tendency to look with mistrust upon political power was so ingrained into American culture that even the officeholders themselves perceived their occupations in a disparaging light.[15] James Fenimore Cooper described the common view that "contact with the affairs of state is one of the most corrupting of the influences to which men are exposed".[16] An article in the Richmond Enquirer (1822) noted that the "long cherished" principle of rotation in office had been impressed on the republican mind "by a kind of intuitive impulse, unassailable to argument or authority".[17]

text: Beginning about the 1830s, Jacksonian democracy introduced a less idealistic twist to the practice of limiting terms. Rotation in office came to mean taking turns in the distribution of political prizes.[18] Rotation of nominations to the U.S. House of Representatives—the prizes—became a key element of payoffs to the party faithful. The leading lights in the local party machinery came to regard a nomination for the House as "salary" for political services rendered. A new code of political ethics evolved, based on the proposition that "turnabout is fair play".[19] In short, rotation of nominations was intertwined with the spoils system.

text: In district nominating conventions local leaders could negotiate and enforce agreements to pass the nominations around among themselves. Abraham Lincoln was elected to the United States House of Representatives in 1846 under such a bargain, and he returned home to Springfield after a single congressional term because, he wrote, "to enter myself as a competitor of another, or to authorize anyone so to enter me, is what my word and honor forbid".[20]

text: During the Civil War, the Confederate States Constitution limited its president to a single six-year term.

text: Era of incumbency[edit]

text: The practice of nomination rotation for the House of Representatives began to decline after the Civil War. It took a generation or so before the direct primary system, civil service reforms, and the ethic of professionalism worked to eliminate rotation in office as a common political practice. By the turn of the 20th century the era of incumbency was coming into full swing.

text: A total of 8 presidents served two full terms and declined a third and three presidents served one full term and refused a second. After World War II, however, an officeholder class had developed to the point that congressional tenure rivaled that of the U.S. Supreme Court, where tenure is for life.

text: Term limits movement[edit]

text: "Homesteading," or securing a lifelong career in Congress, was made possible by reelection rates that approached 100% by the end of the 20th century. The concept of homesteading brought about a popular movement known as the "term-limits movement". The elections of 1990–94 saw the adoption of term limits for state legislatures in almost every state where citizens had the power of the initiative. In addition, 23 states limited service in their delegation to Congress. As they pertain to Congress, these laws are no longer enforceable, however, as in 1995, the U.S. Supreme Court overturned congressional term limits in U.S. Term Limits, Inc. v. Thornton, ruling that state governments cannot limit the terms of members of the national government.[21]

text: Where rotation in the legislative branch has withstood court challenges, term limits continue to garner popular support. As of 2002, the advocacy group "U.S. Term Limits" found that in the 17 states where state legislators served in rotation, public support for term limits ranged from 60 to 78 percent.[22]

text: Federal term limits[edit]

text:
Office
Term limits

President

Limited to being elected to a total of 2 four-year terms. A President by succession who completes more than two years of a former President's unfinished term may be elected in his or her own right only once, and 2 more four-year terms are permitted if they complete two years or less. Becoming a President by succession may happen to someone an unlimited number of times, for example, if he or she is Vice President and the President dies, resigns or is removed from office via impeachment conviction.[23][24]

Vice President

Unlimited four-year terms

House of Representatives

Unlimited two-year terms

Senate

Unlimited six-year terms

Supreme Court

No term limits, appointed to serve "during good behavior"[25] (but can be impeached and removed from office for "high Crimes and Misdemeanors"); in practice a Justice serves until death or stepping down (by retirement or resignation)

text: As of 2013, term limits at the federal level are restricted to the executive branch and some agencies. Judicial appointments at the federal level are made for life, and are not subject to election or to term limits. The U.S. Congress remains (since the Thornton decision of 1995) without electoral limits.

text: President[edit]

text: The first U.S. president, George Washington, started the tradition of informal presidential term limits by refusing to run for a third term (originally he claimed he did not want to run in the first place, much less for a second term). The short-lived Confederate States of America adopted a six-year term for their president and vice-president and barred the president from seeking re-election. That innovation was endorsed by many American politicians after the  American Civil War, most notably by Rutherford B. Hayes in his inaugural address.

text: Franklin D. Roosevelt (president, 1933–1945) was the first and only U.S. president to break Washington's tradition successfully. He died in office a few months after starting his fourth term. This gave rise to a successful move in Congress to formalize the traditional two-term limit by amending the U.S. Constitution. As ratified in 1951, the Twenty-Second Amendment provides that "no person shall be elected to the office of President more than twice".

text: Congress[edit]

text: Reformers during the early 1990s used the initiative and referendum to put congressional term limits on the ballot in 24 states. Voters in eight of these states approved the congressional term limits by an average electoral margin of two to one.[26] It was an open question whether states had the constitutional authority to enact these limits. In May 1995, the U.S. Supreme Court ruled 5–4 in U.S. Term Limits, Inc. v. Thornton, 514 U.S. 779 (1995), that states cannot impose term limits upon their federal Representatives or Senators.

text: In the 1994 elections, part of the Republican platform included legislation for term limits in Congress. After winning the majority, a Republican congressman brought a constitutional amendment to the House floor that proposed limiting members of the Senate to two six-year terms and members of the House to six two-year terms.[27] However, this rate of rotation was so slow (the life-tenured Supreme Court averages in the vicinity of twelve years) that the congressional version of term-limits garnered little support among the populist backers of term limits, including U.S. Term Limits, the largest private organization pushing for congressional term limits.[28][citation needed] The bill got only a bare majority (227–204), falling short of the two-thirds majority (290) needed for constitutional amendments.[29] Three other term limit amendment bills failed to get more than 200 votes.[30]

text: Defeated in Congress and overridden by the Supreme Court, the federal term limit uprising was brought to a halt. The term limits intended simultaneously to reform state legislatures (as distinguished from the federal congressional delegations) remain in force, however, in fifteen states.[31][32]

text: In 2007 Larry J. Sabato revived the debate over term limits by arguing in A More Perfect Constitution that the success and popularity of term limits at the state level suggests that they should be adopted at the federal level as well. He specifically put forth the idea of congressional term limits and suggested a national constitutional convention be used to accomplish the amendment, since the Congress would be unlikely to propose and adopt any amendment that limits its own power.

text: Some state legislators have also expressed their opinions on term limits. It is confirmed that in the following five states—and there may be others—state lawmakers approved resolutions asking Congress to propose a federal constitutional amendment to limit the number of terms which members of Congress may serve:

text: This section has an unclear citation style. The references used may be made clearer with a different or consistent style of citation and footnoting. (February 2017) (Learn how and when to remove this template message)

text:
South Dakota Legislature (designated as POM-42 in the U.S. Senate) approved in 1989, South Dakota House Joint Resolution No. 1001 (see Congressional Record of April 4, 1989, at pages 5395 and 5396, with verbatim text provided);
Hawaii Senate (designated as Memorial 400 in the U.S. House of Representatives) approved in 1990, Hawaii Senate Resolution No. 41—unicameral only (see Congressional Record of September 28, 1998, at page 22655) it took 8 years for this resolution to find its way into the Congressional Record and to be correctly referred to the Committee on the Judiciary—and even then, its text was not provided in the Congressional Record); back in 1990, Hawaii's S.R. No. 41 was indeed received by the U.S. House of Representatives, and was designated as Memorial 416, (Congressional Record of June 6, 1990, at pages 13262 and 13263) but the resolution was erroneously referred to the Committee on Energy and Commerce—and its text is NOT provided in the Congressional Record;
Utah Legislature (designated as POM-644 in the U.S. Senate) approved in 1990, Utah Senate Joint Resolution No. 24 (see Congressional Record of September 27, 1994, at page 26033, with verbatim text provided) it took four years for this resolution to find its way into the U.S. Senate's portion of the Congressional Record;
Idaho Legislature (designated as Memorial 401 in the U.S. House of Representatives) approved in 1992, Idaho Senate Joint Memorial No. 116 (see Congressional Record of April 29, 1992, at page 9804—text NOT provided in the Congressional Record); and
Florida Legislature (designated as POM-122 in the U.S. Senate) approved in 2012, Florida House Memorial No. 83 (see Congressional Record of July 25, 2012, at page S5378, with verbatim text provided).  Taking matters a bit further, on February 10, 2016, Florida lawmakers approved House Memorial No. 417 calling upon Congress, pursuant to Article V of the Federal Constitution, to assemble a Convention to prepare a constitutional amendment that would establish term limits upon members of Congress.

text: Supreme Court[edit]

text: Legal scholars have discussed whether or not to impose term limits on the Supreme Court of the United States. Currently, Supreme Court Justices are appointed for life "during good behavior". A sentiment has developed, among certain scholars, that the Supreme Court may not be accountable in a way that is most in line with the spirit of checks and balances.[33] Equally, scholars have argued that life tenure has taken on a new meaning in a modern context.[34] Changes in medical care have markedly raised life expectancy and therefore has allowed Justices to serve for longer than ever before.[33][34] Steven G. Calebresi and James Lindgren, professors of law at Northwestern University, argued that, because vacancies in the court are occurring with less frequency and justices served on average, between 1971 and 2006, for 26.1 years, the "efficacy of the democratic check that the appointment process provides on the Court's membership" is reduced.[33] There have been several similar proposals to implement term limits for the nation's highest court, including Professor of Law at Duke University, Paul Carrington's 2005 "The Supreme Court Renewal Act of 2005".[35]

text: Many of the proposals center around a term limit for Justices that would be 18 years (Larry Sabato, Professor of Political Science at University of Virginia, suggested between 15 and 18 years).[33][34][35][36] The proposed staggered term limits of 18 years would, according to Calebresi, Lindgren (2006), and Carrington (2005), allow for a new appointment to the Court every two years, which in effect would allow every president at least two appointments.[34][35] Professor Carrington has argued that such a measure would not require a constitutional amendment as the "Constitution doesn’t even mention life tenure; it merely requires that justices serve during ‘good behaviour’ ".[34] The idea was not without support among Judges, as John Roberts supported term limits before he was appointed to the Supreme Court as Chief Justice. Calebresi, Lingren, and Carrington have also proposed that when justices have served out their proposed 18-year term they should be able to sit on other Federal Courts until retirement, death, or removal.[33][34]

text: Fairleigh Dickinson University's PublicMind Poll measured American voters’ attitudes towards various proposed Supreme Court reforms, including implementing term limits. The 2010 poll found that a majority of Americans were largely unaware of a proposal to impose a term limit of 18 years, as 82% reported they had heard little or nothing at all.[37] Notwithstanding a lack of awareness, 52% of Americans approved of limiting terms to 18 years, while 35% disapproved.[37] When asked how old is too old for a Supreme Court judge to serve if he or she seems healthy, 48% said "no limit as long as he or she is healthy", while 31% agreed that anyone over the age of 70 is too old.[37]

text: Some state lawmakers have officially expressed to Congress a desire for a federal constitutional amendment to limit terms of Supreme Court justices as well as of judges of federal courts below the Supreme Court level. While there might be others, below are three known examples:

text:
In 1957, the Alabama Legislature adopted Senate Joint Resolution No. 47 on the subject (appearing in the U.S. Senate's portion of the Congressional Record on July 3, 1957, at page 10863, with full text provided);
In 1978, the Tennessee General Assembly adopted House Joint Resolution No. 21 on the subject (designated as POM-612 by the U.S. Senate and quoted in full in the Congressional Record of April 25, 1978, at page 11437); and
In 1998, the Louisiana House of Representatives adopted House Resolution No. 120 on the subject (designated as POM-511 by the U.S. Senate and quoted in full in the Congressional Record of July 17, 1998, at page 16076).

text: State term limits[edit]

text: Term limits for state officials have existed since colonial times. The Pennsylvania Charter of Liberties of 1682, and the colonial frame of government of the same year, both authored by William Penn, provided for triennial rotation of the provincial council—the upper house of the colonial legislature.[38] The Delaware Constitution of 1776 limited the governor to a single three-year term; currently, the governor of Delaware can serve two four-year terms.

text: At present, 36 states have term limits of various types for their governors. To circumvent the term limit in Alabama incumbent governor George Wallace pushed through the nomination of his wife Lurleen, in the 1966 Democratic primary, which was, in those days, the real contest in Alabama. It was generally understood that Mrs. Wallace would only be a titular governor while her husband continued to hold the real power. She won the election, but only served 16 months before dying in 1968.

text: As indicated above, in fifteen state legislatures the members serve in rotation, i.e., under term limits enacted during the reforms of the early 1990s. In another six states, however, state legislatures have either overturned their own limits or state supreme courts have ruled such limits unconstitutional. In 2002 the Idaho Legislature became the first legislature of its kind to repeal its own term limits, enacted by a public vote in 1994, ostensibly because it applied to local officials along with the legislature.

text: Gubernatorial term limits[edit]

text: No limit   No limit, two-year terms   One; reeligible after four years     Two; reeligible after four years   Two; eligible 8 out of 12 years   Two; eligible 8 out of 16 years   Two, absolute

text: Governors of 36 states and four territories are subject to various term limits, while the governors of 14 states, Puerto Rico, and the Mayor of Washington, D.C., may serve an unlimited number of terms. Each state's gubernatorial term limits are prescribed by its state constitution, with the exception of Wyoming, whose limits are found in its statutes. Territorial term limits are prescribed by its constitution in the Northern Mariana Islands, the Organic Acts in Guam and the U.S. Virgin Islands, and by statute in American Samoa.

text: Unique in its restriction, Virginia prohibits its governors from succeeding themselves for a second term, although former governors are reeligible after four years out of office.[39] Many other states formerly had this prohibition, but all had eliminated it by 2000.

text: The governors of the following states and territories are limited to two consecutive terms, but are reeligible after four years out of office: Alabama,[40] Alaska,[41] Arizona,[42] Colorado,[43] Florida,[44] Georgia,[45] Hawaii,[46] Kansas,[47] Kentucky,[48] Louisiana,[49] Maine,[50] Maryland,[51] Nebraska,[52] New Jersey,[53] New Mexico,[54] North Carolina,[55] Ohio,[56] Pennsylvania,[57] Rhode Island,[58] South Carolina,[59] South Dakota,[60] Tennessee,[61] West Virginia,[62] American Samoa,[63] Guam,[64] and the U.S. Virgin Islands.[65] Equivalently, the Governors of Indiana[66] and Oregon[67] are limited to serving 8 out of any 12 years. Conversely, the Governors of Montana[68] and Wyoming[69] are restricted to two terms, limited to serving 8 out of any 16 years. Finally, the governors of the following states and territory are absolutely limited (for life) to two terms: Arkansas,[70] California,[71] Delaware,[72] Michigan,[73] Mississippi,[74] Missouri,[75] Nevada,[76] the Northern Mariana Islands,[77] and Oklahoma.[78] The current Governor of California (Jerry Brown) is, however, serving a fourth (non-consecutive) term because his first two terms were before limits were passed in California, and the limits did not apply to individuals' prior terms.

text: The governors of New Hampshire and Vermont may serve unlimited two-year terms. The governors (or equivalent) in the following states, district, and territory may serve unlimited four-year terms: Connecticut, Idaho, Illinois, Iowa, Massachusetts, Minnesota, New York, North Dakota, Texas, Utah, Washington, Wisconsin, District of Columbia, and Puerto Rico. The Governor of Utah was previously limited to serving three terms, but all term limit laws have since been repealed by the legislature.

text: State legislatures with term limits[edit]

text: The following 15 legislatures have term limits:

text:
Arizona Legislature: four consecutive two-year terms for both houses (eight years). No limit on total number of terms.
Arkansas General Assembly: sixteen years total in either the House or the Senate. (Prior to the 2014 election, the previous limits of three two-year terms for House members (six years) and two four-year terms for Senate members (eight years) applied).
California State Legislature: twelve years total in either Assembly or Senate. (For legislators first elected on or before June 5, 2012, the previous limits (enacted in 1990) of either three two-year terms for Assembly members (six years) and two four-year terms for Senate members (eight years) apply).
Colorado General Assembly: four consecutive two-year terms in the House (eight years) and two consecutive four-year terms in the Senate (eight years).
Florida Legislature: may serve no more than eight consecutive years in either house. No limit on total number of terms.
Louisiana State Legislature: three consecutive four-year terms for both houses (twelve years). Members may run for the opposite body without having to sit out an election.
Maine Legislature: four two-year terms for both houses (eight years). No limit on total number of terms
Michigan Legislature: three two-year terms for House members (six years) and two four-year terms for Senate members (eight years).
Missouri General Assembly: four consecutive two-year terms for House members (eight years) and two four-year consecutive terms for Senate members (eight years). Members may be elected again to the other house, but not serve more than 16 years.
Montana State Legislature: four two-year terms for House members (eight years) in any sixteen-year period and two four-year terms for Senate members (eight years) in any sixteen-year period.
Nebraska Legislature: unicameral legislature; members limited to two consecutive four-year terms (eight years), after which they must wait four years before running again.[79]
Nevada Legislature: six two-year terms for Assembly members (twelve years) and three four-year terms for Senate members (twelve years).
Ohio General Assembly: four consecutive two-year terms for House members (eight years) and two consecutive four-year terms for Senate members (eight years).
Oklahoma Legislature: six two-year terms for House members (twelve years) and three four-year terms for Senate members (twelve years). Once term-limited in one house, a legislator cannot be elected to the other.
South Dakota Legislature: four consecutive two-year terms for both houses (eight years).

text: Overturned or repealed state legislative term limits[edit]

text: The following six legislatures have had their term limits nullified:

text:
Idaho Legislature: the Legislature repealed its own term limits in 2002.
Massachusetts General Court: the Massachusetts Supreme Judicial Court overturned term limits in 1997.
Oregon Legislative Assembly: the Oregon Supreme Court ruled term limits unconstitutional in 2002. See term limits in Oregon.
Utah State Legislature: the Legislature repealed its own term limits in 2003.
Washington State Legislature: the Washington Supreme Court voided term limits in 1998.
Wyoming Legislature: the Wyoming Supreme Court ruled term limits unconstitutional in 2004. See term limits in Wyoming.

text: Municipal term limits[edit]

text: Some local governments have term limits. In Philadelphia, the mayor cannot be elected three consecutive times, but there is no limit on how long any individual can serve as mayor. Frank Rizzo was elected mayor in 1971 and 1975; he attempted to repeal the term limit, but failed and could not run in 1979. He ran unsuccessfully for the Democratic nomination for mayor in 1983 but he lost to Wilson Goode. In 1986, he switched to the Republican Party, and ran as a Republican in the mayoral elections of 1987 and 1991.

text: Limits vary from city to city even within the same state. For example, Houston, Texas, has a limit of 2 four-year terms (prior to November 3, 2015, 3 two-year terms dating back to 1991), while San Antonio, Texas, has a limit of 4 two-year terms. Both Houston and San Antonio's term limits are absolute; elected officeholders are ineligible to run for the same position where seeking higher office is common.

text: A two-term limit was imposed on New York City Council members and citywide elected officials (except for district attorneys) in New York City after a 1993 referendum (see the Charter of the City of New York, § 1138). On November 3, 2008, however, when Michael Bloomberg was in his second term of mayor, the City Council approved the extension of the two-term limit to a three-term limit; one year later, he was elected to a third term. The two-term limit was reinstated after a referendum in 2010.[80][81]

text: In Los Angeles the mayor serves up to two four-year terms since 1993, while the City Council serve up to three four-year terms.

text: In Cincinnati, Ohio, the term limit for mayor is two successive four-year terms. Council members are limited to two successive four-year terms. There is no limit to total terms that may be served, just a limit on successive terms.

text: In New Orleans, City Council members are limited to two four-year terms. However, a council member representing one of the five council districts may run for one of the two at-large seats on the council once they reach the two-term limit, and vice versa. There is no limit on the number of terms a council member may serve in a lifetime. Since 1954, the mayor of New Orleans has been limited to two consecutive four-year elected terms, but he or she may be elected again after sitting out one four-year term. When the new city plan of government was adopted, the mayor at the time, DeLesseps Story Morrison, was exempt from term limits due to a grandfather clause.

text: Under the original Metropolitan Charter adopted in 1962, the mayor of Nashville was limited to three consecutive four-year terms, which was subsequently reduced to two consecutive four-year terms in 1991.  Councilors were likewise limited to two consecutive four-year terms, but subsequent court rulings have determined the offices of district councilor and at-large councilor to be separate offices even though all councilors serve together in one unicameral body, which has meant that at large councilors have continued in office as district members, and (more frequently) district councilors have been elected to subsequent terms as at large councilors.


document_title: Orange Is the New Black

question_text: when did orange is the new black season 4 start

root

text: Orange Is the New Black

text: Plot[edit]

text:
Season
Episodes
Originally released

1
13
July 11, 2013 (2013-07-11)

2
13
June 6, 2014 (2014-06-06)

3
13
June 11, 2015 (2015-06-11)

4
13
June 17, 2016 (2016-06-17)

5
13
June 9, 2017 (2017-06-09)

tag: table

text: The series revolves around Piper Chapman (Taylor Schilling), a woman in her 30s living in New York City who is sentenced to 15 months in Litchfield Penitentiary, a minimum-security women's federal prison (initially operated by the "Federal Department of Corrections," a fictional version of the Federal Bureau of Prisons, and later acquired by Management & Correction Corporation (MCC), a private prison company) in upstate New York. Piper had been convicted of transporting a suitcase full of drug money for her girlfriend Alex Vause (Laura Prepon), an international drug smuggler. The offense had occurred 10 years prior to the start of the series and in that time Piper had moved on to a quiet, law-abiding life among New York's upper middle class. Her sudden and unexpected indictment severely disrupted her relationships with her fiancé, family and friends.

tag: p

text: In prison, Piper is reunited with Alex (who named Piper in her trial, resulting in Piper's arrest) and they re-examine their relationship. Simultaneously, Piper must learn how to survive in prison and how to overcome its numerous, inherent struggles. Episodes often feature flashbacks of significant events from various inmates' and prison guards' pasts. These flashbacks typically explain how the inmate came to be in prison or develop the character's backstory.

text: The show pays close attention to how corruption, drug smuggling, funding cuts, overcrowding and guard brutality affect the prisoners' health and well-being and the prison's basic ability to fulfil its fundamental responsibilities and ethical obligations as a federal corrections institution. One of the show's key conflicts involves the prison Director of Human Activities, Joe Caputo, whose efforts and aims as a warden constantly conflict with the business interests of MCC, which acquired the facility when it was about to be shut down.

text: Cast and characters[edit]

text: Main cast[edit]

text:
Taylor Schilling as Piper Chapman, inmate
Laura Prepon as Alex Vause, inmate
Michael Harney as Sam Healy, correctional officer[a]
Michelle Hurst as Miss Claudette Pelage, inmate (season 1)
Kate Mulgrew as Galina "Red" Reznikov, inmate
Jason Biggs as Larry Bloom, Piper's fiancé (season 1–2, guest season 5)
Uzo Aduba as Suzanne "Crazy Eyes" Warren, inmate
Danielle Brooks as Tasha "Taystee" Jefferson, inmate
Natasha Lyonne as Nicky Nichols, inmate
Taryn Manning as Tiffany "Pennsatucky" Doggett, inmate
Selenis Leyva as Gloria Mendoza, inmate
Adrienne C. Moore as Cindy "Black Cindy" Hayes, inmate
Dascha Polanco as Dayanara "Daya" Diaz, inmate
Nick Sandow as Joe Caputo, Director of Human Activities, later Warden
Yael Stone as Lorna Morello, inmate
Samira Wiley as Poussey Washington, inmate (seasons 1–4, guest season 5)
Jackie Cruz as Marisol "Flaca" Gonzales, inmate
Lea DeLaria as Carrie "Big Boo" Black, inmate
Elizabeth Rodriguez as Aleida Diaz, former inmate
Jessica Pimentel as Maria Ruiz, inmate

tag: ul

text: Recurring cast[edit]

text: Inmates[edit]

text:
Laverne Cox as Sophia Burset
Annie Golden as Norma Romano
Laura Gómez as Blanca Flores
Diane Guerrero as Maritza Ramos
Vicky Jeudy as Janae Watson
Julie Lake as Angie Rice
Emma Myles as Leanne Taylor
Abigail Savage as Gina Murphy
Constance Shulman as Erica "Yoga" Jones
Lori Tan Chinn as Mei Chang
Tamara Torres as Gerrman "Weeping Woman"
Lin Tucci as Anita DeMarco
Beth Fowler as Sister Jane Ingalls (seasons 1-4)
Barbara Rosenblat as Rosa "Miss Rosa" Cisneros (seasons 1–2, guest season 3)
Madeline Brewer as Tricia Miller (season 1)
Kimiko Glenn as Brook Soso (season 2–present)
Dale Soules as Frieda Berlin (season 2–present)
Lori Petty as Lolly Whitehill (seasons 2–4)
Lorraine Toussaint as Yvonne "Vee" Parker (season 2)
Emily Althaus as Maureen Kukudio (season 3–present)
Blair Brown as Judy King (season 3–present)
Ruby Rose as Stella Carlin (seasons 3–4)
Rosal Colon as Carmen "Ouija" Aziza (season 4–present)
Francesca Curran as Helen Van Maele (season 4–present)
Daniella De Jesus as "Zirconia" Cabrera (season 4–present)
Asia Kate Dillon as Brandy Epps (season 4–present)
Shannon Esper as Alana Dwight (season 4–present)
Arianda Fernandez as Michelle Carreras (season 4–present)
Kelly Karbacz as Kasey Sankey (season 4–present)
Miriam Morales as Ramona "Pidge" Contreras (season 4–present)
Jolene Purdy as Stephanie Hapakuka (season 4–present)
Amanda Stephen as Alison Abdullah (season 4–present)

text: Staff

text:
Catherine Curtin as Wanda Bell
Joel Marsh Garland as Scott O'Neill
Matt Peters as Joel Luschek
Alysia Reiner as Natalie "Fig" Figueroa
Brendan Burke as Wade Donaldson (seasons 1-4)
Lolita Foster as Eliqua Maxwell (seasons 1–3)
Germar Terrell Gardner as Charles Ford (seasons 1–3)
Matt McGorry as John Bennett (seasons 1–3)
Pablo Schreiber as George "Pornstache" Mendez (seasons 1–3, guest season 5)
Lauren Lapkus as Susan Fischer (seasons 1–2)
Alan Aisenberg as Baxter "Gerber" Bayley (season 3–present)
Beth Dover as Linda Ferguson / "Amelia Von Barlow" (season 3–present)
Jimmy Gary Jr. as Felix Rikerson (season 3–present)
James McMenamin as Charlie "Donuts" Coates (season 3–present)
Mike Birbiglia as Danny Pearson (seasons 3-4)
Marsha Stephanie Blake as Berdie Rogers (season 3)
Nick Dillenburg as Ryder Blake (season 4–present)
Evan Arthur Hall as Stratman (season 4–present)
Mike Houston as Lee Dixon (season 4–present)
Brad William Henke as Desi Piscatella (seasons 4–5)
John Palladino as Josh (season 4–present)
Emily Tarver as Artesian McCullough (season 4–present)
Michael Torpey as Thomas "Humps" Humphrey (seasons 4–5)

text: Others

text:
Michael Chernus as Cal Chapman (seasons 1–4)
Tanya Wright as Crystal Burset (seasons 1–4)
Tracee Chimo as Neri Feldman (seasons 1–3)
Berto Colon as Cesar (seasons 1–3, 5)
Deborah Rush as Carol Chapman (seasons 1–3, 5)
Maria Dizzia as Polly Harper (seasons 1–2)
Ian Paola as Yadriel (season 2–present)
John Magaro as Vince Muccio (season 3–present)
Mary Steenburgen as Delia Powell-Mendez (season 3, guest season 5)

text: Production[edit]

text: Show creator Jenji Kohan read Piper Kerman's memoir after a friend sent it to her. She then set up a meeting with Kerman to pitch her on a TV adaptation, which she notes she "screwed up" as she spent most of the time asking Kerman about her experiences she described in the book rather than selling her on the show. This appealed to Kerman as it let her know that she was a fan and she signed off on the adaptation.[9] Kohan would later go on to describe the main character, Piper Chapman, as a "trojan horse" for the series, allowing it to focus on characters whose demographics would not normally be represented on TV.[10]

text: In July 2011, it was revealed that Netflix was in negotiations with Lionsgate for a 13-episode TV adaptation of Kerman's memoirs with Kohan as creator.[11] In November 2011, negotiations were finalized and the series had been greenlit.[12] Casting announcements began in August 2012 with Taylor Schilling, the first to be cast, in the lead role as Piper Chapman,[13] followed by Jason Biggs as Piper's fiancé Larry Bloom.[14]

text: Laura Prepon and Yael Stone were next to join the series.[2] Abigail Savage, who plays Gina, and Alysia Reiner, who plays Fig, had auditioned for role of Alex Vause.[9][15] Prepon initially auditioned for Piper Chapman,[16] however Kohan felt she would not worry about her [in prison], noting a "toughness and a presence to her that wasn’t right for the character." Kohan instead gave her the role of Alex.[9] Stone had originally auditioned for the role of Nicky Nichols, but she was not considered "tough enough" for the character;[17] she was asked to audition for Lorna Morello instead.[18] Likability was important for Morello, whom casting director Jen Euston deemed "a very helpful, nice, sweet Italian girl."[18] Laverne Cox, a black transgender woman, was cast as Sophia Burset, a transgender character. The Advocate touted Orange Is the New Black as possibly the first women-in-prison narrative to cast a transgender woman for this type of role.[19] Natasha Lyonne was to audition for Alex, but was asked to read for the character Nicky Nichols; "[Kohan knew] she could do Nicky with her eyes closed. She was perfect," said Euston.[18] Uzo Aduba read for the part of Janae Watson but was offered the character Suzanne "Crazy Eyes" Warren.[18][20] Taryn Manning was offered the role of Tiffany "Pennsatucky" Doggett.[18] This American Life host Ira Glass was offered a role as a public radio host, but he declined. The role instead went to Robert Stanton, who plays the fictional host Maury Kind.[21]

text: The series is set in a fictional prison in Litchfield, New York, which is a real town in upstate New York, but it does not have a federal penitentiary.[22] The series began filming in the old Rockland Children's Psychiatric Center in Rockland County, New York, on March 7, 2013.[23] The title sequence features photos of real former female prisoners including Kerman herself.[24]

text: On June 27, 2013, prior to the series premiere, Netflix renewed the show for a second season consisting of 13 episodes.[25] For the second season, Uzo Aduba, Taryn Manning, Danielle Brooks, and Natasha Lyonne were promoted to series regulars.[26] Laura Prepon did not return as a series regular for a second season because of scheduling conflicts, but returned for season 3 as a regular.[27] On May 5, 2014, the series was renewed for a third season, as revealed by actress Laura Prepon.[28] For the third season, several actors were promoted to series regulars, including Selenis Leyva, Adrienne C. Moore, Dascha Polanco, Nick Sandow, Yael Stone, and Samira Wiley.[29] Both Jason Biggs and Pablo Schreiber were confirmed as not returning for the third season, but Schreiber appeared in the 10th episode of the third season.[30][31][32] The series was renewed for a fourth season on April 15, 2015, prior to its third-season premiere.[33][34] For the fourth season, Jackie Cruz and Lea DeLaria were promoted to series regulars; with Elizabeth Rodriguez also being promoted by the season's sixth episode.[35] On February 5, 2016, the series was renewed for a fifth, sixth and seventh season.[4]

text: Reception[edit]

text: Critical response[edit]

text:
Season
Critical response

Rotten Tomatoes
Metacritic

1
93% (40 reviews)
79 (32 reviews)

2
98% (42 reviews)
89 (31 reviews)

3
96% (24 reviews)
83 (53 reviews)

4
95% (39 reviews)
86 (19 reviews)

5
74% (35 reviews)
67 (20 reviews)

text: Orange Is the New Black has received critical acclaim, particularly praised for humanizing prisoners[36][37] and for its depiction of race, sexuality, gender and body types.[38]

text: The first season received positive reviews from critics, review aggregator Metacritic gave it a weighted average score of 79 out of 100 based on reviews from 32 critics, indicating favorable reviews.[39] On Rotten Tomatoes, season one has a 93% approval rating based on 40 reviews, with an average rating of 8.2 out of 10 . The site's critical consensus is "Orange Is the New Black is a sharp mix of black humor and dramatic heft, with interesting characters and an intriguing flashback structure."[40]

text: Hank Stuever, television critic for The Washington Post, gave Orange Is the New Black a perfect score. In his review of the series, he stated: "In Jenji Kohan's magnificent and thoroughly engrossing new series, Orange Is the New Black, prison is still the pits. But it is also filled with the entire range of human emotion and stories, all of which are brought vividly to life in a world where a stick of gum could ignite either a romance or a death threat."[41] Maureen Ryan, of The Huffington Post, wrote: "Orange is one of the best new programs of the year, and the six episodes I've seen have left me hungry to see more."[42]

text: The second season also received critical acclaim. Rotten Tomatoes gave a rating of 98%, with an average rating of 9.1 out of 10 based on 42 reviews. The site's critical consensus reads: "With a talented ensemble cast bringing life to a fresh round of serial drama, Orange Is the New Black's sophomore season lives up to its predecessor's standard for female-led television excellence.[43] Metacritic gave the second season a score of 89 out of 100 based on 31 critics, indicating "universal acclaim."[44] David Wiegland of the San Francisco Chronicle gave the season a positive review, calling the first six episodes "not only as great as the first season, but arguably better."[45]

text: The third season received critical acclaim. On Metacritic, it has a score of 83 out of 100 based on 24 reviews.[46] On Rotten Tomatoes, it has a 96% rating with an average score of 8.2 out of 10 based on 53 reviews. The site's critical consensus reads: "Thanks to its blend of potent comedy and rich character work, Orange is the New Black remains a bittersweet pleasure in its third season."[47]

text: The fourth season received critical acclaim. On Metacritic, it has a score of 86 out of 100 based on 19 reviews.[48] On Rotten Tomatoes, it has a 95% rating with an average score of 8.6 out of 10 based on 39 reviews. The site's critical consensus reads: "Orange is the New Black is back and better than ever, with a powerful fourth season full of compelling performances by the ensemble cast."[49] James Poniewozik of The New York Times reviewed the fourth season as "Do you measure the quality of a TV season as a beginning-to-end average or by how well it ends? By the first yardstick, Season 4 is ambitious but uneven; by the latter, it's the series' best."[50]

text: The fifth season has received "generally favorable reviews".[51] On Metacritic, it has a score of 67 out of 100 based on 20 reviews.[51] On Rotten Tomatoes, it has a 76% rating with an average score of 7.47 out of 10 based on 33 reviews.[52]

text: Accolades[edit]

text: Orange Is the New Black has received many accolades since its debut. The series has garnered 16 Emmy Award nominations and four wins. For its first season, it received 12 Emmy Award nominations, including Outstanding Comedy Series, Outstanding Writing for a Comedy Series, and Outstanding Directing for a Comedy Series, winning three.[53] Taylor Schilling received a Golden Globe Award nomination for Best Actress in a Television Series – Drama.[54] In 2013, the American Film Institute selected the series as one of the Top 10 Television Programs of the Year.[55]

text: A new Emmy rule in 2015, classifying half-hour shows as comedies and hour-long shows as dramas, forced the series to change categories from comedy to drama for its second season.[56] That year, the series received four Emmy nominations, including Outstanding Drama Series, and Aduba won her second Emmy Award, for Outstanding Supporting Actress in a Drama Series.[53] Orange Is the New Black became the first series to receive Emmy nominations in both comedy and drama categories.[8] For its second season, the series also received three Golden Globe Award nominations: Best Television Series – Musical or Comedy, Best Actress – Television Series Musical or Comedy for Schilling, and Best Supporting Actress – Series, Miniseries or Television Film for Aduba. At the 21st Screen Actors Guild Awards, the series won Outstanding Performance by an Ensemble in a Comedy Series and Aduba won Outstanding Performance by a Female Actor in a Comedy Series.[57]

text: For its third season, Orange Is the New Black won Screen Actors Guild Awards for Outstanding Performance by an Ensemble in a Comedy Series and Outstanding Performance by a Female Actor in a Comedy Series (Aduba).[58] It received a Golden Globe Award nomination for Best Television Series – Musical or Comedy.[54] The series has also received, among other accolades, six Writers Guild of America Award nominations,[59] five Satellite Awards,[60][61] four Critics' Choice Television Awards,[62][63] a GLAAD Media Award,[64] an American Cinema Editors Award,[65] a Producers Guild of America Award,[66] and a Peabody Award.[67]

text: Broadcast[edit]

text:
Netflix is famously tight-fisted when it comes to offering up viewership data about its original series. But execs with the streaming giant have repeatedly confirmed that OITNB is its most-watched original series. That has been backed up by the efforts of outside measurement companies to track viewing in the Netflix eco-system.

—Variety[4]

tag: div

text: The series began airing on broadcast television in New Zealand on TV2 on August 19, 2013.[68] It premiered in Australia on October 9, 2013, on Showcase.[69] The second season began on Showcase on July 16, 2014,[70] and the third season premiered on June 11, 2015.[71] The first season began airing on broadcast television in the UK on Sony Channel from April 19, 2017.[72]

text: In April 2017, it was reported that a cybercriminal had stolen the first ten episodes of the fifth season in a security breach of a post-production company. Netflix failed to respond to ransom demands, and the cybercriminal leaked the episodes online. Netflix confirmed the security breach and an ongoing investigation by federal law enforcement.[73][74] Multichannel News reported that demand for the series significantly increased over the seven-day period following the leak of the episodes. It was also said that the leak would likely cause a decrease in demand for the fifth season when Netflix releases it in June.[75]

text: Ratings[edit]

text: Orange Is the New Black generated more viewers and hours viewed in its first week than the other Netflix original series House of Cards and Arrested Development.[76][77] In October 2013, Netflix stated that the show is a "tremendous success" for the streaming platform. "It will end the year as our most watched original series ever and, as with each of our other previously launched originals, enjoys an audience comparable with successful shows on cable and broadcast TV."[78][79] As reported in February 2016, Orange Is the New Black remains Netflix's most-watched original series.[4][6][80] In 2016, a New York Times study of the 50 TV shows with the most Facebook Likes found that Orange Is the New Black is one of the shows most watched in urban areas, and despite its "minority-rich ensemble cast," the series "appeals more to a white audience."[81]

text: Notes[edit]

text: Jump up ^ Michael J. Harney was credited as main cast for season 5 but did not make a single appearance.

tag: ol


document_title: Wind speed

question_text: when do the highest surface wind speeds occur

text: Wind speed

text: Factors affecting wind speed[edit]

text: Wind speed is affected by a number of factors and situations, operating on varying scales (from micro to macro scales). These include the pressure gradient, Rossby waves and jet streams, and local weather conditions. There are also links to be found between wind speed and wind direction, notably with the pressure gradient and terrain conditions.

text: Pressure gradient is a term to describe the difference in air pressure between two points in the atmosphere or on the surface of the Earth. It is vital to wind speed, because the greater the difference in pressure, the faster the wind flows (from the high to low pressure) to balance out the variation. The pressure gradient, when combined with the Coriolis effect and friction, also influences wind direction.

text: Rossby waves are strong winds in the upper troposphere. These operate on a global scale and move from West to East (hence being known as Westerlies). The Rossby waves are themselves a different wind speed from what we experience in the lower troposphere.

text: Local weather conditions play a key role in influencing wind speed, as the formation of hurricanes, monsoons and cyclones as freak weather conditions can drastically affect the flow velocity of the wind.

text: Highest speed[edit]

text: The fastest wind speed not related to tornadoes ever recorded was during the passage of Tropical Cyclone Olivia on 10 April 1996: an automatic weather station on Barrow Island, Australia, registered a maximum wind gust of 408 km/h (220 kn; 253 mph; 113 m/s).[2] The wind gust was evaluated by the WMO Evaluation Panel who found that the anemometer was mechanically sound and the gust was within statistical probability and ratified the measurement in 2010. The anemometer was mounted 10 m above ground level (and thus 64 m above sea level). During the cyclone, several extreme gusts of greater than 300 km/h (160 kn; 83 m/s) were recorded, with a maximum 5-minute mean speed of 176 km/h (95 kn; 110 mph; 49 m/s), the extreme gust factor was in the order of 2.27–2.75 times the mean wind speed. The pattern and scales of the gusts suggest that a mesovortex was embedded in the already strong eyewall of the cyclone.[3]

text: The now second highest surface wind speed ever officially recorded is 372 km/h (231 mph; 103 m/s) at the Mount Washington (New Hampshire) Observatory: 6,288 ft (1917 m) above sea level in the US on 12 April 1934, using a heated anemometer. The anemometer, specifically designed for use on Mount Washington was later tested by the US National Weather Bureau and confirmed to be accurate.[4]

text: Wind speeds within certain atmospheric phenomena (such as tornadoes) may greatly exceed these values but have never been accurately measured. Directly measuring these tornadic winds is rarely done as the violent wind would destroy the instruments. A method of estimating speed is to use Doppler on Wheels to sense the wind speeds remotely,[5] and, using this method, the figure of 486 km/h (302 mph; 135 m/s) during the 1999 Bridge Creek–Moore tornado in Oklahoma on 3 May 1999 is often quoted as the highest-recorded surface wind speed,[6] although another figure of 512 kilometres per hour (318 mph) has also been quoted for the same tornado.[7] Yet another number used by the Center for Severe Weather Research for that measurement is 486 ± 32 km/h (302 ± 20 mph).[8] However, speeds measured by Doppler radar are not considered official records.[7]

text: Measurement[edit]

text: An anemometer is one of the tools used to measure wind speed[9]. A device consisting of a vertical pillar and 4 concave cups, the anemometer captures the horizontal movement of air particles (wind speed).

text: Another tool used to measure wind velocity includes a GPS combined with pilot tube. A fluid flow velocity tool, the pilot tube is primarily used to determine the air velocity of an aircraft.

text: Design of structures[edit]

text: Wind speed is a common factor in the design of structures and buildings around the world. It is often the governing factor in the required lateral strength of a structure's design.

text: In the United States, the wind speed used in design is often referred to as a "3-second gust" which is the highest sustained gust over a 3-second period having a probability of being exceeded per year of 1 in 50 (ASCE 7-05)[10]. This design wind speed is accepted by most building codes in the United States and often governs the lateral design of buildings and structures.

text: In Canada, reference wind pressures are used in design and are based on the "mean hourly" wind speed having a probability of being exceeded per year of 1 in 50. The reference wind pressure (q) is calculated in Pascals using the following equation (ref: NBC 2005 Structural Commentaries - Part 4 of Div. B, Comm. I): q=(1/2)pV² where p is the air density in kg/m³ and V is wind speed in m/s.

text: Historically, wind speeds have been reported with a variety of averaging times (such as fastest mile, 3-second gust, 1-minute and mean hourly) which designers may have to take into account. To convert wind speeds from one averaging time to another, the Durst Curve (Ref: ASCE 7-05 commentary Figure C6-4, ASCE 7-10 C26.5-1) was developed which defines the relation between probable maximum wind speed averaged over t seconds, Vt, and mean wind speed over one hour V3600.


document_title: Constituent Assembly of India

question_text: who was the chairman of the drafting committee of the constituent assembly

text: Constituent Assembly of India

text: Description [edit]

text: The Constituent Assembly, consisting of indirectly elected representatives, was established to draft a constitution for India (including the now-separate countries of Pakistan and Bangladesh). It existed for almost three years, the first parliament of India after independence in 1947. The Assembly was not elected on the basis of universal adult suffrage, and Muslims and Sikhs received special representation as minorities. The Muslim League boycotted the Assembly after failing to prevent its creation. Although a large part of the Constituent Assembly was drawn from the Congress Party in a one-party environment, the Congress Party included a wide diversity of opinions—from conservative industrialists and radical Marxists to Hindu revivalists—all of whom participated in the process.

text: The Assembly met for the first time in New Delhi on 9 December 1946, and its last session was held on 24 January 1950.[1] During this period (two years, eleven months and eighteen days) the Assembly held eleven sessions, sitting for a total of 166 days.[2] The hope of the Assembly was expressed by Jawaharlal Nehru:

text: The first task of this Assembly is to free India through a new constitution, to feed the starving people, and to clothe the naked masses, and to give every Indian the fullest opportunity to develop himself according to his capacity. This is certainly a great task. Look at India today. We, are sitting here and there in despair in many places, and unrest in many cities. The atmosphere is surcharged with these quarrels and feuds which are called communal disturbances, and unfortunately we sometimes cannot avoid them. But at present the greatest and most important question in India is how to solve the problem of the poor and the starving. Wherever we turn, we are confronted with this problem. If we cannot solve this problem soon, all our paper constitutions will become useless and purposeless. Keeping this aspect in view, who could suggest to us to postpone and wait?

text: Background and election[edit]

text: The Constituent Assembly was established while India was still under British rule, following negotiations between Indian leaders and members of the 1946 Cabinet Mission to India from the United Kingdom. Provincial assembly elections were held early in 1946. Constituent Assembly members were elected indirectly by members of the newly elected provincial assemblies, and initially included representatives for those provinces which formed part of Pakistan (some of which are now in Bangladesh). The Constituent Assembly had 299 representatives, including nine women.

text: The Interim Government of India was formed on 2 September 1946 from the newly elected Constituent Assembly. The Congress held a large majority in the Assembly (69 percent of the seats), and the Muslim League held nearly all the seats reserved in the Assembly for Muslims. There were also members of smaller parties, such as the Scheduled Caste Federation, the Communist Party of India and the Unionist Party.

text: In June 1947 delegations from Sindh, East Bengal, Baluchistan, West Punjab and the North West Frontier Province withdrew to form the Constituent Assembly of Pakistan, meeting in Karachi. On 15 August 1947 the Dominion of India and Dominion of Pakistan became independent nations, and members of the Constituent Assembly who had not withdrawn to Karachi became India's Parliament. Twenty-eight members of the Muslim League joined the Indian Assembly, and 93 members were later nominated from the princely states; the Congress Party secured a majority of 82 percent.

text: Constitution and elections[edit]

text: At 11 am on 9 December 1946 the Assembly began its first session, with 208 members attending.  By early 1947, representatives of the Muslim League and princely states joined, and the Assembly approved the draft constitution on 26 November 1949. On 26 January 1950 the constitution took effect (commemorated as Republic Day), and the Constituent Assembly became the Provisional Parliament of India (continuing until after the first elections under the new constitution in 1952).

text: Organization[edit]

text: Dr. Sachchidananda Sinha was the first chairman (temporary) of Constituent Assembly. Later Dr. Rajendra Prasad was elected as the president and Its vice-president was Harendra Coomar Mookerjee, a Christian from Bengal and former vice-chancellor of Calcutta University. Also chairing the assembly's Minorities Committee, Mookerjee was appointed governor of West Bengal after India became a republic. Jurist B. N. Rau was appointed constitutional adviser to the assembly; Rau prepared the original draft of the constitution, and was later appointed a judge in the Permanent Court of International Justice in The Hague.

text: The assembly's work had five stages:

text:
Committees presented reports on issues.
B.N. Rau prepared an initial draft based on the reports and his research into the constitutions of other nations.
The drafting committee, chaired by B. R. Ambedkar, presented a detailed draft constitution which was published for public discussion.
The draft constitution was discussed, and amendments proposed and enacted.
The constitution was adopted, with a committee of experts led by the Congress Party (known as the Congress Assembly Party) played a pivotal role.[3]

text: Timeline[edit]

text:
9 December 1946: The first meeting of the Constituent Assembly was held in the constitution hall (now the Central Hall of Parliament House). Demanding a separate state, the Muslim League boycotted the meeting. Sachchidananda Sinha was elected temporary president of the assembly, in accordance with French practice.
11 December 1946: Rajendra Prasad was elected as president and H. C. Mukherjee was elected as vice-president of the constituent assembly. B. N. Rau was appointed as its constitutional adviser.
13 December 1946: An 'Objective Resolution' was moved by Jawaharlal Nehru in the assembly, laying down the underlying principles of the constitution. It finally became the Preamble of the constitution.
22 January 1947: Objective resolution unanimously adopted.
22 July 1947: National flag adopted.
15 August 1947: Indian independence achieved as the Dominion of India.
29 August 1947: Drafting Committee appointed with Dr. B. R. Ambedkar as the Chairman.
16 July 1948: Along with Harendra Coomar Mookerjee V. T. Krishnamachari was also elected as second vice-president of Constituent Assembly.
26 November 1949: Constitution passed and accepted by the assembly.
24 January 1950: "Jana Gana Mana" adopted as the national anthem, with the first two verses of "Vande Mataram" the national song. Rajendra Prasad elected the first president of India.

text: The assembly was chaired by Dr. Rajendra Prasad when it met as a constituent body, and by G. V. Mavlankar when it met as a legislative body. It completed the task of drafting a constitution in two years, eleven months and eighteen days, at a total expenditure of ₹6.4 million.

text: Committees of the Constituent Assembly[edit]

text: The Constituent Assembly appointed a total of 22 committees to deal with different tasks of constitution-making. Out of these, eight were major committees and the others were minor committees.

text: Major Committees

text:
Drafting Committee – Dr. B.R. Ambedkar
Union Powers Committee – Jawaharlal Nehru
Union Constitution Committee – Jawaharlal Nehru
Provincial Constitution Committee – Sardar Patel
Advisory Committee on Fundamental Rights, Minorities and Tribal and Excluded Areas – Sardar Patel.	This committee had the following subcommittees:
Fundamental Rights Sub-Committee – J.B. Kripalani
Minorities Sub-Committee – Harendra Coomar Mookerjee,
North-East Frontier Tribal Areas and Assam Excluded & Partially Excluded Areas Sub-Committee – Gopinath Bardoloi
Excluded and Partially Excluded Areas (Other than those in Assam) Sub-Committee – A V Thakkar
Rules of Procedure Committee – Dr. Rajendra Prasad
States Committee (Committee for Negotiating with States) – Jawaharlal Nehru
Steering Committee – Dr. Rajendra Prasad

text: Prominent members[edit]

text:
B. R. Ambedkar, Minister for Law; Chairman of Drafting Committee
B. N. Rau, Constitutional Advisor
Jawaharlal Nehru, first Prime Minister of India
Sardar Vallabhbhai Patel, first Deputy Prime Minister and Home Minister
Maulana Abul Kalam Azad, Minister for Education
Rajendra Prasad, President of Constituent Assembly
C. Rajagopalachari, Governor-General of India
Sarat Chandra Bose, Barrister and Indian independence activist
Krishna Sinha, first Chief Minister, Bihar
Binodanand Jha,  Minister, Bihar
Shyam Nandan Prasad Mishra
Anugrah Narayan Sinha, Deputy Chief Minister and Finance Minister, Bihar
Rafi Ahmed Kidwai
Asaf Ali
Syama Prasad Mookerjee, Industries Minister, President, Hindu Mahasabha
Moturi Satyanarayana, Freedom Fighter
Rajkumari Amrit Kaur, Health Minister
Hansa Mehta, President, All India Women's Conference
N. G. Ranga
Deep Narayan Singh, Minister, Bihar
Gopinath Bordoloi, Prime Minister of Assam[4]
Sir Syed Muhammad Saadulla, Assam
P. Subbarayan
Kailashnath Katju
N. Gopalaswami Ayyangar
T. T. Krishnamachari
Rameshwar Prasad Sinha
Durgabai Deshmukh
K. M. Munshi
Krishana Ballabh Sahay
Frank Anthony, Anglo-Indian representative
Sarvepalli Radhakrishnan
John Mathai,first railway minister of India
Pratap Singh Kairon
L. Krishnaswamy Bharati - Madras Province
Chidambaram Subramaniam
Jaipal Singh Munda, Former Indian Hockey captain, and Tribal leader

text: Members (by province/state)[edit]

text:
Madras:
Annie Mascarene, O. V. Alagesan,
Mrs. Ammu Swaminathan,
M. Ananthasayanam Ayyangar,
Moturi Satyanarayana,
Mrs. Dakshayani Velayudhan,
Mrs. G. Durgabai,
Kala Venkatarao,
N. Gopalaswamy Ayyangar,
D. Govinda Das,
Revd. Jerome D'Souza,
P. Kakkan,
T.M. Kaliyannan Gounder,
K. Kamaraj,
V. C. Kesava Rao,
T. T. Krishnamachari,
Alladi Krishnaswamy Iyer
L. Krishnaswami Bharathi,
P. Kunhiraman,
Mosalikanti Thirumala Rao,
V. I. Munuswamy Pillai,
M. A. Muthiah Chettiar,
V. Nadimuthu Pillai,
S. Nagappa,
P. L. Narasimha Raju,
B. Pattabhi Sitaramayya,
C. Perumalswamy Reddy,
T. Prakasam,
S. H. Prater,
Raja Swetachalapati Ramakrishna Renga Roa of Bobbili,
R. K. Shanmukham Chetty,
T. A. Ramalingam Chettiar,
Ramnath Goenka,
O. P. Ramaswamy Reddiar,
N. G. Ranga,
Neelam Sanjeeva Reddy,
Sheik Galib Sahib,
K. Santhanam,
B. Shiva Rao,
Kallur Subba Rao,
U. Srinivasa Mallya,
P. Subbarayan,
C. Subramaniam,
V Subramaniam,
M. C. Veerabahu Pillai,
P. M. Velayudapani,
A. K. Menon,
T. J. M. Wilson,
Mohamed Ismail Sahib,
K. T. M. Ahmed Ibrahim,
Mahboob Ali Baig Sahib Bahadur,
B. Pocker Sahib Bahadur, pattam Tanupillai

text:
Bombay:
Balchandra Maheshwar Gupte,
Hansa Mehta,
Hari Vinayak Pataskar,
Dr. B. R. Ambedkar,
Joseph Alban D'Souza,
Kanayalal Nanabhai Desai,
Keshavrao Marutirao Jedhe,
Khandubhai Kasanji Desai,
Bal Gangadhar Kher,
M.R. Masani,
K.M. Munshi,
Narahar Vishnu Gadgil,
S. Nijalingappa,
S. K. Patil,
Ramchandra Manohar Nalavade,
R. R. Diwakar,
Shankarrao Deo,
G. V. Mavalankar,
Vallabhbhai Patel,
Abdul Kadar Mohammad Shaikh,
A. A. Khan

text:
West Bengal:
Monomohan Das,
Arun Chandra Guha,
Lakshmi Kanta Maitra,
Mihir Lal Chattopadhyay,
Satis Chandra Samanta,
Suresh Chandra Majumdar,
Upendranath Barman,
Prabhudayal Himatsingka,
Basanta Kumar Das,
Renuka Ray,
H. C. Mukherjee,
Surendra Mohan Ghose,
Syama Prasad Mookerjee,
Ari Bahadur Gurung,
R. E. Platel,
K. C. Neogy,
Raghib Ahsan,
Somnath Lahiri,
Jasimuddin Ahmad,
Naziruddin Ahmad,
Abdul Hamid,
Abdul Halim Ghuznavi

text:
United Provinces:
Ajit Prasad Jain,
Algu Rai Shastri,
Balkrishna Sharma,
Banshi Dhar Misra,
Bhagwan Din,
Damodar Swarup Seth,
Dayal Das Bhagat,
Dharam Prakash,
A. Dharam Dass,
R. V. Dhulekar,
Feroz Gandhi,
Gopal Narain,
Krishna Chandra Sharma,
Govind Ballabh Pant,
Govind Malviya,
Har Govind Pant,
Harihar Nath Shastri,
Hriday Nath Kunzru,
Jaspat Roy Kapoor,
Jagannath Baksh Singh,
Jawaharlal Nehru,
Jogendra Singh,
Jugal Kishore,
Jwala Prasad Srivastava,
B. V. Keskar,
Kamala Chaudhry,
Kamalapati Tripathi,
J. B. Kripalani,
Mahavir Tyagi,
Khurshed Lal,
Masurya Din,
Mohan Lal Saksena,
Padampat Singhania,
Phool Singh,
Paragi Lal,
Purnima Banerjee,
Purushottam Das Tandon,
Hira Vallabha Tripathi,
Ram Chandra Gupta,
Shibban Lal Saxena,
Satish Chandra,
John Matthai,
Sucheta Kripalani,
Sunder Lall,
Venkatesh Narayan Tiwari,
Mohanlal Gautam,
Vishwambhar Dayal Tripathi,
Vishnu Sharan Dublish,
Begum Aizaz Rasul,
Hyder Hussain,
Hasrat Mohani,
Abul Kalam Azad,
Muhammad Ismail Khan,
Rafi Ahmad Kidwai,
Mohd. Hifzur Rahman,
Z H Lari

text:
East Punjab:
Bakshi Tek Chand,
Jairamdas Daulatram,
Thakurdas Bhargava,
Bikramlal Sondhi,
Yashwant Rai,
Ranbir Singh Hooda,
Lala Achint Ram,
Nand Lal,
Baldev Singh,
Giani Gurmukh Singh Musafir,
Sardar Hukam Singh,
Sardar Bhopinder Singh Mann,
Sardar Rattan Singh Lohgarh
Chaudhry Suraj Mal

text:
Bihar:
Nasif Arafat,
Amiyo Kumar Ghosh,
Anugrah Narayan Sinha,
Banarsi Prasad Jhunjhunwala,
Bhagwat Prasad,
Boniface Lakra,
Brajeshwar Prasad,
Chandika Ram,
K. T. Shah,
Devendra Nath Samanta,
Dip Narain Sinha,
Guptanath Singh,
Jadubans Sahay,
Jagat Narain Lal,
Jagjivan Ram,
Jaipal Singh Munda,
Kameshwar Singh of Darbhanga,
Kamaleshwari Prasad Yadav,
Mahesh Prasad Sinha,
Krishna Ballabh Sahay,
Raghunandan Prasad,
Rajendra Prasad,
Rameshwar Prasad Sinha,
Ramnarayan Singh,
Sachchidananda Sinha,
Sarangdhar Sinha,
Satyanarayan Sinha,
Binodanand Jha,
P. K. Sen,
Sri Krishna Sinha,
Sri Narayan Mahtha,
Syamanandan Mishra,
Hussain Imam,
Syed Jafar Imam,
Latifur Rahman,
Mohammad Tahir,
Tajamul Hussain,
Choudhry Abid Hussain.
Hargovind Mishra

text:
Central Provinces and Berar:
Ambica Charan Shukla,
Raghu Vira,
Rajkumari Amrit Kaur,
B.A. Mandloi,
Brijlal Nandlal Biyani,
Thakur Cheedilal,
Seth Govind Das,
Hari Singh Gour,
Hari Vishnu Kamath,
Hemchandra Jagobaji Khandekar,
Ghanshyam Singh Gupta,
Lakshman Shrawan Bhatkar,
Panjabrao Shamrao Deshmukh,
Ravi Shankar Shukla,
R. K. Sidhva,
Shankar Trimbak Dharmadhikari,
Frank Anthony,
Kazi Syed Karimuddin,
Ganpatrao Dani

text:
Assam:
Nibaran Chandra Laskar,
Dharanidhar Basu-Matari,
Gopinath Bardoloi,
J. J. M. Nichols-Roy,
Kuladhar Chaliha,
Rohini Kumar Chaudhury,
Muhammad Saadulla,
Abdur Rouf

text:
Orissa:
Biswanath Das,
Krishna Chandra Gajapati Narayana Dev,
Harekrushna Mahatab,
Laxminarayan Sahu
Lokanath Mishra,
Nandkishore Das,
Rajkrishna Bose,
Santanu Kumar Das,
Yudhishir Mishra

text:
Delhi:
Deshbhandhu Gupta

text:
Ajmer-Merwara:
Mukut Bihari Lal Bhargava

text:
Coorg:
C. M. Poonacha

text:
Mysore:
K.C. Reddy,
T. Siddalingaiya,
H. R. Guruv Reddy,
S. V. Krishnamurthy Rao,
K. Hanumanthaiya,
H. Siddaveerappa,
T. Channiah

text:
Jammu and Kashmir:
Sheikh Muhammad Abdullah,
Motiram Baigra,
Mirza Mohammad Afzal Beg,
Maulana Mohammad Sayeed Masoodi

text:
Travancore-Cochin:
Pattom A. Thanu Pillai,
R. Sankar,
P. T. Chacko,
Panampilly Govinda Menon,
Annie Mascarene,
P.S.Nataraja Pillai,
K.A. Mohamed

text:
Madhya Bharat:
Vinayak Sitaram Sarwate,
Brijraj Narain,
Gopikrishna Vijayavargiya,
Ram Sahai,
Kusum Kant Jain,
Radhavallabh Vijayavargiya,
Sitaram S. Jajoo

text:
Saurashtra:
Balwant Rai Gopalji Mehta,
Jaisukhlal Hathi,
Amritlal Vithaldas Thakkar,
Chimanlal Chakubhai Shah,
Samaldas Laxmidas Gandhi

text:
Rajasthan:
V. T. Krishnamachari,
Hiralal Shastri,
Sardar Singhjhi of Khetri,
Jaswant Singhji,
Raj Bhadur,
Manikya Lal Varma,
Gokul Lal Asava,
Ramchandra Upadhyaya,
Balwant Sinha Mehta,
Dalel Singh,
Jainarain Vyas

text:
Patiala and East Punjab States Union:
Ranjit Singh,
Sochet Singh,
Bhagwant Roy

text:
Bombay States:
Vinayakrao Balshankar Vaidya,
B. N. Munavalli,
Gokulbhai Daulatram Bhatt,
Jivraj Narayan Mehta,
Gopaldas A. Desai,
Paranlal Thakurlal Munshi,
B. H. Khardekar,
Ratnappa Bharamappa Kumbhar

text:
Orissa States:
Lal Mohan Pati,
N. Madhava Rau,
Raj Kunwar,
Sarangadhar Das,
Yudhishthir Mishra

text:
Central Provinces States:
R. L. Malaviya,
Kishorimohan Tripathi,
Ramprasad Potai

text:
United Provinces States:
B. H. Zaidi,
Krishna Singh

text:
Madras States:
V. Ramaiah,
Ramakrishna Ranga Rao

text:
Vindhya Pradesh:
Avdesh Pratap Singh,
Shambu Nath Shukla,
Ram Sahai Tiwari,
Mannulalji Dwidedi

text:
Cooch Behar:
Himmat Singh K. Maheshwari

text:
Tripura and Manipur:
Girja Shankar Guha

text:
Bhopal:
Lal Singh

text:
Kutch:
Bhawani Arjun Khimji

text:
Himachal Pradesh:
Yashwant Singh Parmar

text: Members who later withdrew after partition[edit]

text:
East Bengal:
Abdullah al Mahmood,
Maulana Mohd Abdullah el Baqui,
Abdul Hamid,
Abdul Kasem Khan,
Mohammad Akram Khan,
A. Hamid,
Azizuddin Ahmad,
Muhammad Habibullah Bahar,
Prem Hari Barma,
Raj Kumar Chakraverty,
Sris Chandra Chattopadhyaya,
Abdul Matin Chaudhary,
Murtaza Raza Choudhry,
Hamidul Haq Chowdhury,
Akhay Kumar Das,
Dhirendra Nath Datta,
Bhupendra Kumar Datta,
Ebrahim Khan,
Fazlul Huq,
Fazlur Rahman,
Ghayasuddin Pathan,
Begum Shaista Suhrawardy Ikramullah,
Liaquat Ali Khan,
Mafizuddin Ahmad,
Mahmud Hussain,
Jnanendra Chandra Majumdar,
A. M. Malik,
Birat Chandra Mandal,
Jogendra Nath Mandal,
Mohammed Ali,
Khwaja Nazimuddin,
M.A.B.L. Nur Ahmed,
Nurul Amin,
Ishtiaq Hussain Qureshi,
Sri Dhananjoy M.A. B.L. Roy,
Maudi Bhakesh Chanda,
B.L. Serajul Islam,
Maulana Shabbir Ahmad Osmani,
Shahabudin Khwaja,
H.S. Suhrawardy,
Harendra Kumar Sur,
Tamizuddin Khan,
Kawivi Kerwar Datta,
Ghulam Mohammed

text:
West Punjab:
Mian Mumtaz Mohammad Khan Daultana,
Ganga Saran,
Zafarullah Khan,
Iftikhar Hussain Khan,
Mian Muhammad Iftikharuddin,
Muhammad Ali Jinnah,
Sheikh Karamat Ali,
Nazir Ahmad Khan,
Sardar Abdur Rab Nistar,
Feroz Khan Noon,
Omar Hayat Malik,
Shah Nawaz Begum Jahan Ara,
Sardar Shaukat Hyat Khan,

text:
Northwest Frontier Province:
Khan Abdul Ghafar Khan,
Khan Sardar Bahadur Khan,
Sardar Asad Ullah Jan Khan

text:
Sindh:
Abdus Sattar Abdur Rahman,
Alhajj Muhammad Hashim Gazder,
M.A. Khuhro

text:
Balochistan:
S. B. Nawab Mohammad Khan Jogezai

text: Gallery[edit]

text:
Jawaharlal Nehru and other members taking pledge during the midnight session of the Constituent Assembly of India held on 14 and 15 August 1947.

Dr. Babasaheb Ambedkar Chairman, Drafting Committee of the Indian Constitution with other members on Aug. 29, 1947.

Dr. Babasaheb Ambedkar, chairman of the Drafting Committee, presenting the final draft of the Indian Constitution to Dr. Rajendra Prasad on 25 November, 1949.

B. R. Ambedkar in Constituent Assembly of India.

Jawaharlal Nehru addressing the constituent assembly in 1946.


document_title: Metabolic pathway

question_text: what would be a typical regulatory system in a metabolic pathway

text: Metabolic pathway

text: Overview[edit]

text: Each metabolic pathway consists of a series of biochemical reactions that are connected by their intermediates: the products of one reaction are the substrates for subsequent reactions, and so on. Metabolic pathways are often considered to flow in one direction. Although all chemical reactions are technically reversible, conditions in the cell are often such that it is thermodynamically more favorable for flux to flow in one direction of a reaction. For example, one pathway may be responsible for the synthesis of a particular amino acid, but the breakdown of that amino acid may occur via a separate and distinct pathway. One example of an exception to this "rule" is the metabolism of glucose. Glycolysis results in the breakdown of glucose, but several reactions in the glycolysis pathway are reversible and participate in the re-synthesis of glucose (gluconeogenesis).

text: Glycolysis was the first metabolic pathway discovered:

text:
As glucose enters a cell, it is immediately phosphorylated by ATP to glucose 6-phosphate in the irreversible first step.
In times of excess lipid or protein energy sources, certain reactions in the glycolysis pathway may run in reverse to produce glucose 6-phosphate, which is then used for storage as glycogen or starch.

text:
Metabolic pathways are often regulated by feedback inhibition.
Some metabolic pathways flow in a 'cycle' wherein each component of the cycle is a substrate for the subsequent reaction in the cycle, such as in the Krebs Cycle (see below).
Anabolic and catabolic pathways in eukaryotes often occur independently of each other, separated either physically by compartmentalization within organelles or separated biochemically by the requirement of different enzymes and co-factors.

text: Major metabolic pathways[edit]

text:
Carbon
Fixation
Photo-
respiration
Pentose
Phosphate
Pathway
Citric
Acid Cycle
Glyoxylate
Cycle
Urea
Cycle
Fatty
Acid
Synthesis
Fatty
Acid
Elongation
Beta
Oxidation
Peroxisomal
Beta
Oxidation

Glyco-
genolysis
Glyco-
genesis
Glyco-
lysis
Gluconeo-
genesis
Decarb-
oxylation
Fermentation
Keto-
lysis
Keto-
genesis
feeders to
Gluconeo-
genesis
Direct / C4 / CAM
Carbon Intake
Light Reaction
Oxidative
Phosphorylation
Amino Acid
Deamination
Citrate
Shuttle
Lipogenesis
Lipolysis
Steroidogenesis
MVA Pathway
MEP Pathway
Shikimate
Pathway
Transcription &
Replication
Translation
Proteolysis
Glycosy-
lation

Sugar
Acids
Double/Multiple
Sugars & Glycans
Simple
Sugars
Inositol-P
Amino Sugars
& Sialic Acids
Nucleotide Sugars
Hexose-P
Triose-P
Glycerol
P-glycerates
Pentose-P
Tetrose-P
Propionyl
-CoA
Succinate
Acetyl
-CoA
Pentose-P
P-glycerates
Glyoxylate
Photosystems
Pyruvate
Lactate
Acetyl
-CoA
Citrate
Oxalo-
acetate
Malate
Succinyl
-CoA
α-Keto-
glutarate
Ketone
Bodies
Respiratory
Chain
Serine Group
Alanine
Branched-chain
Amino Acids
Aspartate
Group
Homoserine
Group
& Lysine
Glutamate
Group
& Proline
Arginine
Creatine
& Polyamines
Ketogenic &
Glucogenic
Amino Acids
Amino Acids
Shikimate
Aromatic Amino
Acids & Histidine
Ascorbate
(Vitamin C)
δ-ALA
Bile
Pigments
Hemes
Cobalamins (Vitamin B12)
Various
Vitamin B's
Calciferols
(Vitamin D)
Retinoids
(Vitamin A)
Quinones (Vitamin K)
& Carotenoids (Vitamin E)
Cofactors
Vitamins
& Minerals
Antioxidants
PRPP
Nucleotides
Nucleic
Acids
Proteins
Glycoproteins
& Proteoglycans
Chlorophylls
MEP
MVA
Acetyl
-CoA
Polyketides
Terpenoid
Backbones
Terpenoids
& Carotenoids (Vitamin A)
Cholesterol
Bile Acids
Glycero-
phospholipids
Glycerolipids
Acyl-CoA
Fatty
Acids
Glyco-
sphingolipids
Sphingolipids
Waxes
Polyunsaturated
Fatty Acids
Neurotransmitters
& Thyroid Hormones
Steroids
Endo-
cannabinoids
Eicosanoids

Major metabolic pathways in metro-style map. Click any text (name of pathway or metabolites) to link to the corresponding article.
Single lines: pathways common to most lifeforms. Double lines: pathways not in humans (occurs in e.g. plants, fungi, prokaryotes).  Orange nodes: carbohydrate metabolism.  Violet nodes: photosynthesis.  Red nodes: cellular respiration.  Pink nodes: cell signaling.  Blue nodes: amino acid metabolism.  Grey nodes: vitamin and cofactor metabolism.  Brown nodes: nucleotide and protein metabolism.  Green nodes: lipid metabolism.

text: Catabolic pathway (catabolism)[edit]

text: A catabolic pathway is a series of reactions that bring about a net release of energy in the form of a high energy phosphate bond formed with the energy carriers Adenosine Diphosphate (ADP) and Guanosine Diphosphate (GDP) to produce Adenosine Triphosphate (ATP) and Guanosine Triphosphate (GTP), respectively. The net reaction is, therefore, thermodynamically favorable, for it results in a lower free energy for the final products.[6] A catabolic pathway is an exergonic system that produces chemical energy in the form of ATP, GTP, NADH, NADPH, FADH2, etc. from energy containing sources such as carbohydrates, fats, and proteins. The end products are often carbon dioxide, water, and ammonia. Coupled with an endergonic reaction of anabolism, the cell can synthesize new macromolecules using the original precursors of the anabolic pathway.[7] An example of a coupled reaction is the phosphorylation of fructose-6-phosphate to form the intermediate fructose-1,6-bisphosphate by the enzyme phosphofructokinase accompanied by the hydrolysis of ATP in the pathway of glycolysis. The resulting chemical reaction within the metabolic pathway is highly thermodynamically favorable and, as a result, irreversible in the cell.[8]

text:
F
r
u
c
t
o
s
e
−
6
−
P
h
o
s
p
h
a
t
e
+
A
T
P
⟶
F
r
u
c
t
o
s
e
−
1
,
6
−
B
i
s
p
h
o
s
p
h
a
t
e
+
A
D
P

{\displaystyle Fructose-6-Phosphate+ATP\longrightarrow Fructose-1,6-Bisphosphate+ADP}

text: Cellular respiration[edit]

text: A core set of energy-producing catabolic pathways occur within all living organisms in some form. These pathways transfer the energy released by breakdown of nutrients into ATP and other small molecules used for energy (e.g. GTP, NADPH, FADH). All cells can perform anaerobic respiration by glycolysis. Additionally, most organisms can perform more efficient aerobic respiration through the citric acid cycle and oxidative phosphorylation. Additionally plants, algae and cyanobacteria are able to use sunlight to anabolically synthesize compounds from non-living matter by photosynthesis.

text: Anabolic pathway (anabolism)[edit]

text: In contrast to catabolic pathways, anabolic pathways require an energy input to construct macromolecules such as polypeptides, nucleic acids, proteins, polysaccharides, and lipids. The isolated reaction of anabolism is unfavorable in a cell due to a positive Gibbs Free Energy (+ΔG). Thus, an input of chemical energy through a coupling with an exergonic reaction is necessary.[9] The coupled reaction of the catabolic pathway affects the thermodynamics of the reaction by lowering the overall activation energy of an anabolic pathway and allowing the reaction to take place.[10] Otherwise, an endergonic reaction is non-spontaneous.

text: An anabolic pathway is a biosynthetic pathway, meaning that it combines smaller molecules to form larger and more complex ones.[11] An example is the reversed pathway of glycolysis, otherwise known as gluconeogenesis, which occurs in the liver and sometimes in the kidney to maintain proper glucose concentration in the blood and supply the brain and muscle tissues with adequate amount of glucose. Although gluconeogenesis is similar to the reverse pathway of glycolysis, it contains three distinct enzymes from glycolysis that allow the pathway to occur spontaneously.[12] An example of the pathway for gluconeogenesis is illustrated in the image titled "Gluconeogenesis Mechanism".

text: Amphibolic pathway[edit]

text: An amphibolic pathway is one that can be either catabolic or anabolic based on the availability of or the need for energy.[13] The currency of energy in a biological cell is adenosine triphosphate (ATP), which stores its energy in the phosphoanhydride bonds. The energy is utilized to conduct biosynthesis, facilitate movement, and regulate active transport inside of the cell.[14] Examples of amphibolic pathways are the citric acid cycle and the glyoxylate cycle. These sets of chemical reactions contain both energy producing and utilizing pathways.[15] To the right is an illustration of the amphibolic properties of the TCA cycle.

text: The glyoxylate shunt pathway is an alternative to the tricarboxylic acid (TCA) cycle, for it redirects the pathway of TCA to prevent full oxidation of carbon compounds, and to preserve high energy carbon sources as future energy sources. This pathway occurs only in plants and bacteria and transpires in the absence of glucose molecules.[16]

text: Regulation[edit]

text: The flux of the entire pathway is regulated by the rate-determining steps.[17] These are the slowest steps in a network of reactions. The rate-limiting step occurs near the beginning of the pathway and is regulated by feedback inhibition, which ultimately controls the overall rate of the pathway.[18] The metabolic pathway in the cell is regulated by covalent or non-covalent modifications. A covalent modification involves an addition or removal of a chemical bond, whereas a non-covalent modification (also known as allosteric regulation) is the binding of the regulator to the enzyme via hydrogen bonds, electrostatic interactions, and Van Der Waals forces.[19]

text: The rate of turnover in a metabolic pathway, otherwise known as the metabolic flux, is regulated based on the stoichiometric reaction model, the utilization rate of metabolites, and the translocation pace of molecules across the lipid bilayer.[20] The regulation methods are based on experiments involving 13C-labeling, which is then analyzed by Nuclear Magnetic Resonance (NMR) or gas chromatography-mass spectrometry (GC-MS)-derived mass compositions. The aforementioned techniques synthesize a statistical interpretation of mass distribution in proteinogenic amino acids to the catalytic activities of enzymes in a cell.[21]